The genome-wide mutational consequences of DNA hypomethylation

por Besselink, Nicolle, Keijer, Janneke, Vermeulen, Carlo, Boymans, Sander, de Ridder, Jeroen, van Hoeck, Arne, Cuppen, Edwin, Kuijk, Ewart
Publicado 2023

Early divergence of mutational processes in human fetal tissues

por Kuijk, Ewart, Blokzijl, Francis, Jager, Myrthe, Besselink, Nicolle, Boymans, Sander, Chuva de Sousa Lopes, Susana M., van Boxtel, Ruben, Cuppen, Edwin
Publicado 2019

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

por Vlaar, Judith M., Borgman, Anouska, Kalkhoven, Eric, Westland, Denise, Besselink, Nicolle, Shale, Charles, Faltas, Bishoy M., Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin
Publicado 2022

Fibroblast growth factor receptor signaling in pediatric B-cell precursor acute lymphoblastic leukemia

por Jerchel, Isabel S., Hoogkamer, Alex Q., Ariës, Ingrid M., Boer, Judith M., Besselink, Nicolle J. M., Koudijs, Marco J., Pieters, Rob, den Boer, Monique L.
Publicado 2019

GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing

por Cameron, Daniel L., Baber, Jonathan, Shale, Charles, Valle-Inclan, Jose Espejo, Besselink, Nicolle, van Hoeck, Arne, Janssen, Roel, Cuppen, Edwin, Priestley, Peter, Papenfuss, Anthony T.
Publicado 2021

The mutational impact of culturing human pluripotent and adult stem cells

por Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Publicado 2020

Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells

por Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Publicado 2020

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

por Christensen, Sharon, Van der Roest, Bastiaan, Besselink, Nicolle, Janssen, Roel, Boymans, Sander, Martens, John W. M., Yaspo, Marie-Laure, Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin, Van Hoeck, Arne
Publicado 2019

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

por Jager, Myrthe, Blokzijl, Francis, Kuijk, Ewart, Bertl, Johanna, Vougioukalaki, Maria, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, de Ligt, Joep, Pedersen, Jakob Skou, Hoeijmakers, Jan, Pothof, Joris, van Boxtel, Ruben, Cuppen, Edwin
Publicado 2019

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

por Lips, Esther H., Michaut, Magali, Hoogstraat, Marlous, Mulder, Lennart, Besselink, Nicolle JM, Koudijs, Marco J., Cuppen, Edwin, Voest, Emile E., Bernards, Rene, Nederlof, Petra M., Wesseling, Jelle, Rodenhuis, Sjoerd, Wessels, Lodewyk FA
Publicado 2015

Prioritization of genes driving congenital phenotypes of patients with de novo genomic structural variants

por Middelkamp, Sjors, Vlaar, Judith M., Giltay, Jacques, Korzelius, Jerome, Besselink, Nicolle, Boymans, Sander, Janssen, Roel, de la Fonteijne, Lisanne, van Binsbergen, Ellen, van Roosmalen, Markus J., Hochstenbach, Ron, Giachino, Daniela, Talkowski, Michael E., Kloosterman, Wigard P., Cuppen, Edwin
Publicado 2019

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

por Beaufort, Corine M., Helmijr, Jean C. A., Piskorz, Anna M., Hoogstraat, Marlous, Ruigrok-Ritstier, Kirsten, Besselink, Nicolle, Murtaza, Muhammed, van IJcken, Wilfred F. J., Heine, Anouk A. J., Smid, Marcel, Koudijs, Marco J., Brenton, James D., Berns, Els M. J. J., Helleman, Jozien
Publicado 2014

JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia

por Steeghs, Elisabeth M.P., Jerchel, Isabel S., de Goffau-Nobel, Willemieke, Hoogkamer, Alex Q., Boer, Judith M., Boeree, Aurélie, van de Ven, Cesca, Koudijs, Marco J., Besselink, Nicolle J.M., de Groot-Kruseman, Hester A., Zwaan, Christian Michel, Horstmann, Martin A., Pieters, Rob, den Boer, Monique L.
Publicado 2017

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

por Nguyen, Luan, Jager, Myrthe, Lieshout, Ruby, de Ruiter, Petra E., Locati, Mauro D., Besselink, Nicolle, van der Roest, Bastiaan, Janssen, Roel, Boymans, Sander, de Jonge, Jeroen, IJzermans, Jan N. M., Doukas, Michail, Verstegen, Monique M. A., van Boxtel, Ruben, van der Laan, Luc J. W., Cuppen, Edwin, Kuijk, Ewart
Publicado 2021

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mT...

por Venkatesan, Subramanian, Hoogstraat, Marlous, Caljouw, Ester, Pierson, Tessa, Spoor, Jochem K.H., Zeneyedpour, Lona, Dubbink, Hendrikus J., Dekker, Lennard J., van der Kaaij, Mariëlle, Kloezeman, Jenneke, Berghauser Pont, Lotte M.E., Besselink, Nicolle J.M., Luider, Theo M., Joore, Jos, Martens, John W., Lamfers, Martine L.M., Sleijfer, Stefan, Leenstra, Sieger
Publicado 2016

A multi-platform reference for somatic structural variation detection

por Espejo Valle-Inclan, Jose, Besselink, Nicolle J.M., de Bruijn, Ewart, Cameron, Daniel L., Ebler, Jana, Kutzera, Joachim, van Lieshout, Stef, Marschall, Tobias, Nelen, Marcel, Priestley, Peter, Renkens, Ivo, Roemer, Margaretha G.M., van Roosmalen, Markus J., Wenger, Aaron M., Ylstra, Bauke, Fijneman, Remond J.A., Kloosterman, Wigard P., Cuppen, Edwin
Publicado 2022

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study

por Weeber, Fleur, Cirkel, Geert A., Hoogstraat, Marlous, Bins, Sander, Gadellaa-van Hooijdonk, Christa G.M., Ooft, Salo, van Werkhoven, Erik, Willems, Stefan M., van Stralen, Marijn, Veldhuis, Wouter B., Besselink, Nicolle J.M., Horlings, Hugo M., Steeghs, Neeltje, de Jonge, Maja J., Langenberg, Marlies H.G., Wessels, Lodewyk F.A., Cuppen, Edwin P.J.G., Schellens, J.H., Sleijfer, Stefan, Lolkema, Martijn P., Voest, Emile E.
Publicado 2017

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

por Bollen, Yannik, Stelloo, Ellen, van Leenen, Petra, van den Bos, Myrna, Ponsioen, Bas, Lu, Bingxin, van Roosmalen, Markus J., Bolhaqueiro, Ana C. F., Kimberley, Christopher, Mossner, Maximilian, Cross, William C. H., Besselink, Nicolle J. M., van der Roest, Bastiaan, Boymans, Sander, Oost, Koen C., de Vries, Sippe G., Rehmann, Holger, Cuppen, Edwin, Lens, Susanne M. A., Kops, Geert J. P. L., Kloosterman, Wigard P., Terstappen, Leon W. M. M., Barnes, Chris P., Sottoriva, Andrea, Graham, Trevor A., Snippert, Hugo J. G.
Publicado 2021