Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors

por Schwestermann, Jonas, Besse, Andrej, Driessen, Christoph, Besse, Lenka
Publicado 2022

The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma

por Besse, Lenka, Kraus, Marianne, Besse, Andrej, Driessen, Christoph, Tarantino, Ignazio
Publicado 2023

The potential of CRISPR/Cas9 genome editing for the study and treatment of intervertebral disc pathologies

por Krupkova, Olga, Cambria, Elena, Besse, Lenka, Besse, Andrej, Bowles, Robert, Wuertz‐Kozak, Karin
Publicado 2018

Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells

por Byrgazov, Konstantin, Besse, Andrej, Kraus, Marianne, Slipicevic, Ana, Lehmann, Fredrik, Driessen, Christoph, Besse, Lenka
Publicado 2021

Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors

por Besse, Andrej, Kraus, Marianne, Mendez-Lopez, Max, Maurits, Elmer, Overkleeft, Herman S., Driessen, Christoph, Besse, Lenka
Publicado 2022

High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors

por Besse, Lenka, Besse, Andrej, Kraus, Marianne, Maurits, Elmer, Overkleeft, Herman S., Bornhauser, Beat, Bourquin, Jean-Pierre, Driessen, Christoph
Publicado 2021

MicroRNAs in urine are not biomarkers of multiple myeloma

por Sedlaříková, Lenka, Bešše, Lenka, Novosadová, Soňa, Kubaczková, Veronika, Radová, Lenka, Staník, Michal, Krejčí, Marta, Hájek, Roman, Ševčíková, Sabina
Publicado 2015

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

por Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado 2015

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

por Besse, Lenka, Sedlarikova, Lenka, Kryukov, Fedor, Nekvindova, Jana, Radova, Lenka, Slaby, Ondrej, Kuglik, Petr, Almasi, Martina, Penka, Miroslav, Krejci, Marta, Adam, Zdenek, Pour, Ludek, Sevcikova, Sabina, Hajek, Roman
Publicado 2015

Dynamics of tumor‐specific cfDNA in response to therapy in multiple myeloma patients

por Vrabel, David, Sedlarikova, Lenka, Besse, Lenka, Rihova, Lucie, Bezdekova, Renata, Almasi, Martina, Kubaczkova, Veronika, Brožová, Lucie, Jarkovsky, Jiri, Plonkova, Hana, Jelinek, Tomas, Sandecka, Viera, Stork, Martin, Pour, Ludek, Sevcikova, Sabina, Hajek, Roman
Publicado 2019

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

por Brenig, Robert, Pop, Oltin T, Triantafyllou, Evangelos, Geng, Anne, Singanayagam, Arjuna, Perez-Shibayama, Christian, Besse, Lenka, Cupovic, Jovana, Künzler, Patrizia, Boldanova, Tuyana, Brand, Stephan, Semela, David, Duong, François HT, Weston, Christopher J, Ludewig, Burkhard, Heim, Markus H, Wendon, Julia, Antoniades, Charalambos G, Bernsmeier, Christine
Publicado 2019

Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma

por Bolomsky, Arnold, Miettinen, Juho J., Malyutina, Alina, Besse, Andrej, Huber, Julia, Fellinger, Stefanie, Breid, Helene, Parsons, Alun, Klavins, Kristaps, Hannich, J. Thomas, Kubicek, Stefan, Caers, Jo, Hübl, Wolfgang, Schreder, Martin, Zojer, Niklas, Driessen, Christoph, Tang, Jing, Besse, Lenka, Heckman, Caroline A., Ludwig, Heinz
Publicado 2021

Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma

por Bandini, Cecilia, Mereu, Elisabetta, Paradzik, Tina, Labrador, Maria, Maccagno, Monica, Cumerlato, Michela, Oreglia, Federico, Prever, Lorenzo, Manicardi, Veronica, Taiana, Elisa, Ronchetti, Domenica, D’Agostino, Mattia, Gay, Francesca, Larocca, Alessandra, Besse, Lenka, Merlo, Giorgio Roberto, Hirsch, Emilio, Ciarrocchi, Alessia, Inghirami, Giorgio, Neri, Antonino, Piva, Roberto
Publicado 2023

High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-in...

por Zhou, Xiang, Besse, Andrej, Peter, Jessica, Steinhardt, Maximilian Johannes, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Xiao, Xianghui, Hornburger, Hannah, Haertle, Larissa, Mendez-Lopez, Max, Munawar, Umair, Riedel, Angela, Han, Seungbin, Maurits, Elmer, Overkleeft, Herman S., Florea, Bogdan, Einsele, Hermann, Kortüm, K. Martin, Driessen, Christoph, Besse, Lenka, Rasche, Leo
Publicado 2023

Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma

por Besse, Lenka, Besse, Andrej, Stolze, Sara C., Sobh, Amin, Zaal, Esther A., van der Ham, Alwin J., Ruiz, Mario, Phuyal, Santosh, Büchler, Lorina, Sathianathan, Marc, Florea, Bogdan I., Borén, Jan, Ståhlman, Marcus, Huber, Julia, Bolomsky, Arnold, Ludwig, Heinz, Hannich, J. Thomas, Loguinov, Alex, Everts, Bart, Berkers, Celia R., Pilon, Marc, Farhan, Hesso, Vulpe, Christopher D., Overkleeft, Herman S., Driessen, Christoph
Publicado 2021

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

por Ferguson, Ian D., Patiño-Escobar, Bonell, Tuomivaara, Sami T., Lin, Yu-Hsiu T., Nix, Matthew A., Leung, Kevin K., Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W., Wolf, Jeffrey L., Martin, Thomas G., Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Avery D., Mullins, R. Dyche, Eyquem, Justin, Wells, James A., Wiita, Arun P.
Publicado 2022