Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11

por Mukhopadhyay, Subhadip, Biancur, Douglas E., Parker, Seth J., Yamamoto, Keisuke, Banh, Robert S., Paulo, Joao A., Mancias, Joseph D., Kimmelman, Alec C.
Publicado 2021

Key clinical beam parameters for nanoparticle-mediated radiation dose amplification

por Detappe, Alexandre, Kunjachan, Sijumon, Drané, Pascal, Kotb, Shady, Myronakis, Marios, Biancur, Douglas E., Ireland, Thomas, Wagar, Matthew, Lux, Francois, Tillement, Olivier, Berbeco, Ross
Publicado 2016

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

por Mancias, Joseph D, Pontano Vaites, Laura, Nissim, Sahar, Biancur, Douglas E, Kim, Andrew J, Wang, Xiaoxu, Liu, Yu, Goessling, Wolfram, Kimmelman, Alec C, Harper, J Wade
Publicado 2015

Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption

por Virani, Needa A., Kelada, Olivia J., Kunjachan, Sijumon, Detappe, Alexandre, Kwon, Jihun, Hayashi, Jennifer, Vazquez-Pagan, Ana, Biancur, Douglas E., Ireland, Thomas, Kumar, Rajiv, Sridhar, Srinivas, Makrigiorgos, G. Mike, Berbeco, Ross I.
Publicado 2020

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

por Santana-Codina, Naiara, Gableske, Sebastian, del Rey, Maria Quiles, Małachowska, Beata, Jedrychowski, Mark P., Biancur, Douglas E., Schmidt, Paul J., Fleming, Mark D., Fendler, Wojciech, Harper, J. Wade, Kimmelman, Alec C., Mancias, Joseph D.
Publicado 2019

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

por Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Del Rey, Maria Quiles, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Publicado 2017

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

por Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Publicado 2017

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

por Yamamoto, Keisuke, Venida, Anthony, Yano, Julian, Biancur, Douglas E., Kakiuchi, Miwako, Gupta, Suprit, Sohn, Albert S.W., Mukhopadhyay, Subhadip, Lin, Elaine Y., Parker, Seth J., Banh, Robert S., Paulo, Joao A., Wen, Kwun Wah, Debnath, Jayanta, Kim, Grace E., Mancias, Joseph D., Fearon, Douglas T., Perera, Rushika M., Kimmelman, Alec C.
Publicado 2020

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

por Santana-Codina, Naiara, del Rey, Maria Quiles, Kapner, Kevin S., Zhang, Huan, Gikandi, Ajami, Malcolm, Callum, Poupault, Clara, Kuljanin, Miljan, John, Kristen M., Biancur, Douglas E., Chen, Brandon, Das, Nupur K., Lowder, Kristen E., Hennessey, Connor J., Huang, Wesley, Yang, Annan, Shah, Yatrik M., Nowak, Jonathan A., Aguirre, Andrew J., Mancias, Joseph D.
Publicado 2022