The power of parent scientists

por Boehm, Jesse S.
Publicado 2021

The Cancer Dependency Map enables drug mechanism‐of‐action investigations

por Vazquez, Francisca, Boehm, Jesse S
Publicado 2020

LGG-59. Identifying hidden drivers of low-grade glioma tumor growth

por Misek, Sean, Fultineer, Aaron, Condurat, Alexandra, Zhou, Kevin, Root, David, Persky, Nicole, Boehm, Jesse, Bandopadhayay, Pratiti, Beroukhim, Rameen
Publicado 2022

Global computational alignment of tumor and cell line transcriptional profiles

por Warren, Allison, Chen, Yejia, Jones, Andrew, Shibue, Tsukasa, Hahn, William C., Boehm, Jesse S., Vazquez, Francisca, Tsherniak, Aviad, McFarland, James M.
Publicado 2021

Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

por Dempster, Joshua M., Boyle, Isabella, Vazquez, Francisca, Root, David E., Boehm, Jesse S., Hahn, William C., Tsherniak, Aviad, McFarland, James M.
Publicado 2021

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

por Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Publicado 2015

Systematic morphological profiling of human gene and allele function via Cell Painting

por Rohban, Mohammad Hossein, Singh, Shantanu, Wu, Xiaoyun, Berthet, Julia B, Bray, Mark-Anthony, Shrestha, Yashaswi, Varelas, Xaralabos, Boehm, Jesse S, Carpenter, Anne E
Publicado 2017

Sparse dictionary learning recovers pleiotropy from human cell fitness screens

por Pan, Joshua, Kwon, Jason J., Talamas, Jessica A., Borah, Ashir A., Vazquez, Francisca, Boehm, Jesse S., Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M., Hahn, William C.
Publicado 2022

Patient-derived xenografts undergo murine-specific tumor evolution

por Ben-David, Uri, Ha, Gavin, Tseng, Yuen-Yi, Greenwald, Noah F., Oh, Coyin, Shih, Juliann, McFarland, James M., Wong, Bang, Boehm, Jesse S., Beroukhim, Rameen, Golub, Todd R.
Publicado 2017

Cell Painting predicts impact of lung cancer variants

por Caicedo, Juan C., Arevalo, John, Piccioni, Federica, Bray, Mark-Anthony, Hartland, Cathy L., Wu, Xiaoyun, Brooks, Angela N., Berger, Alice H., Boehm, Jesse S., Carpenter, Anne E., Singh, Shantanu
Publicado 2022

PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling

por Moody, Susan E., Schinzel, Anna C., Singh, Shambhavi, Izzo, Francesca, Strickland, Matthew R., Luo, Leo, Thomas, Sapana R., Boehm, Jesse S., Kim, So Young, Wang, Zhigang C., Hahn, William C.
Publicado 2014

Weekly SARS-CoV-2 screening of asymptomatic kindergarten to grade 12 students and staff helps inform strategies for safer in-person learning

por Doron, Shira, Ingalls, Robin R., Beauchamp, Anne, Boehm, Jesse S., Boucher, Helen W., Chow, Linda H., Corridan, Linda, Goehringer, Katey, Golenbock, Doug, Larsen, Liz, Lussier, David, Testa, Marcia, Ciaranello, Andrea
Publicado 2021

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

por Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad
Publicado 2023

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

por Kim, So Young, Dunn, Ian F., Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C., Wittner, Ben, Silver, Serena J., Root, David E., Boehm, Jesse S., Ramaswamy, Sridhar, Lander, Eric S., Hahn, William C.
Publicado 2010

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

por Shrestha, Yashaswi, Schafer, Eric J., Boehm, Jesse S., Thomas, Sapana R., He, Frank, Du, Jinyan, Wang, Shumei, Barretina, Jordi, Weir, Barbara A., Zhao, Jean J., Polyak, Kornelia, Golub, Todd R., Beroukhim, Rameen, Hahn, William C.
Publicado 2011

NetSig: network-based discovery from cancer genomes

por Horn, Heiko, Lawrence, Michael S., Chouinard, Candace R., Shrestha, Yashaswi, Hu, Jessica Xin, Worstell, Elizabeth, Shea, Emily, Ilic, Nina, Kim, Eejung, Kamburov, Atanas, Kashani, Alireza, Hahn, William C., Campbell, Joshua D., Boehm, Jesse S., Getz, Gad, Lage, Kasper
Publicado 2017

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

por McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad
Publicado 2018

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

por Giannikou, Krinio, Malinowska, Izabela A., Pugh, Trevor J., Yan, Rachel, Tseng, Yuen-Yi, Oh, Coyin, Kim, Jaegil, Tyburczy, Magdalena E., Chekaluk, Yvonne, Liu, Yang, Alesi, Nicola, Finlay, Geraldine A., Wu, Chin-Lee, Signoretti, Sabina, Meyerson, Matthew, Getz, Gad, Boehm, Jesse S., Henske, Elizabeth P., Kwiatkowski, David J.
Publicado 2016

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

por Collins, Natalie B, Al Abosy, Rose, Miller, Brian C, Bi, Kevin, Zhao, Qihong, Quigley, Michael, Ishizuka, Jeffrey J, Yates, Kathleen B, Pope, Hans W, Manguso, Robert T, Shrestha, Yashaswi, Wadsworth, Marc, Hughes, Travis, Shalek, Alex K, Boehm, Jesse S, Hahn, William C, Doench, John G, Haining, W Nicholas
Publicado 2022

GeNets: A unified web platform for network-based analyses of genomic data

por Li, Taibo, Kim, April, Rosenbluh, Joseph, Horn, Heiko, Greenfeld, Liraz, An, David, Zimmer, Andrew, Liberzon, Arthur, Bistline, Jon, Natoli, Ted, Li, Yang, Tsherniak, Aviad, Narayan, Rajiv, Subramanian, Aravind, Liefeld, Ted, Wong, Bang, Thompson, Dawn, Calvo, Sarah, Carr, Steve, Boehm, Jesse, Jaffe, Jake, Mesirov, Jill, Hacohen, Nir, Regev, Aviv, Lage, Kasper
Publicado 2018