Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib

por Tkacik, Emre, Li, Kunhua, Gonzalez-Del Pino, Gonzalo, Ha, Byung Hak, Vinals, Javier, Park, Eunyoung, Beyett, Tyler S., Eck, Michael J.
Publicado 2023

Biochemical characterization of the interaction between KRAS and Argonaute 2

por Waninger, Jessica J., Beyett, Tyler S., Gadkari, Varun V., Siebenaler, Ronald F., Kenum, Carson, Shankar, Sunita, Ruotolo, Brandon T., Chinnaiyan, Arul M., Tesmer, John J.G.
Publicado 2021

Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

por Nakamura, Ikuko Takeda, Kohsaka, Shinji, Ikegami, Masachika, Ikeuchi, Hiroshi, Ueno, Toshihide, Li, Kunhua, Beyett, Tyler S., Koyama, Takafumi, Shimizu, Toshio, Yamamoto, Noboru, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Eck, Michael J., Mano, Hiroyuki
Publicado 2021

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

por Beyett, Tyler S., To, Ciric, Heppner, David E., Rana, Jaimin K., Schmoker, Anna M., Jang, Jaebong, De Clercq, Dries J. H., Gomez, Gabriel, Scott, David A., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J.
Publicado 2022

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

por Heppner, David, Wittlinger, Florian, Ogboo, Blessing, Shevchenko, Ekaterina, Damghani, Tahereh, Pham, Calvin, Schaeffner, Ilse, Oligny, Brandon, Chitnis, Surbhi, Beyett, Tyler, Rasch, Alexander, Buckley, Brian, Urul, Daniel, Shaurova, Tatiana, May, Earl, Schaefer, Erik, Eck, Michael, Hershberger, Pamela, Poso, Antti, Laufer, Stefan
Publicado 2023