Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor

por Willems, Henriëtte M. G., Edwards, Simon, Boffey, Helen K., Chawner, Stephen J., Green, Christopher, Romero, Tamara, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2023

The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

por Aldred, Gregory G., Rooney, Timothy P. C., Willems, Henriette M. G., Boffey, Helen K., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2023

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules

por Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2022

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode

por Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2022