Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

por MacLachlan, Timothy K., Milton, Mark N., Turner, Oliver, Tukov, Francis, Choi, Vivian W., Penraat, Jan, Delmotte, Marie-Hélène, Michaut, Lydia, Jaffee, Bruce D., Bigelow, Chad E.
Publicado 2017

ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp(rd6) mouse

por Sluch, Valentin M., Banks, Angela, Li, Hui, Crowley, Maura A., Davis, Vanessa, Xiang, Chuanxi, Yang, Junzheng, Demirs, John T., Vrouvlianis, Joanna, Leehy, Barrett, Hanks, Shawn, Hyman, Alexandra M., Aranda, Jorge, Chang, Bo, Bigelow, Chad E., Rice, Dennis S.
Publicado 2018

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

por Crowley, Maura A, Garland, Donita L, Sellner, Holger, Banks, Angela, Fan, Lin, Rejtar, Tomas, Buchanan, Natasha, Delgado, Omar, Xu, Yong Yao, Jose, Sandra, Adams, Christopher M, Mogi, Muneto, Wang, Karen, Bigelow, Chad E, Poor, Stephen, Anderson, Karen, Jaffee, Bruce D, Prasanna, Ganesh, Grosskreutz, Cynthia, Fernandez-Godino, Rosario, Pierce, Eric A, Dryja, Thaddeus P, Liao, Sha-Mei
Publicado 2022

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

por Choi, Vivian W, Bigelow, Chad E, McGee, Terri L, Gujar, Akshata N, Li, Hui, Hanks, Shawn M, Vrouvlianis, Joanna, Maker, Michael, Leehy, Barrett, Zhang, Yiqin, Aranda, Jorge, Bounoutas, George, Demirs, John T, Yang, Junzheng, Ornberg, Richard, Wang, Yu, Martin, Wendy, Stout, Kelly R, Argentieri, Gregory, Grosenstein, Paul, Diaz, Danielle, Turner, Oliver, Jaffee, Bruce D, Police, Seshidhar R, Dryja, Thaddeus P
Publicado 2015

Long-acting protein drugs for the treatment of ocular diseases

por Ghosh, Joy G., Nguyen, Andrew A., Bigelow, Chad E., Poor, Stephen, Qiu, Yubin, Rangaswamy, Nalini, Ornberg, Richard, Jackson, Brittany, Mak, Howard, Ezell, Tucker, Kenanova, Vania, de la Cruz, Elisa, Carrion, Ana, Etemad-Gilbertson, Bijan, Caro, Roxana Garcia, Zhu, Kan, George, Vinney, Bai, Jirong, Sharma-Nahar, Radhika, Shen, Siyuan, Wang, Yiqin, Subramanian, Kulandayan K., Fassbender, Elizabeth, Maker, Michael, Hanks, Shawn, Vrouvlianis, Joanna, Leehy, Barrett, Long, Debby, Prentiss, Melissa, Kansara, Viral, Jaffee, Bruce, Dryja, Thaddeus P., Roguska, Michael
Publicado 2017