Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth

por Biscans, Annabelle
Publicado 2018

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

por Mangla, Priyanka, Vicentini, Quentin, Biscans, Annabelle
Publicado 2023

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

por Biscans, Annabelle, Caiazzi, Jillian, Davis, Sarah, McHugh, Nicholas, Sousa, Jacquelyn, Khvorova, Anastasia
Publicado 2020

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

por Biscans, Annabelle, Caiazzi, Jillian, McHugh, Nicholas, Hariharan, Vignesh, Muhuri, Manish, Khvorova, Anastasia
Publicado 2021

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

por Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia
Publicado 2019

Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo

por Segal, Meirav, Biscans, Annabelle, Gilles, Maud-Emmanuelle, Anastasiadou, Eleni, De Luca, Roberto, Lim, Jihoon, Khvorova, Anastasia, Slack, Frank J.
Publicado 2019

Innovative developments and emerging technologies in RNA therapeutics

por Halloy, François, Biscans, Annabelle, Bujold, Katherine E., Debacker, Alexandre, Hill, Alyssa C., Lacroix, Aurélie, Luige, Olivia, Strömberg, Roger, Sundstrom, Linda, Vogel, Jörg, Ghidini, Alice
Publicado 2022

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

por Davis, Sarah M., Hariharan, Vignesh N., Lo, Agnes, Turanov, Anton A., Echeverria, Dimas, Sousa, Jacquelyn, McHugh, Nicholas, Biscans, Annabelle, Alterman, Julia F., Karumanchi, S. Ananth, Moore, Melissa J., Khvorova, Anastasia
Publicado 2022

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

por Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Publicado 2019

RNAi-based modulation of IFN-γ signaling in skin

por Tang, Qi, Sousa, Jacquelyn, Echeverria, Dimas, Fan, Xueli, Hsueh, Ying-Chao, Afshari, Khashayar, MeHugh, Nicholas, Cooper, David A., Vangjeli, Lorenc, Monopoli, Kathryn, Okamura, Ken, Biscans, Annabelle, Clauss, Adam, Harris, John E., Khvorova, Anastasia
Publicado 2022

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

por Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia
Publicado 2022

Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity

por Lim, Wooi F., Forouhan, Mitra, Roberts, Thomas C., Dabney, Jesse, Ellerington, Ruth, Speciale, Alfina A., Manzano, Raquel, Lieto, Maria, Sangha, Gavinda, Banerjee, Subhashis, Conceição, Mariana, Cravo, Lara, Biscans, Annabelle, Roux, Loïc, Pourshafie, Naemeh, Grunseich, Christopher, Duguez, Stephanie, Khvorova, Anastasia, Pennuto, Maria, Cortes, Constanza J., La Spada, Albert R., Fischbeck, Kenneth H., Wood, Matthew J.A., Rinaldi, Carlo
Publicado 2021

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

por Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, Harris, John E.
Publicado 2023

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

por Hariharan, Vignesh N., Shin, Minwook, Chang, Ching-Wen, O’Reilly, Daniel, Biscans, Annabelle, Yamada, Ken, Guo, Zhiru, Somasundaran, Mohan, Tang, Qi, Monopoli, Kathryn, Krishnamurthy, Pranathi Meda, Devi, Gitali, McHugh, Nicholas, Cooper, David A., Echeverria, Dimas, Cruz, John, Chan, Io Long, Liu, Ping, Lim, Sun-Young, McConnell, Jill, Singh, Satya Prakash, Hildebrand, Samuel, Sousa, Jacquelyn, Davis, Sarah M., Kennedy, Zachary, Ferguson, Chantal, Godinho, Bruno M. D. C., Thillier, Yann, Caiazzi, Jillian, Ly, Socheata, Muhuri, Manish, Kelly, Karen, Humphries, Fiachra, Cousineau, Alyssa, Parsi, Krishna Mohan, Li, Qi, Wang, Yang, Maehr, René, Gao, Guangping, Korkin, Dmitry, McDougall, William M., Finberg, Robert W., Fitzgerald, Katherine A., Wang, Jennifer P., Watts, Jonathan K., Khvorova, Anastasia
Publicado 2023