Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

por Bibby, Jack A., Purvis, Harriet A., Hayday, Thomas, Chandra, Anita, Okkenhaug, Klaus, Rosenzweig, Sofia, Aksentijevich, Ivona, Wood, Michael, Lachmann, Helen J., Kemper, Claudia, Cope, Andrew P., Perucha, Esperanza
Publicado 2020

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

por Purvis, Harriet A., Clarke, Fiona, Montgomery, Anna B., Colas, Chloe, Bibby, Jack A., Cornish, Georgina H., Dai, Xuezhi, Dudziak, Diana, Rawlings, David J., Zamoyska, Rose, Guermonprez, Pierre, Cope, Andrew P.
Publicado 2020

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells

por Clarke, Fiona, Jordan, Christine K., Gutiérrez-Martinez, Enrique, Bibby, Jack A., Sanchez-Blanco, Cristina, Cornish, Georgina H., Dai, Xuezhi, Rawlings, David J., Zamoyska, Rose, Guermonprez, Pierre, Cope, Andrew P., Purvis, Harriet A.
Publicado 2017

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

por Perucha, Esperanza, Melchiotti, Rossella, Bibby, Jack A, Wu, Wing, Frederiksen, Klaus Stensgaard, Roberts, Ceri A., Hall, Zoe, LeFriec, Gaelle, Robertson, Kevin A., Lavender, Paul, Gerwien, Jens Gammeltoft, Taams, Leonie S., Griffin, Julian L., de Rinaldis, Emanuele, van Baarsen, Lisa G. M., Kemper, Claudia, Ghazal, Peter, Cope, Andrew P.
Publicado 2019

Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

por West, Erin E., Merle, Nicolas S., Kamiński, Marcin M., Palacios, Gustavo, Kumar, Dhaneshwar, Wang, Luopin, Bibby, Jack A., Overdahl, Kirsten, Jarmusch, Alan K., Freeley, Simon, Lee, Duck-Yeon, Thompson, J. Will, Yu, Zu-Xi, Taylor, Naomi, Sitbon, Marc, Green, Douglas R., Bohrer, Andrea, Mayer-Barber, Katrin D., Afzali, Behdad, Kazemian, Majid, Scholl-Buergi, Sabine, Karall, Daniela, Huemer, Martina, Kemper, Claudia
Publicado 2023