Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide

por Gambin, Yann, Polinkovsky, Mark, Francois, Bill, Giles, Nichole, Bhumkar, Akshay, Sierecki, Emma
Publicado 2016

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein

por Leitao, Andre, Bhumkar, Akshay, Hunter, Dominic J. B., Gambin, Yann, Sierecki, Emma
Publicado 2018

Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients

por Bhumkar, Akshay, Magnan, Chloe, Lau, Derrick, Jun, Eugene Soh Wei, Dzamko, Nicolas, Gambin, Yann, Sierecki, Emma
Publicado 2021

A Split-Luciferase Reporter Recognizing GFP and mCherry Tags to Facilitate Studies of Protein–Protein Interactions

por Moustaqil, Mehdi, Bhumkar, Akshay, Gonzalez, Laura, Raoul, Lisa, Hunter, Dominic J. B., Carrive, Pascal, Sierecki, Emma, Gambin, Yann
Publicado 2017

Single-molecule detection on a portable 3D-printed microscope

por Brown, James W. P., Bauer, Arnaud, Polinkovsky, Mark E, Bhumkar, Akshay, Hunter, Dominic J. B., Gaus, Katharina, Sierecki, Emma, Gambin, Yann
Publicado 2019

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

por Leitão, André D. G., Rudolffi-Soto, Paulina, Chappard, Alexandre, Bhumkar, Akshay, Lau, Derrick, Hunter, Dominic J. B., Gambin, Yann, Sierecki, Emma
Publicado 2021

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

por Sierecki, Emma, Giles, Nichole, Bowden, Quill, Polinkovsky, Mark E., Steinbeck, Janina, Arrioti, Nicholas, Rahman, Diya, Bhumkar, Akshay, Nicovich, Philip R., Ross, Ian, Parton, Robert G., Böcking, Till, Gambin, Yann
Publicado 2016

Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor

por Moustaqil, Mehdi, Fontaine, Frank, Overman, Jeroen, McCann, Alex, Bailey, Timothy L, Rudolffi Soto, Paulina, Bhumkar, Akshay, Giles, Nichole, Hunter, Dominic J B, Gambin, Yann, Francois, Mathias, Sierecki, Emma
Publicado 2018

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

por Moustaqil, Mehdi, Ollivier, Emma, Chiu, Hsin-Ping, Van Tol, Sarah, Rudolffi-Soto, Paulina, Stevens, Christian, Bhumkar, Akshay, Hunter, Dominic J. B., Freiberg, Alexander N., Jacques, David, Lee, Benhur, Sierecki, Emma, Gambin, Yann
Publicado 2021