Streptococcal Enzymes as Precision Tools Against Pathogenic IgG Autoantibodies in Small Vessel Vasculitis

por Segelmark, Mårten, Björck, Lars
Publicado 2019

IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential

por Johansson, Björn P., Shannon, Oonagh, Björck, Lars
Publicado 2008

Finegoldia magna, an Anaerobic Gram-Positive Bacterium of the Normal Human Microbiota, Induces Inflammation by Activating Neutrophils

por Neumann, Ariane, Björck, Lars, Frick, Inga-Maria
Publicado 2020

IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies

por Frick, Inga-Maria, Happonen, Lotta, Wrighton, Sebastian, Nordenfelt, Pontus, Björck, Lars
Publicado 2023

Severe Lung Lesions Caused by Salmonella Are Prevented by Inhibition of the Contact System

por Persson, Kristin, Mörgelin, Matthias, Lindbom, Lennart, Alm, Per, Björck, Lars, Herwald, Heiko
Publicado 2000

Streptococcal inhibitor of complement (SIC) modulates fibrinolysis and enhances bacterial survival within fibrin clots

por Frick, Inga-Maria, Shannon, Oonagh, Neumann, Ariane, Karlsson, Christofer, Wikström, Mats, Björck, Lars
Publicado 2018

Streptococcal protein SIC activates monocytes and induces inflammation

por Neumann, Ariane, Happonen, Lotta, Karlsson, Christofer, Bahnan, Wael, Frick, Inga-Maria, Björck, Lars
Publicado 2021

Antibody orientation at bacterial surfaces is related to invasive infection

por Nordenfelt, Pontus, Waldemarson, Sofia, Linder, Adam, Mörgelin, Matthias, Karlsson, Christofer, Malmström, Johan, Björck, Lars
Publicado 2012

Antibacterial Activity of the Contact and Complement Systems Is Blocked by SIC, a Protein Secreted by Streptococcus pyogenes

por Frick, Inga-Maria, Shannon, Oonagh, Åkesson, Per, Mörgelin, Matthias, Collin, Mattias, Schmidtchen, Artur, Björck, Lars
Publicado 2011

Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes

por Diehl, Carl, Wisniewska, Magdalena, Frick, Inga-Maria, Streicher, Werner, Björck, Lars, Malmström, Johan, Wikström, Mats
Publicado 2016

Antibodies against a Surface Protein of Streptococcus pyogenes Promote a Pathological Inflammatory Response

por Kahn, Fredrik, Mörgelin, Matthias, Shannon, Oonagh, Norrby-Teglund, Anna, Herwald, Heiko, Olin, Anders I., Björck, Lars
Publicado 2008

Identification of molecular mechanisms used by Finegoldia magna to penetrate and colonize human skin

por Murphy, Elizabeth C, Mörgelin, Matthias, Reinhardt, Dieter P, Olin, Anders I, Björck, Lars, Frick, Inga-Maria
Publicado 2014

Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion

por Wollein Waldetoft, Kristofer, Mohanty, Tirthankar, Karlsson, Christofer, Mörgelin, Matthias, Frick, Inga-Maria, Malmström, Johan, Björck, Lars
Publicado 2016

Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS

por Karlsson, Christofer A. Q., Järnum, Sofia, Winstedt, Lena, Kjellman, Christian, Björck, Lars, Linder, Adam, Malmström, Johan A.
Publicado 2018

SufA – a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation

por Karlsson, Christofer, Mörgelin, Matthias, Collin, Mattias, Lood, Rolf, Andersson, Marie-Louise, Schmidtchen, Artur, Björck, Lars, Frick, Inga-Maria
Publicado 2009

Streptococcal Surface Proteins Activate the Contact System and Control Its Antibacterial Activity

por Wollein Waldetoft, Kristofer, Svensson, Lisbeth, Mörgelin, Matthias, Olin, Anders I., Nitsche-Schmitz, D. Patric, Björck, Lars, Frick, Inga-Maria
Publicado 2012

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus

por Ermert, David, Laabei, Maisem, Weckel, Antonin, Mörgelin, Matthias, Lundqvist, Martin, Björck, Lars, Ram, Sanjay, Linse, Sara, Blom, Anna M.
Publicado 2019

Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen

por Frick, Inga-Maria, Karlsson, Christofer, Mörgelin, Matthias, Olin, Anders I, Janjusevic, Radmila, Hammarström, Clara, Holst, Elisabet, de Château, Maarten, Björck, Lars
Publicado 2008

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production

por Westman, Johannes, Chakrakodi, Bhavya, Snäll, Johanna, Mörgelin, Matthias, Bruun Madsen, Martin, Hyldegaard, Ole, Neumann, Ariane, Frick, Inga-Maria, Norrby-Teglund, Anna, Björck, Lars, Herwald, Heiko
Publicado 2018

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity

por Winstedt, Lena, Järnum, Sofia, Nordahl, Emma Andersson, Olsson, Andreas, Runström, Anna, Bockermann, Robert, Karlsson, Christofer, Malmström, Johan, Palmgren, Gabriella Samuelsson, Malmqvist, Ulf, Björck, Lars, Kjellman, Christian
Publicado 2015