Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases

por Aulić, Suzana, Bolognesi, Maria Laura, Legname, Giuseppe
Publicado 2013

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease

por Prati, Federica, Cavalli, Andrea, Bolognesi, Maria Laura
Publicado 2016

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

por Alcaro, Stefano, Bolognesi, Maria Laura, García-Sosa, Alfonso T., Rapposelli, Simona
Publicado 2019

A perspective on multi-target drug discovery and design for complex diseases

por Ramsay, Rona R., Popovic-Nikolic, Marija R., Nikolic, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura
Publicado 2018

Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters

por Prati, Federica, Goldman-Pinkovich, Adele, Lizzi, Federica, Belluti, Federica, Koren, Roni, Zilberstein, Dan, Bolognesi, Maria Laura
Publicado 2014

Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery

por Espinoza-Chávez, Rocío Marisol, Salerno, Alessandra, Liuzzi, Anastasia, Ilari, Andrea, Milelli, Andrea, Uliassi, Elisa, Bolognesi, Maria Laura
Publicado 2022

From Combinations to Single-Molecule Polypharmacology—Cromolyn-Ibuprofen Conjugates for Alzheimer’s Disease

por Albertini, Claudia, Naldi, Marina, Petralla, Sabrina, Strocchi, Silvia, Grifoni, Daniela, Monti, Barbara, Bartolini, Manuela, Bolognesi, Maria Laura
Publicado 2021

Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease

por Uliassi, Elisa, de Oliveira, Andressa Souza, de Camargo Nascente, Luciana, Romeiro, Luiz Antonio Soares, Bolognesi, Maria Laura
Publicado 2021

Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One

por Salerno, Alessandra, Seghetti, Francesca, Caciolla, Jessica, Uliassi, Elisa, Testi, Eleonora, Guardigni, Melissa, Roberti, Marinella, Milelli, Andrea, Bolognesi, Maria Laura
Publicado 2022

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

por Capurro, Valeria, Busquet, Perrine, Lopes, Joao Pedro, Bertorelli, Rosalia, Tarozzo, Glauco, Bolognesi, Maria Laura, Piomelli, Daniele, Reggiani, Angelo, Cavalli, Andrea
Publicado 2013

α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis

por Rossi, Michele, Petralla, Sabrina, Protti, Michele, Baiula, Monica, Kobrlova, Tereza, Soukup, Ondrej, Spampinato, Santi Mario, Mercolini, Laura, Monti, Barbara, Bolognesi, Maria Laura
Publicado 2020

The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

por Bianco, Maria da Conceição Avelino Dias, Inacio Leite, Debora, Silva Castelo Branco, Frederico, Boechat, Nubia, Uliassi, Elisa, Bolognesi, Maria Laura, Bastos, Monica Macedo
Publicado 2022

Repurposing of Drugs Targeting YAP-TEAD Functions

por Elisi, Gian Marco, Santucci, Matteo, D’Arca, Domenico, Lauriola, Angela, Marverti, Gaetano, Losi, Lorena, Scalvini, Laura, Bolognesi, Maria Laura, Mor, Marco, Costi, Maria Paola
Publicado 2018

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

por Lauriola, Angela, Uliassi, Elisa, Santucci, Matteo, Bolognesi, Maria Laura, Mor, Marco, Scalvini, Laura, Elisi, Gian Marco, Gozzi, Gaia, Tagliazucchi, Lorenzo, Marverti, Gaetano, Ferrari, Stefania, Losi, Lorena, D’Arca, Domenico, Costi, Maria Paola
Publicado 2022

PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease

por Guardigni, Melissa, Pruccoli, Letizia, Santini, Alan, Simone, Angela De, Bersani, Matteo, Spyrakis, Francesca, Frabetti, Flavia, Uliassi, Elisa, Andrisano, Vincenza, Pagliarani, Barbara, Fernández-Gómez, Paula, Palomo, Valle, Bolognesi, Maria Laura, Tarozzi, Andrea, Milelli, Andrea
Publicado 2023

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance

por Colini Baldeschi, Arianna, Zattoni, Marco, Vanni, Silvia, Nikolic, Lea, Ferracin, Chiara, La Sala, Giuseppina, Summa, Maria, Bertorelli, Rosalia, Bertozzi, Sine Mandrup, Giachin, Gabriele, Carloni, Paolo, Bolognesi, Maria Laura, De Vivo, Marco, Legname, Giuseppe
Publicado 2022

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

por Gandini, Annachiara, Gonçalves, Ana Elisa, Strocchi, Silvia, Albertini, Claudia, Janočková, Jana, Tramarin, Anna, Grifoni, Daniela, Poeta, Eleonora, Soukup, Ondrej, Muñoz-Torrero, Diego, Monti, Barbara, Sabaté, Raimon, Bartolini, Manuela, Legname, Giuseppe, Bolognesi, Maria Laura
Publicado 2022

Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

por Pieretti, Simone, Haanstra, Jurgen R., Mazet, Muriel, Perozzo, Remo, Bergamini, Christian, Prati, Federica, Fato, Romana, Lenaz, Giorgio, Capranico, Giovanni, Brun, Reto, Bakker, Barbara M., Michels, Paul A. M., Scapozza, Leonardo, Bolognesi, Maria Laura, Cavalli, Andrea
Publicado 2013

Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei...

por Cerone, Michela, Uliassi, Elisa, Prati, Federica, Ebiloma, Godwin U., Lemgruber, Leandro, Bergamini, Christian, Watson, David G., de A. M. Ferreira, Thais, Roth Cardoso, Gabriella Simões Heyn, Soares Romeiro, Luiz A., de Koning, Harry P., Bolognesi, Maria Laura
Publicado 2019

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors

por González-González, Alonzo, Sánchez-Sánchez, Oscar, Krauth-Siegel, R. Luise, Bolognesi, Maria Laura, Gớmez-Escobedo, Rogelio, Nogueda-Torres, Benjamín, Vázquez-Jiménez, Lenci K., Saavedra, Emma, Encalada, Rusely, Espinoza-Hicks, José Carlos, Paz-González, Alma D., Rivera, Gildardo
Publicado 2022