Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models

por Paragas, Jason, Blatt, Lawrence M., Hartmann, Chris, Huggins, John W., Endy, Tim P.
Publicado 2005

Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers

por Tong, Myron J, Blatt, Lawrence M, Kao, Jia-Horng, Cheng, Jason Tzuying, Corey, William G
Publicado 2007

Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells

por Kumaki, Yohichi, Day, Craig W., Wandersee, Miles K., Schow, Bradley P., Madsen, Justin S., Grant, Dixon, Roth, Jason P., Smee, Donald F., Blatt, Lawrence M., Barnard, Dale L.
Publicado 2008

Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules

por Kao, C. Cheng, Nie, Yuchun, Ren, Suping, De Costa, N. Tilani T.S., Pandey, Rajendra K., Hong, Jin, Smith, David B., Symons, Julian A., Beigelman, Leonid, Blatt, Lawrence M.
Publicado 2021

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

por Liu, Cheng, Boland, Sandro, Scholle, Michael D., Bardiot, Dorothee, Marchand, Arnaud, Chaltin, Patrick, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Gurard-Levin, Zachary A., Vandyck, Koen, Deval, Jerome
Publicado 2021

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

por Gurard-Levin, Zachary A., Liu, Cheng, Jekle, Andreas, Jaisinghani, Ruchika, Ren, Suping, Vandyck, Koen, Jochmans, Dirk, Leyssen, Pieter, Neyts, Johan, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Scholle, Michael D., Deval, Jerome
Publicado 2020

Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects

por McClure, Matthew W., Berliba, Elina, Tsertsvadze, Tengiz, Streinu-Cercel, Adrian, Vijgen, Leen, Astruc, Béatrice, Patat, Alain, Westland, Christopher, Chanda, Sushmita, Zhang, Qingling, Kakuda, Thomas N., Vuong, Jennifer, Khorlin, Nick, Beigelman, Leonid, Blatt, Lawrence M., Fry, John
Publicado 2018

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

por Luong, Xuan G., Stevens, Sarah K., Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M., Beigelman, Leonid N., Symons, Julian A., Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome
Publicado 2020

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

por Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K., Stoycheva, Antitsa, Rajwanshi, Vivek K., Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B., Blatt, Lawrence M., Symons, Julian A., Gonzalvez, Francois, Beigelman, Leonid
Publicado 2023

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

por Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan
Publicado 2021

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

por Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K., Fung, Amy, Stevens, Sarah K., Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D., Serebryany, Vladimir, Liu, Jyanwei, Smith, David B., Tam, Yuen, Zhang, Qingling, Moore, Martin L., Fearns, Rachel, Chanda, Sushmita M., Blatt, Lawrence M., Symons, Julian A., Beigelman, Leo
Publicado 2015

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

por Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K., De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen
Publicado 2023