Using CRISPR/Cas9 to model human liver disease

por Alves-Bezerra, Michele, Furey, Nika, Johnson, Collin G., Bissig, Karl-Dimiter
Publicado 2019

PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma

por Valanejad, Leila, Cast, Ashley, Wright, Mary, Bissig, Karl-Dimiter, Karns, Rebekah, Weirauch, Matthew T., Timchenko, Nikolai
Publicado 2018

In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy

por Kruse, Robert L., Shum, Thomas, Legras, Xavier, Barzi, Mercedes, Pankowicz, Frank P., Gottschalk, Stephen, Bissig, Karl-Dimiter
Publicado 2017

The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice

por Qin, Xuan, Xie, Cen, Hakenjos, John M., MacKenzie, Kevin R., Boyd, Shelton R., Barzi, Mercedes, Bissig, Karl-Dimiter, Young, Damian W., Li, Feng
Publicado 2023

Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells

por Velasquez-Mao, Aaron J., Tsao, Christopher J. M., Monroe, Madeline N., Legras, Xavier, Bissig-Choisat, Beatrice, Bissig, Karl-Dimiter, Ruano, Rodrigo, Jacot, Jeffrey G.
Publicado 2017

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

por Minor, Marissa M., Hollinger, F. Blaine, McNees, Adrienne L., Jung, Sung Yun, Jain, Antrix, Hyser, Joseph M., Bissig, Karl-Dimiter, Slagle, Betty L.
Publicado 2020

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

por Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Publicado 2017

Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism

por Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Publicado 2017

A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

por Kruse, Robert L., Barzi, Mercedes, Legras, Xavier, Pankowicz, Francis P., Furey, Nika, Liao, Lan, Xu, Janming, Bissig-Choisat, Beatrice, Slagle, Betty L., Bissig, Karl-Dimiter
Publicado 2021

Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice

por Shih, Yao-Ming, Sun, Cheng-Pu, Chou, Hui-Hsien, Wu, Tzu-Hui, Chen, Chun-Chi, Wu, Ping-Yi, Enya Chen, Yu-Chen, Bissig, Karl-Dimiter, Tao, Mi-Hua
Publicado 2015

Targeting the Apoa1 locus for liver-directed gene therapy

por De Giorgi, Marco, Li, Ang, Hurley, Ayrea, Barzi, Mercedes, Doerfler, Alexandria M., Cherayil, Nikitha A., Smith, Harrison E., Brown, Jonathan D., Lin, Charles Y., Bissig, Karl-Dimiter, Bao, Gang, Lagor, William R.
Publicado 2021

Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia

por Pankowicz, Francis P., Barzi, Mercedes, Legras, Xavier, Hubert, Leroy, Mi, Tian, Tomolonis, Julie A., Ravishankar, Milan, Sun, Qin, Yang, Diane, Borowiak, Malgorzata, Sumazin, Pavel, Elsea, Sarah H., Bissig-Choisat, Beatrice, Bissig, Karl-Dimiter
Publicado 2016

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

por Jarrett, Kelsey E., Lee, Ciaran M., Yeh, Yi-Hsien, Hsu, Rachel H., Gupta, Rajat, Zhang, Min, Rodriguez, Perla J., Lee, Chang Seok, Gillard, Baiba K., Bissig, Karl-Dimiter, Pownall, Henry J., Martin, James F., Bao, Gang, Lagor, William R.
Publicado 2017

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice

por Qin, Xuan, Hakenjos, John M., MacKenzie, Kevin R., Barzi, Mercedes, Chavan, Hemantkumar, Nyshadham, Pranavanand, Wang, Jin, Jung, Sung Yun, Guner, Joie Z., Chen, Si, Guo, Lei, Krishnamurthy, Partha, Bissig, Karl-Dimiter, Palmer, Stephen, Matzuk, Martin M., Li, Feng
Publicado 2022

A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma

por Woodfield, Sarah E., Shi, Yan, Patel, Roma H., Jin, Jingling, Major, Angela, Sarabia, Stephen F., Starosolski, Zbigniew, Zorman, Barry, Gupta, Siddharth S., Chen, Zhenghu, Ibarra, Aryana M., Bissig, Karl-Dimiter, Ghaghada, Ketan B., Sumazin, Pavel, López-Terrada, Dolores, Vasudevan, Sanjeev A.
Publicado 2017

Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model

por Bissig-Choisat, Beatrice, Wang, Lili, Legras, Xavier, Saha, Pradip K., Chen, Leon, Bell, Peter, Pankowicz, Francis P., Hill, Matthew C., Barzi, Mercedes, Leyton, Claudia Kettlun, Leung, Hon-Chiu Eastwood, Kruse, Robert L., Himes, Ryan W., Goss, John A., Wilson, James M., Chan, Lawrence, Lagor, William R., Bissig, Karl-Dimiter
Publicado 2015

A human liver chimeric mouse model for non-alcoholic fatty liver disease

por Bissig-Choisat, Beatrice, Alves-Bezerra, Michele, Zorman, Barry, Ochsner, Scott A., Barzi, Mercedes, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Dean, Adam M., York, Robert B., Galvan, N. Thao N., Goss, John, Lagor, William R., Moore, David D., Cohen, David E., McKenna, Neil J., Sumazin, Pavel, Bissig, Karl-Dimiter
Publicado 2021

Innovations, challenges, and minimal information for standardization of humanized mice

por Stripecke, Renata, Münz, Christian, Schuringa, Jan Jacob, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard
Publicado 2020

Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop

por Akkina, Ramesh, Barber, Daniel L., Bility, Moses T., Bissig, Karl-Dimiter, Burwitz, Benjamin J., Eichelberg, Katrin, Endsley, Janice J., Garcia, J. Victor, Hafner, Richard, Karakousis, Petros C., Korba, Brent E., Koshy, Rajen, Lambros, Chris, Menne, Stephan, Nuermberger, Eric L., Ploss, Alexander, Podell, Brendan K., Poluektova, Larisa Y., Sanders-Beer, Brigitte E., Subbian, Selvakumar, Wahl, Angela
Publicado 2020

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

por De Giorgi, Marco, Park, So Hyun, Castoreno, Adam, Cao, Mingming, Hurley, Ayrea, Saxena, Lavanya, Chuecos, Marcel A., Walkey, Christopher J., Doerfler, Alexandria M., Furgurson, Mia N., Ljungberg, M. Cecilia, Patel, Kalyani R., Hyde, Sarah, Chickering, Tyler, Lefebvre, Stephanie, Wassarman, Kelly, Miller, Patrick, Qin, June, Schlegel, Mark K., Zlatev, Ivan, Li, Rich Gang, Kim, Jong, Martin, James F., Bissig, Karl-Dimiter, Jadhav, Vasant, Bao, Gang, Lagor, William R.
Publicado 2023