Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability

por Vanhaesebroeck, Bart, Bilanges, Benoit, Madsen, Ralitsa R., Dale, Katie L., Lau, Evelyn, Vladimirou, Elina
Publicado 2019

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

por Foukas, Lazaros C, Bilanges, Benoit, Bettedi, Lucia, Pearce, Wayne, Ali, Khaled, Sancho, Sara, Withers, Dominic J, Vanhaesebroeck, Bart
Publicado 2013

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

por Alliouachene, Samira, Bilanges, Benoit, Chaussade, Claire, Pearce, Wayne, Foukas, Lazaros C., Scudamore, Cheryl L., Moniz, Larissa S., Vanhaesebroeck, Bart
Publicado 2016

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

por Varrault, Annie, Dantec, Christelle, Le Digarcher, Anne, Chotard, Laëtitia, Bilanges, Benoit, Parrinello, Hugues, Dubois, Emeric, Rialle, Stéphanie, Severac, Dany, Bouschet, Tristan, Journot, Laurent
Publicado 2017

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

por Posor, York, Kampyli, Charis, Bilanges, Benoit, Ganguli, Sushila, Koch, Philipp A., Wallroth, Alexander, Morelli, Daniele, Jenkins, Michalina, Alliouachene, Samira, Deltcheva, Elitza, Baum, Buzz, Haucke, Volker, Vanhaesebroeck, Bart
Publicado 2022

Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

por Grieco, Giuseppina, Janssens, Virginie, Gaide Chevronnay, Héloïse P., N’Kuli, Francisca, Van Der Smissen, Patrick, Wang, Tongsong, Shan, Jingdong, Vainio, Seppo, Bilanges, Benoit, Jouret, François, Vanhaesebroeck, Bart, Pierreux, Christophe E., Courtoy, Pierre J.
Publicado 2018

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

por Chung, Chih-Yao, Singh, Kritarth, Kotiadis, Vassilios N., Valdebenito, Gabriel E., Ahn, Jee Hwan, Topley, Emilie, Tan, Joycelyn, Andrews, William D., Bilanges, Benoit, Pitceathly, Robert D. S., Szabadkai, Gyorgy, Yuneva, Mariia, Duchen, Michael R.
Publicado 2021

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

por Alliouachene, Samira, Bilanges, Benoit, Chicanne, Gaëtan, Anderson, Karen E., Pearce, Wayne, Ali, Khaled, Valet, Colin, Posor, York, Low, Pei Ching, Chaussade, Claire, Scudamore, Cheryl L., Salamon, Rachel S., Backer, Jonathan M., Stephens, Len, Hawkins, Phill T., Payrastre, Bernard, Vanhaesebroeck, Bart
Publicado 2015

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

por Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
Publicado 2017

A small molecule PI3Kα activator for cardioprotection and neuroregeneration

por Gong, Grace Q, Bilanges, Benoit, Allsop, Ben, Masson, Glenn R, Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R, Conduit, Sarah E, Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H, Chan, AW Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A, Bunney, Tom D, Stephens, Len R, Hawkins, Phillip T, Katan, Matilda, Yellon, Derek M, Davidson, Sean M, Smith, David M, Phillips, James B, Angell, Richard, Williams, Roger L, Vanhaesebroeck, Bart
Publicado 2023