Computational pharmacokinetics at a crossroads

por Bois, Frédéric Y
Publicado 2013

A Mechanistic Modeling Framework for Predicting Metabolic Interactions in Complex Mixtures

por Cheng, Shu, Bois, Frederic Y.
Publicado 2011

A Computational Model to Predict Rat Ovarian Steroid Secretion from In Vitro Experiments with Endocrine Disruptors

por Quignot, Nadia, Bois, Frédéric Y.
Publicado 2013

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

por Rostami‐Hodjegan, Amin, Bois, Frederic Y.
Publicado 2021

Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells

por Hamon, Jérémy, Jennings, Paul, Bois, Frederic Y
Publicado 2014

Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions

por Cheng, Shu, Prot, Jean-Matthieu, Leclerc, Eric, Bois, Frédéric Y
Publicado 2012

Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling

por Hsieh, Nan-Hung, Reisfeld, Brad, Bois, Frederic Y., Chiu, Weihsueh A.
Publicado 2018

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

por Liu, Dan, Li, Linzhong, Rostami-Hodjegan, Amin, Bois, Frederic Y., Jamei, Masoud
Publicado 2020

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling

por Han, Chunyan, Sun, Tiancheng, Chirumamilla, Siri Kalyan, Bois, Frederic Y., Xu, Mandy, Rostami-Hodjegan, Amin
Publicado 2023

Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals

por Zeise, Lauren, Bois, Frederic Y., Chiu, Weihsueh A., Hattis, Dale, Rusyn, Ivan, Guyton, Kathryn Z.
Publicado 2012

High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors

por Bois, Frederic Y., Golbamaki-Bakhtyari, Nazanin, Kovarich, Simona, Tebby, Cleo, Gabb, Henry A., Lemazurier, Emmanuel
Publicado 2017

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp(®) simulator

por Khalidi, Hiba, Onasanwo, Anthonia, Islam, Barira, Jo, Heeseung, Fisher, Ciarán, Aidley, Rich, Gardner, Iain, Bois, Frederic Y.
Publicado 2022

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

por Zgheib, Elias, Limonciel, Alice, Jiang, Xiaoqi, Wilmes, Anja, Wink, Steven, van de Water, Bob, Kopp-Schneider, Annette, Bois, Frederic Y., Jennings, Paul
Publicado 2018

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

por Zgheib, Elias, Limonciel, Alice, Jiang, Xiaoqi, Wilmes, Anja, Wink, Steven, van de Water, Bob, Kopp-Schneider, Annette, Bois, Frederic Y., Jennings, Paul
Publicado 2019

Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers

por Wedagedera, Janak R., Afuape, Anthonia, Chirumamilla, Siri Kalyan, Momiji, Hiroshi, Leary, Robert, Dunlavey, Mike, Matthews, Richard, Abduljalil, Khaled, Jamei, Masoud, Bois, Frederic Y.
Publicado 2022

Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods

por Berggren, Elisabet, White, Andrew, Ouedraogo, Gladys, Paini, Alicia, Richarz, Andrea-Nicole, Bois, Frederic Y., Exner, Thomas, Leite, Sofia, Grunsven, Leo A. van, Worth, Andrew, Mahony, Catherine
Publicado 2017

Advancing human health risk assessment

por Lanzoni, Anna, Castoldi, Anna F, Kass, George EN, Terron, Andrea, De Seze, Guilhem, Bal‐Price, Anna, Bois, Frédéric Y, Delclos, K Barry, Doerge, Daniel R, Fritsche, Ellen, Halldorsson, Thorhallur, Kolossa‐Gehring, Marike, Hougaard Bennekou, Susanne, Koning, Frits, Lampen, Alfonso, Leist, Marcel, Mantus, Ellen, Rousselle, Christophe, Siegrist, Michael, Steinberg, Pablo, Tritscher, Angelika, Van de Water, Bob, Vineis, Paolo, Walker, Nigel, Wallace, Heather, Whelan, Maurice, Younes, Maged
Publicado 2019

Application of Evidence-Based Methods to Construct Mechanism-Driven Chemical Assessment Frameworks

por Hoffmann, Sebastian, Aiassa, Elisa, Angrish, Michelle, Beausoleil, Claire, Bois, Frederic Y., Ciccolallo, Laura, Craig, Peter S., de Vries, Rob B. M., Dorne, Jean Lou C. M., Druwe, Ingrid L., Edwards, Stephen W., Eskes, Chantra, Georgiadis, Marios, Hartung, Thomas, Kienzler, Aude, Kristjansson, Elisabeth A., Lam, Juleen, Martino, Laura, Meek, Bette, Morgan, Rebecca L., Munoz-Guajardo, Irene, Noyes, Pamela D., Parmelli, Elena, Piersma, Aldert, Rooney, Andrew, Sena, Emily, Sullivan, Kristie, Tarazona, José, Terron, Andrea, Thayer, Kris, Turner, Jan, Verbeek, Jos, Verloo, Didier, Vinken, Mathieu, Watford, Sean, Whaley, Paul, Wikoff, Daniele, Willett, Kate, Tsaioun, Katya
Publicado 2022

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

por Cote, Ila, Andersen, Melvin E., Ankley, Gerald T., Barone, Stanley, Birnbaum, Linda S., Boekelheide, Kim, Bois, Frederic Y., Burgoon, Lyle D., Chiu, Weihsueh A., Crawford-Brown, Douglas, Crofton, Kevin M., DeVito, Michael, Devlin, Robert B., Edwards, Stephen W., Guyton, Kathryn Z., Hattis, Dale, Judson, Richard S., Knight, Derek, Krewski, Daniel, Lambert, Jason, Maull, Elizabeth Anne, Mendrick, Donna, Paoli, Gregory M., Patel, Chirag Jagdish, Perkins, Edward J., Poje, Gerald, Portier, Christopher J., Rusyn, Ivan, Schulte, Paul A., Simeonov, Anton, Smith, Martyn T., Thayer, Kristina A., Thomas, Russell S., Thomas, Reuben, Tice, Raymond R., Vandenberg, John J., Villeneuve, Daniel L., Wesselkamper, Scott, Whelan, Maurice, Whittaker, Christine, White, Ronald, Xia, Menghang, Yauk, Carole, Zeise, Lauren, Zhao, Jay, DeWoskin, Robert S.
Publicado 2016