PB1788: A SCREENING OF DONATED CHEMICAL PROBES TO IDENTIFY NOVEL THERAPEUTIC OPTIONS FOR ACUTE MYELOID LEUKEMIA (AML) IN CHILDHOOD

por Laszig, Stephanie, Bhayadia, Raj, Klusmann, Jan-Henning, Knapp, Stefan
Publicado 2023

P419: HARNESSING MIRNA-193B-3P MIMIC AS A POTENT THERAPEUTIC OPTION IN ACUTE MYELOID LEUKEMIA

por Issa, Hasan, Bhayadia, Raj, Winkler, Robert, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

por Grimm, Juliane, Bhayadia, Raj, Gack, Lucie, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2022

Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias

por Issa, Hasan, Bhayadia, Raj, Winkler, Robert, Swart, Laura Elise, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

P467: LONG NON-CODING RNA SNHG29 IS A NOVEL MYELOID LEUKEMIA DEPENDENCY

por Winkler, Robert, Heckl, Dirk, Ng, Michelle, Boon, Reinier, Issa, Hasan, Bhayadia, Raj, Klusmann, Jan-Henning
Publicado 2023

PB1825: IDENTIFYING GENE TARGETS FOR DRUG REPURPOSING TO COUNTER MYELOID LEUKEMIA IN CHILDREN WITH DOWN-SYNDROME (ML-DS)

por Schmell, Anna-Lena, Meier, Kristof, Alejo-Valle, Oriol, Heckel, Dirk, Bhayadia, Raj, Klusmann, Jan-Henning
Publicado 2023

P1354: CRISPR/CAS9 GENE EDITING OF IMMUNE CHECKPOINT RECEPTOR NKG2A IMPROVES THE ANTI-LEUKEMIC EFFICACY OF PRIMARY CD33-TARGETING CAR-NK CELLS.

por Albinger, Nawid, Bexte, Tobias, Al-Ajami, Ahmad, Wendel, Philipp, Buchinger, Leon, Gessner, Alec, Alzubi, Jamal, Särchen, Vinzenz, Vogler, Meike, Bhayadia, Raj, Klusmann, Jan-Henning, Möker, Nina, Cathomen, Toni, Rieger, Michael A., Imkeller, Katharina, Ullrich, Evelyn
Publicado 2023

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15

por Ng, Michelle, Verboon, Lonneke, Issa, Hasan, Bhayadia, Raj, Vermunt, Marit Willemijn, Winkler, Robert, Schüler, Leah, Alejo, Oriol, Schuschel, Konstantin, Regenyi, Eniko, Borchert, Dorit, Heuser, Michael, Reinhardt, Dirk, Yaspo, Marie-Laure, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

por Alejo-Valle, Oriol, Weigert, Karoline, Bhayadia, Raj, Ng, Michelle, Issa, Hasan, Beyer, Christoph, Emmrich, Stephan, Schuschel, Konstantin, Ihling, Christian, Sinz, Andrea, Zimmermann, Martin, Wickenhauser, Claudia, Flasinski, Marius, Regenyi, Eniko, Labuhn, Maurice, Reinhardt, Dirk, Yaspo, Marie-Laure, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2022

PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia

por Alshamleh, Islam, Kurrle, Nina, Makowka, Philipp, Bhayadia, Raj, Kumar, Rahul, Süsser, Sebastian, Seibert, Marcel, Ludig, Damian, Wolf, Sebastian, Koschade, Sebastian E., Stoschek, Karoline, Kreitz, Johanna, Fuhrmann, Dominik C., Toenges, Rosa, Notaro, Marco, Comoglio, Federico, Schuringa, Jan Jacob, Berg, Tobias, Brüne, Bernhard, Krause, Daniela S., Klusmann, Jan-Henning, Oellerich, Thomas, Schnütgen, Frank, Schwalbe, Harald, Serve, Hubert
Publicado 2023

RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

por Gialesaki, Sofia, Bräuer-Hartmann, Daniela, Issa, Hasan, Bhayadia, Raj, Alejo-Valle, Oriol, Verboon, Lonneke, Schmell, Anna-Lena, Laszig, Stephanie, Regényi, Enikő, Schuschel, Konstantin, Labuhn, Maurice, Ng, Michelle, Winkler, Robert, Ihling, Christian, Sinz, Andrea, Glaß, Markus, Hüttelmaier, Stefan, Matzk, Sören, Schmid, Lena, Strüwe, Farina Josepha, Kadel, Sofie-Katrin, Reinhardt, Dirk, Yaspo, Marie-Laure, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

P422: TARGETING THE WT1MUT-MIR-193A TRANSCRIPTIONAL AXIS WITH INT-1B3, A NOVEL LIPID NANOPARTICLE-FORMULATED MIR-193A-3P MIMIC IN ACUTE MYELOID LEUKEMIA

por Yang, Xining, Krowiorz, Kathrin, Buelow, Daelynn, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wei Wu, Si, van den Bosch, Marion, Escano, Leo, Lock, Frances, Panahi, Afsaneh, Macphee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann-Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Klusmann, Jan-Henning, Baker, Sharyn, Oakes, Christopher, Rouhi, Arefeh, Kuchenbauer, Florian
Publicado 2023