Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

por Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Publicado 2014

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics

por Orris, Benjamin, Huynh, Kevin W, Ammirati, Mark, Han, Seungil, Bolaños, Ben, Carmody, Jason, Petroski, Matthew D, Bosbach, Benedikt, Shields, David J, Stivers, James T
Publicado 2022

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

por Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.
Publicado 2022

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

por Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Publicado 2017

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

por Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Publicado 2016

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

por Ryan, Kevin, Bolaňos, Ben, Smith, Marissa, Palde, Prakash B., Cuenca, Paulina Delgado, VanArsdale, Todd L., Niessen, Sherry, Zhang, Lianglin, Behenna, Douglas, Ornelas, Martha A., Tran, Khanh T., Kaiser, Stephen, Lum, Lawrence, Stewart, Al, Gajiwala, Ketan S.
Publicado 2021