The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models

por Bladt, Friedhelm, Friese-Hamim, Manja, Ihling, Christian, Wilm, Claudia, Blaukat, Andree
Publicado 2014

Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death

por Chiu, Li-Ya, Sun, Qing, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2023

DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia

por Carr, Michael I., Zimmermann, Astrid, Chiu, Li-Ya, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2020

Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors

por Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2023

Phosphorylation and regulation of a G protein–coupled receptor by protein kinase CK2

por Torrecilla, Ignacio, Spragg, Elizabeth J., Poulin, Benoit, McWilliams, Phillip J., Mistry, Sharad C., Blaukat, Andree, Tobin, Andrew B.
Publicado 2007

The Preclinical Pharmacology of Tepotinib—A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations

por Albers, Joachim, Friese-Hamim, Manja, Clark, Anderson, Schadt, Oliver, Walter-Bausch, Gina, Stroh, Christopher, Johne, Andreas, Karachaliou, Niki, Blaukat, Andree
Publicado 2023

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies

por Zimmermann, Astrid, Zenke, Frank T., Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T., Blaukat, Andree
Publicado 2022

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

por Haines, Eric, Nishida, Yuki, Carr, Michael I., Montoya, Rafael Heinz, Ostermann, Lauren B., Zhang, Weiguo, Zenke, Frank T., Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T.
Publicado 2021

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

por Klein, Carmen, Dokic, Ivana, Mairani, Andrea, Mein, Stewart, Brons, Stephan, Häring, Peter, Haberer, Thomas, Jäkel, Oliver, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree, Debus, Jürgen, Abdollahi, Amir
Publicado 2017

Deciphering MET‐dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics

por Bensimon, Ariel, Koch, Jonas P., Francica, Paola, Roth, Selina M., Riedo, Rahel, Glück, Astrid A., Orlando, Eleonora, Blaukat, Andree, Aebersold, Daniel M., Zimmer, Yitzhak, Aebersold, Ruedi, Medová, Michaela
Publicado 2020

DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy

por Carr, Michael I., Chiu, Li-Ya, Guo, Yige, Xu, Chunxiao, Lazorchak, Adam S., Yu, Huakui, Qin, Guozhong, Qi, Jin, Marelli, Bo, Lan, Yan, Sun, Qing, Czauderna, Frank, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2022

SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations

por Pudelko, Linda, Jaehrling, Frank, Reusch, Christof, Vitri, Sanziago, Stroh, Christopher, Linde, Nina, Sanderson, Michael P., Musch, Doreen, Lebrun, Catherine Jorand, Keil, Marina, Esdar, Christina, Blaukat, Andree, Rosell, Rafael, Schumacher, Karl Maria, Karachaliou, Niki
Publicado 2020

Nephrocystin-4 Regulates Pyk2-induced Tyrosine Phosphorylation of Nephrocystin-1 to Control Targeting to Monocilia

por Liebau, Max C., Höpker, Katja, Müller, Roman U., Schmedding, Ingolf, Zank, Sibylle, Schairer, Benjamin, Fabretti, Francesca, Höhne, Martin, Bartram, Malte P., Dafinger, Claudia, Hackl, Matthias, Burst, Volker, Habbig, Sandra, Zentgraf, Hanswalter, Blaukat, Andree, Walz, Gerd, Benzing, Thomas, Schermer, Bernhard
Publicado 2011

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

por Dale, Trevor, Clarke, Paul A., Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A., Wienke, Dirk, Blagg, Julian
Publicado 2015

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

por Clarke, Paul A, Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stephanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phillip, Hobbs, Stephen M, Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C, Eccles, Suzanne A, Hecht, Stefan, Urbahns, Klaus, Workman, Paul, Wienke, Dirk
Publicado 2016