A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpress(TM)

por Nowicki, Matthew W., Blackburn, Elizabeth A., McNae, Iain W., Wear, Martin A.
Publicado 2015

Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200

por Wear, Martin A., Nowicki, Matthew W., Blackburn, Elizabeth A., McNae, Iain W., Walkinshaw, Malcolm D.
Publicado 2017

Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

por Gur, Mert, Blackburn, Elizabeth A., Ning, Jia, Narayan, Vikram, Ball, Kathryn L., Walkinshaw, Malcolm D., Erman, Burak
Publicado 2018

Inhibition of Antigen-Specific and Nonspecific Stimulation of Bovine T and B Cells by Lymphostatin from Attaching and Effacing Escherichia coli

por Cassady-Cain, Robin L., Blackburn, Elizabeth A., Bell, Charlotte R., Elshina, Elizaveta, Hope, Jayne C., Stevens, Mark P.
Publicado 2017

Activity of Lymphostatin, A Lymphocyte Inhibitory Virulence Factor of Pathogenic Escherichia coli, is Dependent on a Cysteine Protease Motif

por Bease, Andrew G., Blackburn, Elizabeth A., Chintoan-Uta, Cosmin, Webb, Shaun, Cassady-Cain, Robin L., Stevens, Mark P.
Publicado 2021

UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1

por Shave, Steven, Blackburn, Elizabeth A., Adie, Jillian, Houston, Douglas R., Auer, Manfred, Webster, Scott P., Taylor, Paul, Walkinshaw, Malcolm D.
Publicado 2015

Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90

por Blackburn, Elizabeth A., Wear, Martin A., Landré, Vivian, Narayan, Vikram, Ning, Jia, Erman, Burak, Ball, Kathryn L., Walkinshaw, Malcolm D.
Publicado 2015

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment

por Legal, Thibault, Hayward, Daniel, Gluszek-Kustusz, Agata, Blackburn, Elizabeth A., Spanos, Christos, Rappsilber, Juri, Gruneberg, Ulrike, Welburn, Julie P. I.
Publicado 2020

Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)

por Narayan, Vikram, Landré, Vivien, Ning, Jia, Hernychova, Lenka, Muller, Petr, Verma, Chandra, Walkinshaw, Malcolm D., Blackburn, Elizabeth A., Ball, Kathryn L.
Publicado 2015

Biophysical Characterization and Activity of Lymphostatin, a Multifunctional Virulence Factor of Attaching and Effacing Escherichia coli

por Cassady-Cain, Robin L., Blackburn, Elizabeth A., Alsarraf, Husam, Dedic, Emil, Bease, Andrew G., Böttcher, Bettina, Jørgensen, René, Wear, Martin, Stevens, Mark P.
Publicado 2016

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

por Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Publicado 2018

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

por Mitchell, Alice Rose, Yuan, Meng, Morgan, Hugh P., McNae, Iain W., Blackburn, Elizabeth A., Le Bihan, Thierry, Homem, Rafael A., Yu, Manda, Loake, Gary J., Michels, Paul A., Wear, Martin A., Walkinshaw, Malcolm D.
Publicado 2018

Discovery of a novel ligand that modulates the protein–protein interactions of the AAA+ superfamily oncoprotein reptin

por Healy, Alan R., Houston, Douglas R., Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M., Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A., Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D., Westwood, Nicholas J., Hupp, Ted R.
Publicado 2015

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

por De Simone, Alessio, Georgiou, Charis, Ioannidis, Harris, Gupta, Arun A., Juárez-Jiménez, Jordi, Doughty-Shenton, Dahlia, Blackburn, Elizabeth A., Wear, Martin A., Richards, Jonathan P., Barlow, Paul N., Carragher, Neil, Walkinshaw, Malcolm D., Hulme, Alison N., Michel, Julien
Publicado 2018

The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution

por Soares, Dinesh C., Bradshaw, Nicholas J., Zou, Juan, Kennaway, Christopher K., Hamilton, Russell S., Chen, Zhuo A., Wear, Martin A., Blackburn, Elizabeth A., Bramham, Janice, Böttcher, Bettina, Millar, J. Kirsty, Barlow, Paul N., Walkinshaw, Malcolm D., Rappsilber, Juri, Porteous, David J.
Publicado 2012

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondria...

por Eykelenboom, Jennifer E., Briggs, Gareth J., Bradshaw, Nicholas J., Soares, Dinesh C., Ogawa, Fumiaki, Christie, Sheila, Malavasi, Elise L.V., Makedonopoulou, Paraskevi, Mackie, Shaun, Malloy, Mary P., Wear, Martin A., Blackburn, Elizabeth A., Bramham, Janice, McIntosh, Andrew M., Blackwood, Douglas H., Muir, Walter J., Porteous, David J., Millar, J. Kirsty
Publicado 2012

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

por McNae, Iain W., Kinkead, James, Malik, Divya, Yen, Li-Hsuan, Walker, Martin K., Swain, Chris, Webster, Scott P., Gray, Nick, Fernandes, Peter M., Myburgh, Elmarie, Blackburn, Elizabeth A., Ritchie, Ryan, Austin, Carol, Wear, Martin A., Highton, Adrian J., Keats, Andrew J., Vong, Antonio, Dornan, Jacqueline, Mottram, Jeremy C., Michels, Paul A. M., Pettit, Simon, Walkinshaw, Malcolm D.
Publicado 2021