IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

por Ikink, Gerjon J., Boer, Mandy, Bakker, Elvira R. M., Hilkens, John
Publicado 2016

R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer

por ter Steege, Eline J, Boer, Mandy, Timmer, Nikki C, Ammerlaan, Carola ME, Song, Ji‐Ying, Derksen, Patrick WB, Hilkens, John, Bakker, Elvira RM
Publicado 2022

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance

por Ikink, Gerjon J., Boer, Mandy, Bakker, Elvira R. M., Vendel-Zwaagstra, Annabel, Klijn, Chris, ten Hoeve, Jelle, Jonkers, Jos, Wessels, Lodewyk F., Hilkens, John
Publicado 2018

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis

por Hilkens, John, Timmer, Nikki C, Boer, Mandy, Ikink, Gerjon J, Schewe, Matthias, Sacchetti, Andrea, Koppens, Martijn A J, Song, Ji-Ying, Bakker, Elvira R M
Publicado 2017

Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors

por Klijn, Christiaan, Koudijs, Marco J., Kool, Jaap, ten Hoeve, Jelle, Boer, Mandy, de Moes, Joost, Akhtar, Waseem, van Miltenburg, Martine, Vendel-Zwaagstra, Annabel, Reinders, Marcel J. T., Adams, David J., van Lohuizen, Maarten, Hilkens, John, Wessels, Lodewyk F. A., Jonkers, Jos
Publicado 2013