The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

por Serwetnyk, Michael A., Blagg, Brian S.J.
Publicado 2021

Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun

por Li, Chengyuan, Ma, Jiacheng, Zhao, Huiping, Blagg, Brian S.J, Dobrowsky, Rick T
Publicado 2012

Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors

por Rahmy, Sharif, Mishra, Sanket J., Murphy, Sean, Blagg, Brian S. J., Lu, Xin
Publicado 2022

Cruentaren A Binds F(1)F(0) ATP Synthase To Modulate the Hsp90 Protein Folding Machinery

por Hall, Jessica A., Kusuma, Bhaskar Reddy, Brandt, Gary E. L., Blagg, Brian S. J.
Publicado 2014

The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

por Lei, Wei, Duron, David I., Stine, Carrie, Mishra, Sanket, Blagg, Brian S. J., Streicher, John M.
Publicado 2019

Catalysis-Enabled Access to Cryptic Geldanamycin Oxides

por Hilton, Margaret J., Brackett, Christopher M., Mercado, Brandon Q., Blagg, Brian S. J., Miller, Scott J.
Publicado 2020

High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

por Davenport, Jason, Balch, Maurie, Galam, Lakshmi, Girgis, Antwan, Hall, Jessica, Blagg, Brian S. J., Matts, Robert L.
Publicado 2014

KU-32, a Novel Drug for Diabetic Neuropathy, Is Safe for Human Islets and Improves In Vitro Insulin Secretion and Viability

por Farmer, Kevin, Williams, S. Janette, Novikova, Lesya, Ramachandran, Karthik, Rawal, Sonia, Blagg, Brian S. J., Dobrowsky, Rick, Stehno-Bittel, Lisa
Publicado 2012

Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

por Ghosh, Suman, Shinogle, Heather E., Garg, Gaurav, Vielhauer, George A., Holzbeierlein, Jeffrey M., Dobrowsky, Rick T., Blagg, Brian S. J.
Publicado 2014

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

por Tomašič, Tihomir, Durcik, Martina, Keegan, Bradley M., Skledar, Darja Gramec, Zajec, Živa, Blagg, Brian S. J., Bryant, Sharon D.
Publicado 2020

Novel C‐terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self‐renewal, and epithelial–mesenchymal transition

por Subramanian, Chitra, Grogan, Patrick T., Wang, Ton, Bazzill, Joseph, Zuo, Ang, White, Peter T., Kalidindi, Avinaash, Kuszynski, Dawn, Wang, Grace, Blagg, Brian S. J., Cohen, Mark S.
Publicado 2020

Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice

por Urban, Michael J, Li, Chengyuan, Yu, Cuijuan, Lu, Yuanming, Krise, Joanna M, McIntosh, Michelle P, Rajewski, Roger A, Blagg, Brian S J, Dobrowsky, Rick T
Publicado 2010

Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

por Pal, Ranu, Hui, Dongwei, Menchen, Heather, Zhao, Huiping, Mozziconacci, Olivier, Wilkins, Heather, Blagg, Brian S. J., Schöneich, Christian, Swerdlow, Russell H., Michaelis, Mary L., Michaelis, Elias K.
Publicado 2023

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

por Pipalia, Nina H., Saad, Syed Z., Subramanian, Kanagaraj, Cross, Abigail, al-Motawa, Aisha, Garg, Kunal, Blagg, Brian S.J., Neckers, Len, Helquist, Paul, Wiest, Olaf, Ory, Daniel S., Maxfield, Frederick R.
Publicado 2021

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

por Khandelwal, Anuj, Kent, Caitlin N., Balch, Maurie, Peng, Shuxia, Mishra, Sanket J., Deng, Junpeng, Day, Victor W., Liu, Weiya, Subramanian, Chitra, Cohen, Mark, Holzbeierlein, Jeffery M., Matts, Robert, Blagg, Brian S. J.
Publicado 2018

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors

por Zhou, Jia, Gelot, Camille, Pantelidou, Constantia, Li, Adam, Yücel, Hatice, Davis, Rachel E., Farkkila, Anniina, Kochupurakkal, Bose, Syed, Aleem, Shapiro, Geoffrey I., Tainer, John A., Blagg, Brian S. J., Ceccaldi, Raphael, D’Andrea, Alan D.
Publicado 2021

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

por Stothert, Andrew R., Suntharalingam, Amirthaa, Tang, Xiaolan, Crowley, Vincent M., Mishra, Sanket J., Webster, Jack M., Nordhues, Bryce A., Huard, Dustin J. E., Passaglia, Christopher L., Lieberman, Raquel L., Blagg, Brian S. J., Blair, Laura J., Koren, John, Dickey, Chad A.
Publicado 2017

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

por Dunn, Diana M., Woodford, Mark R., Truman, Andrew W., Jensen, Sandra M., Schulman, Jacqualyn, Caza, Tiffany, Remillard, Taylor C., Loiselle, David, Wolfgeher, Donald, Blagg, Brian S.J., Franco, Lucas, Haystead, Timothy A., Daturpalli, Soumya, Mayer, Matthias P., Trepel, Jane B., Morgan, Rhodri M.L., Prodromou, Chrisostomos, Kron, Stephen J., Panaretou, Barry, Stetler-Stevenson, William G., Landas, Steve K., Neckers, Len, Bratslavsky, Gennady, Bourboulia, Dimitra, Mollapour, Mehdi
Publicado 2015