TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

por Broderick, Ronan, Nieminuszczy, Jadwiga, Blackford, Andrew N, Winczura, Alicja, Niedzwiedz, Wojciech
Publicado 2015

TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

por Blackford, Andrew N., Nieminuszczy, Jadwiga, Schwab, Rebekka A., Galanty, Yaron, Jackson, Stephen P., Niedzwiedz, Wojciech
Publicado 2015

USP4 Auto-Deubiquitylation Promotes Homologous Recombination

por Wijnhoven, Paul, Konietzny, Rebecca, Blackford, Andrew N., Travers, Jonathan, Kessler, Benedikt M., Nishi, Ryotaro, Jackson, Stephen P.
Publicado 2015

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks

por Shorrocks, Ann-Marie K., Jones, Samuel E., Tsukada, Kaima, Morrow, Carl A., Belblidia, Zoulikha, Shen, Johanna, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt M., Blackford, Andrew N.
Publicado 2021

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

por Lescale, Chloé, Lenden Hasse, Hélène, Blackford, Andrew N., Balmus, Gabriel, Bianchi, Joy J., Yu, Wei, Bacoccina, Léa, Jarade, Angélique, Clouin, Christophe, Sivapalan, Rohan, Reina-San-Martin, Bernardo, Jackson, Stephen P., Deriano, Ludovic
Publicado 2016

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

por Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross
Publicado 2018

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

por De Marco Zompit, Mara, Esteban, Mònica Torres, Mooser, Clémence, Adam, Salomé, Rossi, Silvia Emma, Jeanrenaud, Alain, Leimbacher, Pia-Amata, Fink, Daniel, Shorrocks, Ann-Marie K., Blackford, Andrew N., Durocher, Daniel, Stucki, Manuel
Publicado 2022

Synthetic lethality between PAXX and XLF in mammalian development

por Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Publicado 2016

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

por Mooser, Clémence, Symeonidou, Ioanna-Eleni, Leimbacher, Pia-Amata, Ribeiro, Alison, Shorrocks, Ann-Marie K., Jungmichel, Stephanie, Larsen, Sara C., Knechtle, Katja, Jasrotia, Arti, Zurbriggen, Diana, Jeanrenaud, Alain, Leikauf, Colin, Fink, Daniel, Nielsen, Michael L., Blackford, Andrew N., Stucki, Manuel
Publicado 2020

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

por Leimbacher, Pia-Amata, Jones, Samuel E., Shorrocks, Ann-Marie K., de Marco Zompit, Mara, Day, Matthew, Blaauwendraad, Jordy, Bundschuh, Diana, Bonham, Sarah, Fischer, Roman, Fink, Daniel, Kessler, Benedikt M., Oliver, Antony W., Pearl, Laurence H., Blackford, Andrew N., Stucki, Manuel
Publicado 2019

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

por Groelly, Florian J., Dagg, Rebecca A., Petropoulos, Michalis, Rossetti, Giacomo G., Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E., Ochs, Fena, Dionellis, Vasilis S., Puig Lombardi, Emilia, Miossec, Matthieu J., Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N., Altmeyer, Matthias, Halazonetis, Thanos D., Tarsounas, Madalena
Publicado 2022

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions

por Ochi, Takashi, Quarantotti, Valentina, Lin, Huawen, Jullien, Jerome, Rosa e Silva, Ivan, Boselli, Francesco, Barnabas, Deepak D., Johnson, Christopher M., McLaughlin, Stephen H., Freund, Stefan M.V., Blackford, Andrew N., Kimata, Yuu, Goldstein, Raymond E., Jackson, Stephen P., Blundell, Tom L., Dutcher, Susan K., Gergely, Fanni, van Breugel, Mark
Publicado 2020

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

por Hodson, Charlotte, Low, Jason K. K., van Twest, Sylvie, Jones, Samuel E., Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K., O’Rourke, Julienne J., Parker, Benjamin L., Glaser, Astrid, Parker, Michael W., Mackay, Joel P., Blackford, Andrew N., Costa, Alessandro, Deans, Andrew J.
Publicado 2022

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

por Harley, Margaret E., Murina, Olga, Leitch, Andrea, Higgs, Martin R., Bicknell, Louise S., Yigit, Gökhan, Blackford, Andrew N., Zlatanou, Anastasia, Mackenzie, Karen J., Reddy, Kaalak, Halachev, Mihail, McGlasson, Sarah, Reijns, Martin A. M., Fluteau, Adeline, Martin, Carol-Anne, Sabbioneda, Simone, Elcioglu, Nursel H., Altmüller, Janine, Thiele, Holger, Greenhalgh, Lynn, Chessa, Luciana, Maghnie, Mohamad, Salim, Mahmoud, Bober, Michael B., Nürnberg, Peter, Jackson, Stephen P., Hurles, Matthew E., Wollnik, Bernd, Stewart, Grant S., Jackson, Andrew P.
Publicado 2015

PGBD5 promotes site-specific oncogenic mutations in human tumors

por Henssen, Anton G., Koche, Richard, Zhuang, Jiali, Jiang, Eileen, Reed, Casie, Eisenberg, Amy, Still, Eric, MacArthur, Ian C., Rodríguez-Fos, Elias, Gonzalez, Santiago, Puiggròs, Montserrat, Blackford, Andrew N., Mason, Christopher E., de Stanchina, Elisa, Gönen, Mithat, Emde, Anne-Katrin, Shah, Minita, Arora, Kanika, Reeves, Catherine, Socci, Nicholas D., Perlman, Elizabeth, Antonescu, Cristina R., Roberts, Charles W. M., Steen, Hanno, Mullen, Elizabeth, Jackson, Stephen P., Torrents, David, Weng, Zhiping, Armstrong, Scott A., Kentsis, Alex
Publicado 2017