68722 Role of ER calcium in beta cell senescence and diabetes pathophysiology

por Weaver, Staci A., Kono, Tatsuyoshi, Syed, Farooq, Bone, Robert, Evans-Molina, Carmella
Publicado 2021

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

por Bailey, Charlotte S.L., Bone, Robert A., Murray, Philip J., Dale, J. Kim
Publicado 2017

The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites

por Tenin, Gennady, Wright, David, Ferjentsik, Zoltan, Bone, Robert, McGrew, Michael J, Maroto, Miguel
Publicado 2010

Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

por Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N., Mobley, James A., Hancock, William, Ramanadham, Sasanka
Publicado 2013

A balance of positive and negative regulators determines the pace of the segmentation clock

por Wiedermann, Guy, Bone, Robert Alexander, Silva, Joana Clara, Bjorklund, Mia, Murray, Philip J, Dale, J Kim
Publicado 2015

Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

por Martin Gonzalez, Javier, Morgani, Sophie M., Bone, Robert A., Bonderup, Kasper, Abelchian, Sahar, Brakebusch, Cord, Brickman, Joshua M.
Publicado 2016

Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin

por Zhang, Yanqing, Zhang, Yuan, Bone, Robert N., Cui, Wanxing, Peng, Ji-Bin, Siegal, Gene P., Wang, Hongjun, Wu, Hongju
Publicado 2012

Offspring of Obese Dams Exhibit Sex-Differences in Pancreatic Heparan Sulfate Glycosaminoglycans and Islet Insulin Secretion

por Casasnovas, Jose, Damron, Christopher Luke, Jarrell, James, Orr, Kara S., Bone, Robert N., Archer-Hartmann, Stephanie, Azadi, Parastoo, Kua, Kok Lim
Publicado 2021

Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy

por Lei, Xiaoyong, Bone, Robert N., Ali, Tomader, Wohltmann, Mary, Gai, Ying, Goodwin, Karen J., Bohrer, Alan E., Turk, John, Ramanadham, Sasanka
Publicado 2013

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM

por Bone, Robert A., Bailey, Charlotte S. L., Wiedermann, Guy, Ferjentsik, Zoltan, Appleton, Paul L., Murray, Philip J., Maroto, Miguel, Dale, J. Kim
Publicado 2014

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

por Bone, Robert N., Gai, Ying, Magrioti, Victoria, Kokotou, Maroula G., Ali, Tomader, Lei, Xiaoyong, Tse, Hubert M., Kokotos, George, Ramanadham, Sasanka
Publicado 2015

Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivo

por Bone, Robert N., Icyuz, Mert, Zhang, Yanqing, Zhang, Yuan, Cui, Wanxing, Wang, Hongjun, Peng, Ji-Bin, Matthews, Qiana L., Siegal, Gene P., Wu, Hongju
Publicado 2012

Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation

por Tong, Xin, Chaudhry, Zunaira, Lee, Chih-Chun, Bone, Robert N., Kanojia, Sukrati, Maddatu, Judith, Sohn, Paul, Weaver, Staci A., Robertson, Morgan A., Petrache, Irina, Evans-Molina, Carmella, Kono, Tatsuyoshi
Publicado 2020

A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

por Syed, Farooq, Singhal, Divya, Raedschelders, Koen, Krishnan, Preethi, Bone, Robert N., McLaughlin, Madeline R., Van Eyk, Jennifer E., Mirmira, Raghavendra G., Yang, Mei-Ling, Mamula, Mark J., Wu, Huanmei, Liu, Xiaowen, Evans-Molina, Carmella
Publicado 2022

SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells

por Iida, Hitoshi, Kono, Tatsuyoshi, Lee, Chih-Chun, Krishnan, Preethi, Arvin, Matthew C., Weaver, Staci A., Jarvela, Timothy S., Branco, Renato C. S., McLaughlin, Madeline R., Bone, Robert N., Tong, Xin, Arvan, Peter, Lindberg, Iris, Evans-Molina, Carmella
Publicado 2023

Lipid mediators and biomarkers associated with type 1 diabetes development

por Nelson, Alexander J., Stephenson, Daniel J., Bone, Robert N., Cardona, Christopher L., Park, Margaret A., Tusing, Ying G., Lei, Xiaoyong, Kokotos, George, Graves, Christina L., Mathews, Clayton E., Kramer, Joanna, Hessner, Martin J., Chalfant, Charles E., Ramanadham, Sasanka
Publicado 2020

A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues

por Reilly, Austin M., Yan, Shijun, Huang, Menghao, Abhyankar, Surabhi D., Conley, Jason M., Bone, Robert N., Stull, Natalie D., Horan, Daniel J., Roh, Hyun C., Robling, Alexander G., Ericsson, Aaron C., Dong, Xiaocheng C., Evans-Molina, Carmella, Ren, Hongxia
Publicado 2021