Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae

por Aguinagalde Salazar, Leire, den Boer, Maurits A, Castenmiller, Suzanne M, Zwarthoff, Seline A, de Haas, Carla, Aerts, Piet C, Beurskens, Frank J, Schuurman, Janine, Heck, Albert JR, van Kessel, Kok, Rooijakkers, Suzan HM
Publicado 2023

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

por Parzych, Elizabeth M., Gulati, Sunita, Zheng, Bo, Bah, Mamadou A., Elliott, Sarah T. C., Chu, Jacqueline D., Nowak, Nancy, Reed, George W., Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Weiner, David B., Ram, Sanjay
Publicado 2021

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

por van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patrick HC, Parren, Paul WHI
Publicado 2015

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

por de Jong, Rob N., Beurskens, Frank J., Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D., Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J., Oostindie, Simone C., Wang, Guanbo, Heck, Albert J. R., Schuurman, Janine, Parren, Paul W. H. I.
Publicado 2016

Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma

por de Vor, Lisanne, Beudeker, Coco R., Flier, Anne, Scheepmaker, Lisette M., Aerts, Piet C., Vijlbrief, Daniel C., Bekker, Mireille N., Beurskens, Frank J., van Kessel, Kok P. M., de Haas, Carla J. C., Rooijakkers, Suzan H. M., van der Flier, Michiel
Publicado 2022

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

por Gulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls, Robin R., Woodruff, Trent M., Song, Wen-Chao, Schuurman, Janine, Rice, Peter A., Ram, Sanjay
Publicado 2019

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

por Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.
Publicado 2017

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

por Cruz, Ana Rita, den Boer, Maurits A., Strasser, Jürgen, Zwarthoff, Seline A., Beurskens, Frank J., de Haas, Carla J. C., Aerts, Piet C., Wang, Guanbo, de Jong, Rob N., Bagnoli, Fabio, van Strijp, Jos A. G., van Kessel, Kok P. M., Schuurman, Janine, Preiner, Johannes, Heck, Albert J. R., Rooijakkers, Suzan H. M.
Publicado 2021

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

por Oostindie, Simone C., van der Horst, Hilma J., Lindorfer, Margaret A., Cook, Erika M., Tupitza, Jillian C., Zent, Clive S., Burack, Richard, VanDerMeid, Karl R., Strumane, Kristin, Chamuleau, Martine E. D., Mutis, Tuna, de Jong, Rob N., Schuurman, Janine, Breij, Esther C. W., Beurskens, Frank J., Parren, Paul W. H. I., Taylor, Ronald P.
Publicado 2019

C1q binding to surface-bound IgG is stabilized by C1r(2)s(2) proteases

por Zwarthoff, Seline A., Widmer, Kevin, Kuipers, Annemarie, Strasser, Jürgen, Ruyken, Maartje, Aerts, Piet C., de Haas, Carla J. C., Ugurlar, Deniz, den Boer, Maurits A., Vidarsson, Gestur, van Strijp, Jos A. G., Gros, Piet, Parren, Paul W. H. I., van Kessel, Kok P. M., Preiner, Johannes, Beurskens, Frank J., Schuurman, Janine, Ricklin, Daniel, Rooijakkers, Suzan H. M.
Publicado 2021

Logic-gated antibody pairs that selectively act on cells co-expressing two antigens

por Oostindie, Simone C., Rinaldi, Derek A., Zom, Gijs G., Wester, Michael J., Paulet, Desiree, Al-Tamimi, Kusai, van der Meijden, Els, Scheick, Jennifer R., Wilpshaar, Tessa, de Jong, Bart, Hoff-van den Broek, Marloes, Grattan, Rachel M., Oosterhoff, Janita J., Vignau, Julie, Verploegen, Sandra, Boross, Peter, Beurskens, Frank J., Lidke, Diane S., Schuurman, Janine, de Jong, Rob N.
Publicado 2022

DuoHexaBody-CD37(®), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

por Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.
Publicado 2020