CLRM-03. BGB-290 AND TEMOZOLOMIDE IN TREATING ISOCITRATE DEHYDROGENASE (IDH)1/2-MUTANT GRADE I-IV GLIOMAS – A NOVEL MODEL OF AYA TRIAL DEVELOPMENT AND DEPLOYMENT

por Marks, Asher, Bindra, Ranjit
Publicado 2021

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

por Ganesa, Sachita, Sule, Amrita, Sundaram, Ranjini K., Bindra, Ranjit S.
Publicado 2022

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

por Bindra, Ranjit S., Goglia, Alexander G., Jasin, Maria, Powell, Simon N.
Publicado 2013

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

por Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
Publicado 2021

Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry

por Bao, Xun, Wu, Jianmei, Shuch, Brian, LoRusso, Patricia, Bindra, Ranjit S., Li, Jing
Publicado 2019

DNA polymerase beta participates in DNA End-joining

por Ray, Sreerupa, Breuer, Gregory, DeVeaux, Michelle, Zelterman, Daniel, Bindra, Ranjit, Sweasy, Joann B
Publicado 2018

Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors

por Sule, Amrita, Van Doorn, Jinny, Sundaram, Ranjini K, Ganesa, Sachita, Vasquez, Juan C, Bindra, Ranjit S
Publicado 2021

Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy

por Jairam, Vikram, Park, Henry S., Yu, James B., Bindra, Ranjit S., Contessa, Joseph N., Jethwa, Krishan R.
Publicado 2022

DNMT3A co-mutation in an IDH1-mutant glioblastoma

por Fomchenko, Elena I., Erson-Omay, E. Zeynep, Zhao, Amy, Bindra, Ranjit S., Huttner, Anita, Fulbright, Robert K., Moliterno, Jennifer
Publicado 2019

Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review

por Gallitto, Matthew, Lazarev, Stanislav, Wasserman, Isaac, Stafford, James M., Wolden, Suzanne L., Terezakis, Stephanie A., Bindra, Ranjit S., Bakst, Richard L.
Publicado 2019

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore

por Paradkar, Sateja, Herrington, James, Hendricson, Adam, Hewawasam, Piyasena, Plummer, Mark, Hoyer, Denton, Sundaram, Ranjini K., Surovtseva, Yulia V., Bindra, Ranjit S.
Publicado 2021

CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

por Chen, William S., Bindra, Ranjit S., Mo, Allen, Hayman, Thomas, Husain, Zain, Contessa, Joseph N., Gaffney, Stephen G., Townsend, Jeffrey P., Yu, James B.
Publicado 2018

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

por Wang, Yazhe, Malik, Shipra, Suh, Hee-Won, Xiao, Yong, Deng, Yanxiang, Fan, Rong, Huttner, Anita, Bindra, Ranjit S., Singh, Vijender, Saltzman, W. Mark, Bahal, Raman
Publicado 2023

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

por Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy
Publicado 2020

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

por Janssen, Aniek, Breuer, Gregory A., Brinkman, Eva K., van der Meulen, Annelot I., Borden, Sean V., van Steensel, Bas, Bindra, Ranjit S., LaRocque, Jeannine R., Karpen, Gary H.
Publicado 2016

Oncometabolites suppress DNA repair by disrupting local chromatin signaling

por Sulkowski, Parker L., Oeck, Sebastian, Dow, Jonathan, Economos, Nicholas G., Mirfakhraie, Lily, Liu, Yanfeng, Noronha, Katelyn, Bao, Xun, Li, Jing, Shuch, Brian M., King, Megan C., Bindra, Ranjit S., Glazer, Peter M.
Publicado 2020

Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma

por Fanucci, Kristina, Pilat, Mary Jo, Shyr, Derek, Shyr, Yu, Boerner, Scott, Li, Jing, Durecki, Diane, Drappatz, Jan, Puduvalli, Vinay, Lieberman, Frank Scott, Gonzalez, Javier, Giglio, Pierre, Ivy, S. Percy, Bindra, Ranjit S., Omuro, Antonio, LoRusso, Patricia
Publicado 2023

Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects

por Sulkowski, Parker L., Sundaram, Ranjini K., Oeck, Sebastian, Corso, Christopher D., Liu, Yanfeng, Noorbakhsh, Seth, Niger, Monica, Boeke, Marta, Ueno, Daiki, Kalathil, Aravind Nambiar, Bao, Xun, Li, Jing, Shuch, Brian, Bindra, Ranjit S., Glazer, Peter M.
Publicado 2018

Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma

por Hong, Christopher S., Vasquez, Juan C., Kundishora, Adam J., Elsamadicy, Aladine A., Beckta, Jason M., Sule, Amrita, Marks, Asher M., Leelatian, Nalin, Huttner, Anita, Bindra, Ranjit S., DiLuna, Michael L., Kahle, Kristopher T., Erson-Omay, E. Zeynep
Publicado 2020

In Vivo Anti-Tumor Effect of PARP Inhibition in IDH1/2 Mutant MDS/AML Resistant to Targeted Inhibitors of Mutant IDH1/2

por Gbyli, Rana, Song, Yuanbin, Liu, Wei, Gao, Yimeng, Biancon, Giulia, Chandhok, Namrata S, Wang, Xiaman, Fu, Xiaoying, Patel, Amisha, Sundaram, Ranjini, Tebaldi, Toma, Mamillapalli, Padmavathi, Zeidan, Amer M, Flavell, Richard A., Prebet, Thomas, Bindra, Ranjit S., Halene, Stephanie
Publicado 2022