The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment

por Parikh, Rahul A, Wang, Peng, Beumer, Jan H, Chu, Edward, Appleman, Leonard J
Publicado 2014

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma

por Beumer, Jan H., Fu, Katherine Y., Anyang, Bean N., Siegfried, Jill M., Bakkenist, Christopher J.
Publicado 2015

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

por Gamper, Armin M., Rofougaran, Reza, Watkins, Simon C., Greenberger, Joel S., Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2013

Radiation therapy induces the DNA damage response in peripheral blood

por Bakkenist, Christopher J., Czambel, R. Kenneth, Clump, David A., Greenberger, Joel S., Beumer, Jan H., Schmitz, John C.
Publicado 2013

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells

por Bakkenist, Christopher J., Czambel, R. Kenneth, Hershberger, Pamela A., Tawbi, Hussein, Beumer, Jan H., Schmitz, John C.
Publicado 2015

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy

por Mandell, Jonathan B., Lu, Feiqi, Fisch, Matthew, Beumer, Jan H., Guo, Jianxia, Watters, Rebecca J., Weiss, Kurt R.
Publicado 2019

Dose-Dependent Bioavailability and Tissue Distribution of the ATR Inhibitor AZD6738 (ceralasertib) in Mice

por Kiesel, Brian F., Guo, Jianxia, Parise, Robert. A, Venkataramanan, Raman, Clump, David A., Bakkenist, Christopher J., Beumer, Jan H.
Publicado 2022

ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

por Mandell, Jonathan B., Douglas, Nerone, Ukani, Vrutika, Beumer, Jan H., Guo, Jianxia, Payne, John, Newman, Rebecca, Mancinelli, Luigi, Intini, Giuseppe, Anderson, Carolyn J., Watters, Rebecca, Weiss, Kurt
Publicado 2022

The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy

por Vendetti, Frank P., Pandya, Pinakin, Clump, David A., Schamus-Haynes, Sandra, Tavakoli, Meysam, diMayorca, Maria, Islam, Naveed M., Chang, Jina, Delgoffe, Greg M., Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2023

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

por Vendetti, Frank P., Leibowitz, Brian J., Barnes, Jennifer, Schamus, Sandy, Kiesel, Brian F., Abberbock, Shira, Conrads, Thomas, Clump, David Andy, Cadogan, Elaine, O’Connor, Mark J., Yu, Jian, Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2017

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

por Lee, Dae-Hee, Zhang, Ying, Kassam, Amin B., Park, Myung-Jin, Gardner, Paul, Prevedello, Daniel, Henry, Stephanie, Horbinski, Craig, Beumer, Jan H., Tawbi, Hussein, Williams, Brian J., Shaffrey, Mark E., Egorin, Merrill J., Abounader, Roger, Park, Deric M.
Publicado 2015

Blocking the ZZ Domain of Sequestosome1/p62 Suppresses Myeloma Growth and Osteoclast Formation In Vitro and Induces Dramatic Bone Formation in Myeloma-Bearing Bones In Vivo

por Teramachi, Jumpei, Silbermann, Rebecca, Yang, Peng, Zhao, Wei, Mohammad, Khalid S., Guo, Jianxia, Anderson, Judith L., Zhou, Dan, Feng, Rentian, Myint, Kyaw-Zeyar, Maertz, Nathan, Beumer, Jan H., Eiseman, Julie L., Windle, Jolene J., Xie, Xiang-Qun, Roodman, G. David, Kurihara, Noriyoshi
Publicado 2015

Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL

por Wieduwilt, Matthew J., Yin, Jun, Wetzler, Meir, Uy, Geoffrey L., Powell, Bayard L., Kolitz, Jonathan E., Liedtke, Michaela, Stock, Wendy, Beumer, Jan H., Mattison, Ryan J., Storrick, Elizabeth, Christner, Susan M., Lewis, Lionel D., Devine, Steven, Stone, Richard M., Larson, Richard A.
Publicado 2021

Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer

por Owonikoko, Taofeek K, Zhang, Guojing, Deng, Xingming, Rossi, Michael R, Switchenko, Jeffrey M, Doho, Gregory H, Chen, Zhengjia, Kim, Sungjin, Strychor, Sandy, Christner, Susan M, Beumer, Jan, Li, Chunyang, Yue, Ping, Chen, Alice, Sica, Gabriel L, Ramalingam, Suresh S, Kowalski, Jeanne, Khuri, Fadlo R, Sun, Shi-Yong
Publicado 2014

Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

por Sugitani, Norie, Vendetti, Frank P., Cipriano, Andrew J., Pandya, Pinakin, Deppas, Joshua J., Moiseeva, Tatiana N., Schamus-Haynes, Sandra, Wang, Yiyang, Palmer, Drake, Osmanbeyoglu, Hatice U., Bostwick, Anna, Snyder, Nathaniel W., Gong, Yi-Nan, Aird, Katherine M., Delgoffe, Greg M., Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2022

Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10

por Abraham, Jame, Montero, Albert J., Jankowitz, Rachel C., Salkeni, Mohamad Adham, Beumer, Jan H., Kiesel, Brian F., Piette, Fanny, Adamson, Laura M., Nagy, Rebecca J., Lanman, Richard B., Sperinde, Jeff, Huang, Weidong, Allegra, Carmen J., Srinivasan, Ashok, Wang, Ying, Pogue-Geile, Katherine L., Lucas, Peter C., Jacobs, Samuel A.
Publicado 2019

A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction

por Takebe, Naoko, Beumer, Jan H., Kummar, Shivaani, Kiesel, Brian F., Dowlati, Afshin, O'Sullivan Coyne, Geraldine, Piekarz, Richard, Rubinstein, Lawrence, Fogli, Laura K., Vaishampayan, Ulka, Goel, Sanjay, O'Bryant, Cindy L., El‐Rayes, Bassel F., Chung, Vincent, Lenz, Heinz‐Josef, Kim, Richard, Belani, Chandra P., Tuscano, Joseph M., Schelman, William, Moore, Nancy, Doroshow, James H., Chen, Alice P.
Publicado 2019

Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors...

por Coyne, Geraldine O.’Sullivan, Wang, Lihua, Zlott, Jennifer, Juwara, Lamin, Covey, Joseph M., Beumer, Jan H., Cristea, Mihaela C., Newman, Edward M., Koehler, Stephen, Nieva, Jorge J., Garcia, Agustin A., Gandara, David R., Miller, Brandon, Khin, Sonny, Miller, Sarah B., Steinberg, Seth M., Rubinstein, Larry, Parchment, Ralph E., Kinders, Robert J., Piekarz, Richard L., Kummar, Shivaani, Chen, Alice P., Doroshow, James H.
Publicado 2020

Tumor cell p38 inhibition to overcome immunotherapy resistance

por Luke, Jason J., Dadey, Rebekah E., Augustin, Ryan C., Newman, Sarah, Singh, Krishna B., Doerfler, Rose, Behr, Sarah, Lee, Patrice, Isett, Brian, Deitrick, Christopher, Li, Aofei, Joy, Marion, Reeder, Carly, Smith, Katelyn, Urban, Julie, Sellitto, Lorenzo, Jelinek, Mark, Christner, Susan M., Beumer, Jan H., Villaruz, Liza C., Kulkarni, Aditi, Davar, Diwakar, Poklepovic, Andrew S., Najjar, Yana, Zandberg, Dan P., Soloff, Adam C., Bruno, Tullia C., Vujanović, Lazar, Skinner, Heath D., Ferris, Robert L., Bao, Riyue
Publicado 2023