Finafloxacin, a Novel Fluoroquinolone, Reduces the Clinical Signs of Infection and Pathology in a Mouse Model of Q Fever

por Hartley, M. Gill, Norville, Isobel H., Richards, Mark I., Barnes, Kay B., Bewley, Kevin R., Vipond, Julia, Rayner, Emma, Vente, Andreas, Armstrong, Stuart J., Harding, Sarah V.
Publicado 2021

Assessment of the Biological Impact of SARS-CoV-2 Genetic Variation Using an Authentic Virus Neutralisation Assay with Convalescent Plasma, Vaccinee Sera, and Standard Reagents

por Coombes, Naomi S., Bewley, Kevin R., Le Duff, Yann, Hurley, Matthew, Smith, Lauren J., Weldon, Thomas M., Osman, Karen, Pullan, Steven, Berry, Neil, Hallis, Bassam, Charlton, Sue, Hall, Yper, Funnell, Simon G. P.
Publicado 2023

Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens

por Lean, Fabian Z. X., Lamers, Mart M., Smith, Samuel P., Shipley, Rebecca, Schipper, Debby, Temperton, Nigel, Haagmans, Bart L., Banyard, Ashley C., Bewley, Kevin R., Carroll, Miles W., Brookes, Sharon M., Brown, Ian, Nuñez, Alejandro
Publicado 2020

The Omicron Sub-Variant BA.4 Displays a Remarkable Lack of Clinical Signs in a Golden Syrian Hamster Model of SARS-CoV-2 Infection

por Davies, Elizabeth R., Ryan, Kathryn A., Bewley, Kevin R., Coombes, Naomi S., Salguero, Francisco J., Carnell, Oliver T., Biddlecombe, Sarah, Charlton, Michael, Challis, Amy, Cross, Eleanor S., Handley, Alastair, Ngabo, Didier, Weldon, Thomas M., Hall, Yper, Funnell, Simon G. P.
Publicado 2023

SARS-CoV-2 Disease Severity in the Golden Syrian Hamster Model of Infection Is Related to the Volume of Intranasal Inoculum

por Handley, Alastair, Ryan, Kathryn A., Davies, Elizabeth R., Bewley, Kevin R., Carnell, Oliver T., Challis, Amy, Coombes, Naomi S., Fotheringham, Susan A., Gooch, Karen E., Charlton, Michael, Harris, Debbie J., Kennard, Chelsea, Ngabo, Didier, Weldon, Thomas M., Salguero, Francisco J., Funnell, Simon G. P., Hall, Yper
Publicado 2023

A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

por Funnell, Simon G. P., Afrough, Babak, Baczenas, John James, Berry, Neil, Bewley, Kevin R., Bradford, Rebecca, Florence, Clint, Duff, Yann Le, Lewis, Mark, Moriarty, Ryan V., Connor, Shelby L. O., Osman, Karen L., Pullan, Steven, Rashid, Sujatha, Richards, Kevin S., Stemple, Kimberly J., Knezevic, Ivana
Publicado 2021

mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant

por Parry, Helen, Tut, Gokhan, Bruton, Rachel, Faustini, Sian, Stephens, Christine, Saunders, Philip, Bentley, Christopher, Hilyard, Katherine, Brown, Kevin, Amirthalingam, Gayatri, Charlton, Sue, Leung, Stephanie, Chiplin, Emily, Coombes, Naomi S, Bewley, Kevin R, Penn, Elizabeth J, Rowe, Cathy, Otter, Ashley, Watts, Rosie, D'Arcangelo, Silvia, Hallis, Bassam, Makin, Andrew, Richter, Alex, Zuo, Jianmin, Moss, Paul
Publicado 2021

Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection

por Everett, Helen E., Lean, Fabian Z. X., Byrne, Alexander M. P., van Diemen, Pauline M., Rhodes, Shelley, James, Joe, Mollett, Benjamin, Coward, Vivien J., Skinner, Paul, Warren, Caroline J., Bewley, Kevin R., Watson, Samantha, Hurley, Shellene, Ryan, Kathryn A., Hall, Yper, Simmons, Hugh, Núñez, Alejandro, Carroll, Miles W., Brown, Ian H., Brookes, Sharon M.
Publicado 2021

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

por Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Publicado 2020

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

por Proud, Pamela C., Tsitoura, Daphne, Watson, Robert J., Chua, Brendon Y., Aram, Marilyn J., Bewley, Kevin R., Cavell, Breeze E., Cobb, Rebecca, Dowall, Stuart, Fotheringham, Susan A., Ho, Catherine M.K., Lucas, Vanessa, Ngabo, Didier, Rayner, Emma, Ryan, Kathryn A., Slack, Gillian S., Thomas, Stephen, Wand, Nadina I., Yeates, Paul, Demaison, Christophe, Zeng, Weiguang, Holmes, Ian, Jackson, David C., Bartlett, Nathan W., Mercuri, Francesca, Carroll, Miles W.
Publicado 2020

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques

por Bewley, Kevin R., Gooch, Karen, Thomas, Kelly M., Longet, Stephanie, Wiblin, Nathan, Hunter, Laura, Chan, Kin, Brown, Phillip, Russell, Rebecca A., Ho, Catherine, Slack, Gillian, Humphries, Holly E., Alden, Leonie, Allen, Lauren, Aram, Marilyn, Baker, Natalie, Brunt, Emily, Cobb, Rebecca, Fotheringham, Susan, Harris, Debbie, Kennard, Chelsea, Leung, Stephanie, Ryan, Kathryn, Tolley, Howard, Wand, Nadina, White, Andrew, Sibley, Laura, Sarfas, Charlotte, Pearson, Geoff, Rayner, Emma, Xue, Xiaochao, Lambe, Teresa, Charlton, Sue, Gilbert, Sarah, Sattentau, Quentin J., Gleeson, Fergus, Hall, Yper, Funnell, Simon, Sharpe, Sally, Salguero, Francisco J., Gorringe, Andrew, Carroll, Miles
Publicado 2021

Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant

por Ryan, Kathryn A., Bewley, Kevin R., Watson, Robert J., Burton, Christopher, Carnell, Oliver, Cavell, Breeze E., Challis, Amy, Coombes, Naomi S., Davies, Elizabeth R., Edun-Huges, Jack, Emery, Kirsty, Fell, Rachel, Fotheringham, Susan A., Gooch, Karen E., Gowan, Kathryn, Handley, Alastair, Harris, Debbie J., Hesp, Richard, Hunter, Laura, Humphreys, Richard, Johnson, Rachel, Kennard, Chelsea, Knott, Daniel, Lister, Sian, Morley, Daniel, Ngabo, Didier, Osman, Karen L., Paterson, Jemma, Penn, Elizabeth J., Pullan, Steven T., Richards, Kevin S., Summers, Sian, Thomas, Stephen R., Weldon, Thomas, Wiblin, Nathan R., Rayner, Emma L., Vipond, Richard T., Hallis, Bassam, Salguero, Francisco J., Funnell, Simon G. P., Hall, Yper
Publicado 2023

ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

por Lambe, Teresa, Spencer, Alexandra J., Thomas, Kelly M., Gooch, Karen E., Thomas, Stephen, White, Andrew D., Humphries, Holly E., Wright, Daniel, Belij-Rammerstorfer, Sandra, Thakur, Nazia, Conceicao, Carina, Watson, Robert, Alden, Leonie, Allen, Lauren, Aram, Marilyn, Bewley, Kevin R., Brunt, Emily, Brown, Phillip, Cavell, Breeze E., Cobb, Rebecca, Fotheringham, Susan A., Gilbride, Ciaran, Harris, Debbie J., Ho, Catherine M. K., Hunter, Laura, Kennard, Chelsea L., Leung, Stephanie, Lucas, Vanessa, Ngabo, Didier, Ryan, Kathryn A., Sharpe, Hannah, Sarfas, Charlotte, Sibley, Laura, Slack, Gillian S., Ulaszewska, Marta, Wand, Nadina, Wiblin, Nathan R., Gleeson, Fergus V., Bailey, Dalan, Sharpe, Sally, Charlton, Sue, Salguero, Francisco J., Carroll, Miles W., Gilbert, Sarah C.
Publicado 2021

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

por Supasa, Piyada, Zhou, Daming, Dejnirattisai, Wanwisa, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin R., Charlton, Sue, Walter, Thomas S., Barnes, Eleanor, Dunachie, Susanna J., Skelly, Donal, Lumley, Sheila F., Baker, Natalie, Shaik, Imam, Humphries, Holly E., Godwin, Kerry, Gent, Nick, Sienkiewicz, Alex, Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, Hall, David R., Williams, Mark A., Paterson, Neil G., James, William, Carroll, Miles W., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2021

Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

por Ryan, Kathryn A., Bewley, Kevin R., Fotheringham, Susan A., Slack, Gillian S., Brown, Phillip, Hall, Yper, Wand, Nadina I., Marriott, Anthony C., Cavell, Breeze E., Tree, Julia A., Allen, Lauren, Aram, Marilyn J., Bean, Thomas J., Brunt, Emily, Buttigieg, Karen R., Carter, Daniel P., Cobb, Rebecca, Coombes, Naomi S., Findlay-Wilson, Steve J., Godwin, Kerry J., Gooch, Karen E., Gouriet, Jade, Halkerston, Rachel, Harris, Debbie J., Hender, Thomas H., Humphries, Holly E., Hunter, Laura, Ho, Catherine M. K., Kennard, Chelsea L., Leung, Stephanie, Longet, Stephanie, Ngabo, Didier, Osman, Karen L., Paterson, Jemma, Penn, Elizabeth J., Pullan, Steven T., Rayner, Emma, Skinner, Oliver, Steeds, Kimberley, Taylor, Irene, Tipton, Tom, Thomas, Stephen, Turner, Carrie, Watson, Robert J., Wiblin, Nathan R., Charlton, Sue, Hallis, Bassam, Hiscox, Julian A., Funnell, Simon, Dennis, Mike J., Whittaker, Catherine J., Catton, Michael G., Druce, Julian, Salguero, Francisco J., Carroll, Miles W.
Publicado 2021

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

por Salguero, Francisco J., White, Andrew D., Slack, Gillian S., Fotheringham, Susan A., Bewley, Kevin R., Gooch, Karen E., Longet, Stephanie, Humphries, Holly E., Watson, Robert J., Hunter, Laura, Ryan, Kathryn A., Hall, Yper, Sibley, Laura, Sarfas, Charlotte, Allen, Lauren, Aram, Marilyn, Brunt, Emily, Brown, Phillip, Buttigieg, Karen R., Cavell, Breeze E., Cobb, Rebecca, Coombes, Naomi S., Darby, Alistair, Daykin-Pont, Owen, Elmore, Michael J., Garcia-Dorival, Isabel, Gkolfinos, Konstantinos, Godwin, Kerry J., Gouriet, Jade, Halkerston, Rachel, Harris, Debbie J., Hender, Thomas, Ho, Catherine M. K., Kennard, Chelsea L., Knott, Daniel, Leung, Stephanie, Lucas, Vanessa, Mabbutt, Adam, Morrison, Alexandra L., Nelson, Charlotte, Ngabo, Didier, Paterson, Jemma, Penn, Elizabeth J., Pullan, Steve, Taylor, Irene, Tipton, Tom, Thomas, Stephen, Tree, Julia A., Turner, Carrie, Vamos, Edith, Wand, Nadina, Wiblin, Nathan R., Charlton, Sue, Dong, Xiaofeng, Hallis, Bassam, Pearson, Geoffrey, Rayner, Emma L., Nicholson, Andrew G., Funnell, Simon G., Hiscox, Julian A., Dennis, Mike J., Gleeson, Fergus V., Sharpe, Sally, Carroll, Miles W.
Publicado 2021