Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

por van Albada, Mirjam E., Mohnike, Klaus, Dunne, Mark J., Banerjee, Indi, Betz, Stephen F.
Publicado 2022

Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Is...

por Rico, Elizabeth, Zhao, Jian, Chen, Mi, Kusnetzow, Ana Karin, Zhu, Yun Fei, Betz, Stephen F
Publicado 2021

A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism

por Juliana, Christine A., Chai, Jinghua, Arroyo, Pablo, Rico-Bautista, Elizabeth, Betz, Stephen F., De León, Diva D.
Publicado 2023

Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

por Madan, Ajay, Markison, Stacy, Betz, Stephen F., Krasner, Alan, Luo, Rosa, Jochelson, Theresa, Lickliter, Jason, Struthers, R. Scott
Publicado 2022

SAT-429 Final Results from the First in Man Phase 1 Clinical Trial of CRN00808, an Orally Bioavailable sst2-Selective, Nonpeptide Somatostatin Biased Agonist, for the Treatment of...

por Madan, Ajay, Zhu, Yun Fei, Markison, Stacy, Betz, Stephen, Krasner, Alan, Luo, Rosa, Oltersdorf, Tilman, Jochelson, Theresa, Lickliter, Jason, Struthers, Scott
Publicado 2019

OR12-2 Inhibition of Basal and ACTH-stimulated Cortisol Secretion in Humans Using an Oral Nonpeptide ACTH Antagonist (CRN04894)

por Betz, Stephen, Ferrara-Cook, Christine, Hernandez-Illas, Martha, Luo, Rosa, Madan, Ajay, Miller, Stephanie, Struthers, Scott, Trainer, Peter, Wang, Yang, Krasner, Alan
Publicado 2022

PSUN304 CRN04777 an Oral, Nonpeptide SST5-selective Somatostatin Agonist Dose Dependently Suppresses Basal and Stimulated Insulin Secretion

por Ferrara-Cook, Christine, Luo, Rosa, De La Torre, Eduardo, Wang, Yang, Betz, Stephen, Madan, Ajay, Struthers, Scott, Hövelmann, Ulrike, Heise, Tim, Krasner, Alan
Publicado 2022

SAT-260 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Induced Insulin Secretion in Pancreatic Islets from both Rats and Healthy Human Donors

por Rico-Bautista, Elizabeth, Kusnetzow, Ana, Fowler, Melissa, Athanacio, Jon, Kredel, Taylor, Zhao, Jian, Wang, Shimiao, Markison, Stacy, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen
Publicado 2019

SAT-169 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Glucose- and Sulfonylurea-Induced Insulin Secretion in Rats

por Sturchler, Emmanuel, Fowler, Melissa, Athanacio, Jon, Kredel, Taylor, Johns, Michael, Zhao, Jian, Wang, Shimiao, Luo, Rosa, Kusnetzow, Ana, Zhu, Yun Fei, Madan, Ajay, Struthers, Scott, Betz, Stephen, Markison, Stacy
Publicado 2019

OR19-03 Effects of Nonpeptide Orally Bioavailable ACTH Antagonists on Adrenal Gland Size and Function in Rats

por Markison, Stacy, Fowler, Melissa A, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Cruz, Shirley, Luo, Rosa, Reinhart, Greg, Kusnetzow, Ana Karin, Madan, Ajay, Betz, Stephen F, Struthers, Scott
Publicado 2020

LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia

por Rico-Bautista, Elizabeth, Pontillo, Joseph, Wang, Shimiao, Antwan, Agnes S, Arroyo, Pablo, Fleck, Beth, Fowler, Melissa A, Reinhart, Greg, Johns, Michael A, Kusnetzow, Ana K, Zhu, Yun Fei, Markison, Stacy, Betz, Stephen F
Publicado 2022

FRI538 Discovery And Characterization Of Orally Bioavailable Nonpeptide Thyroid Stimulating Hormone Receptor (TSHR) Antagonists For The Treatment Of Graves’ Disease

por Fowler, Melissa A, Regan, Collin, Zhao, Jian, Coutinho, Eulalia, Fleck, Beth, Castellanos, Anel A, Muller, Eric, Johns, Michael, Tang, Yang, Sturchler, Emmanuel, Chen, Mi, Retting, Kelsey, Dalvie, Deepak, Betz, Stephen F, Markison, Stacy
Publicado 2023

Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

por Zhao, Jian, Wang, Shimiao, Markison, Stacy, Kim, Sun Hee, Han, Sangdon, Chen, Mi, Kusnetzow, Ana Karin, Rico-Bautista, Elizabeth, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Madan, Ajay, Zhu, Yunfei, Betz, Stephen F.
Publicado 2022

SAT182 Effects Of An Orally Bioavailable Nonpeptide Parathyroid Hormone Receptor Type 1 (PTH1R) Antagonist In Rodent Models Of Primary Hyperparathyroidism (PHPT)

por Antwan, Agnes S, Rico-Bautista, Elizabeth, Pontillo, Joe, Wang, Shimiao, Johns, Michael, Ramms, Bastian, Fowler, Melissa A, Nguyen, Julie B, Castellanos Gonzalez, Anel A, Fleck, Beth, Retting, Kelsey, Dalvie, Deepak, Betz, Stephen F, Markison, Stacy
Publicado 2023

Effects of CRN04894, a Nonpeptide Orally Bioavailable ACTH Antagonist, on Corticosterone in Rodent Models of ACTH Excess

por Fowler, Melissa A, Kusnetzow, Ana Karin, Han, Sangdon, Reinhart, Greg, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Athanacio, Jon, Tsivkovski, Oleg, Luo, Rosa, Madan, Ajay, Zhu, Yun Fei, Betz, Stephen F, Struthers, Scott, Markison, Stacy
Publicado 2021

SAT-364 Nonpeptide Orally-Bioavailable ACTH Antagonists: Suppression of ACTH-Induced Corticosterone Secretion and Adrenal Hypertrophy in Rats

por Kusnetzow, Ana, Fowler, Melissa, Athanacio, Jon, Reinhart, Greg, Rico-Bautista, Elizabeth, Han, Sangdon, Kim, Sun Hee, Johns, Michael, Kredel, Taylor, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen
Publicado 2019

MON-089 Discovery and Identification of Late Stage Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists for the Treatment of Hyperinsulinemic Hypoglycemia

por Fowler, Melissa A, Zhao, Jian, Sturchler, Emmanuel, Rico, Elizabeth, de Necochea-Campion, Rosalia, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Wang, Shmiao, Luo, Rosa, Kusnetzow, Ana Karin, Madan, Ajay, Struthers, Scott, Markison, Stacy, Zhu, Yun Fei, Betz, Stephen F
Publicado 2020

MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adren...

por Kusnetzow, Ana Karin, Han, Sangdon, Fowler, Melissa A, Athanacio, Jon, Reinhart, Greg, Rico, Elizabeth, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Tsivkovski, Oleg, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen F
Publicado 2020