The role of metabolism in cellular processes

por Birsoy, Kivanc, Sancak, Yasemin
Publicado 2019

Targeting extracellular nutrient dependencies of cancer cells

por Garcia-Bermudez, Javier, Williams, Robert T., Guarecuco, Rohiverth, Birsoy, Kıvanç
Publicado 2019

The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine

por Chidley, Christopher, Trauger, Sunia A, Birsoy, Kıvanç, O'Shea, Erin K
Publicado 2016

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

por Son, Yeeun, Kenny, Timothy C., Khan, Artem, Birsoy, Kivanç, Hite, Richard K.
Publicado 2023

A critical role for mTORC1 in erythropoiesis and anemia

por Knight, Zachary A, Schmidt, Sarah F, Birsoy, Kivanc, Tan, Keith, Friedman, Jeffrey M
Publicado 2014

Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression

por Lu, Yi-Hsueh, Dallner, Olof Stefan, Birsoy, Kivanc, Fayzikhodjaeva, Gulya, Friedman, Jeffrey M.
Publicado 2015

Spotlight on GOT2 in Cancer Metabolism

por Kerk, Samuel A, Garcia-Bermudez, Javier, Birsoy, Kivanc, Sherman, Mara H, Shah, Yatrik M, Lyssiotis, Costas A
Publicado 2023

A CRISPR screen identifies a pathway required for paraquat-induced cell death

por Reczek, Colleen R., Birsoy, Kıvanç, Kong, Hyewon, Martínez-Reyes, Inmaculada, Wang, Tim, Gao, Peng, Sabatini, David M., Chandel, Navdeep S.
Publicado 2017

Limitation of adipose tissue by the number of embryonic progenitor cells

por Hedbacker, Kristina, Lu, Yi-Hsueh, Dallner, Olof, Li, Zhiying, Fayzikhodjaeva, Gulya, Birsoy, Kıvanç, Han, Chiayun, Yang, Chingwen, Friedman, Jeffrey M
Publicado 2020

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

por Birsoy, Kıvanç, Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary B., Sabatini, David M.
Publicado 2014

Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells

por Guarecuco, Rohiverth, Williams, Robert T., Baudrier, Lou, La, Konnor, Passarelli, Maria C., Ekizoglu, Naz, Mestanoglu, Mert, Alwaseem, Hanan, Rostandy, Bety, Fidelin, Justine, Garcia-Bermudez, Javier, Molina, Henrik, Birsoy, Kıvanç
Publicado 2020

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

por Garcia-Bermudez, Javier, Baudrier, Lou, La, Konnor, Zhu, Xiphias Ge, Fidelin, Justine, Sviderskiy, Vladislav O, Papagiannakopoulos, Thales, Molina, Henrik, Snuderl, Matija, Lewis, Caroline A., Possemato, Richard L., Birsoy, Kıvanç
Publicado 2018

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

por Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Yilmaz, Omer H., Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Peterson, Tim R., Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary B., Sabatini, David M.
Publicado 2012

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

por Garcia-Bermudez, Javier, Baudrier, Lou, Can Bayraktar, Erol, Shen, Yihui, La, Konnor, Guarecuco, Rohiverth, Yucel, Burcu, Fiore, Danilo, Tavora, Bernardo, Freinkman, Elizaveta, Ham Chan, Sze, Lewis, Caroline, Min, Wei, Inghirami, Giorgio, Sabatini, David M, Birsoy, Kıvanç
Publicado 2019

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

por Yilmaz, Ömer H., Katajisto, Pekka, Lamming, Dudley W., Gültekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zukerberg, Lawrence, Bhan, Atul, Deshpande, Vikram, Sabatini, David M.
Publicado 2012

Metabolic co-essentiality mapping identifies c12orf49 as a regulator of SREBP processing and cholesterol metabolism

por Bayraktar, Erol C., La, Konnor, Karpman, Kara, Unlu, Gokhan, Ozerdem, Ceren, Ritter, Dylan J., Alwaseem, Hanan, Molina, Henrik, Hoffmann, Hans-Heinrich, Millner, Alec, Atilla-Gokcumen, G. Ekin, Gamazon, Eric R., Rushing, Amy R., Knapik, Ela W., Basu, Sumanta, Birsoy, Kıvanç
Publicado 2020

Amplification of Adipogenic Commitment by VSTM2A

por Secco, Blandine, Camiré, Étienne, Brière, Marc-Antoine, Caron, Alexandre, Billong, Armande, Gélinas, Yves, Lemay, Anne-Marie, Tharp, Kevin M., Lee, Peter L., Gobeil, Stéphane, Guimond, Jean V., Patey, Natacha, Guertin, David A., Stahl, Andreas, Haddad, Élie, Marsolais, David, Bossé, Yohan, Birsoy, Kivanc, Laplante, Mathieu
Publicado 2017

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

por Peng, Xinxin, Chen, Zhongyuan, Farshidfar, Farshad, Xu, Xiaoyan, Lorenzi, Philip L., Wang, Yumeng, Cheng, Feixiong, Tan, Lin, Mojumdar, Kamalika, Du, Di, Ge, Zhongqi, Li, Jun, Thomas, George V., Birsoy, Kivanc, Liu, Lingxiang, Zhang, Huiwen, Zhao, Zhongming, Marchand, Calena, Weinstein, John N., Bathe, Oliver F., Liang, Han
Publicado 2018

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

por Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Publicado 2015

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

por Possemato, Richard, Marks, Kevin M., Shaul, Yoav D., Pacold, Michael E., Kim, Dohoon, Birsoy, Kivanç, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing, Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Sabatini, David M.
Publicado 2011