Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity

por Klein, Victoria G., Bond, Adam G., Craigon, Conner, Lokey, R. Scott, Ciulli, Alessio
Publicado 2021

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

por Bond, Adam G., Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J. Julian, Alessi, Dario R., Ciulli, Alessio
Publicado 2021

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabiliz...

por Vu, Lan Phuong, Diehl, Claudia J., Casement, Ryan, Bond, Adam G., Steinebach, Christian, Strašek, Nika, Bricelj, Aleša, Perdih, Andrej, Schnakenburg, Gregor, Sosič, Izidor, Ciulli, Alessio, Gütschow, Michael
Publicado 2023

Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

por Pietrobono, Silvia, Gaudio, Eugenio, Gagliardi, Sinforosa, Zitani, Mariapaola, Carrassa, Laura, Migliorini, Francesca, Petricci, Elena, Manetti, Fabrizio, Makukhin, Nikolai, Bond, Adam G., Paradise, Brooke D., Ciulli, Alessio, Fernandez-Zapico, Martin E., Bertoni, Francesco, Stecca, Barbara
Publicado 2021