CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques

por Wang, Lan, Suryawanshi, Gajendra W., Kim, Shihyoung, Guan, Xin, Bonifacino, Aylin C., Metzger, Mark E., Donahue, Robert E., Kim, Sanggu, Chen, Irvin S.Y.
Publicado 2023

Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

por Uchida, Naoya, Weitzel, R Patrick, Shvygin, Anna, Skala, Luke P, Raines, Lydia, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Donahue, Robert E, Tisdale, John F
Publicado 2016

Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders

por Uchida, Naoya, Hsieh, Matthew M., Raines, Lydia, Haro-Mora, Juan J., Demirci, Selami, Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Donahue, Robert E., Tisdale, John F.
Publicado 2019

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number

por Uchida, Naoya, Evans, Molly E, Hsieh, Matthew M, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Sellers, Stephanie E, Dunbar, Cynthia E, Donahue, Robert E, Tisdale, John F
Publicado 2013

Clonal tracking of erythropoiesis in rhesus macaques

por Fan, Xing, Wu, Chuanfeng, Truitt, Lauren L., Espinoza, Diego A., Sellers, Stephanie, Bonifacino, Aylin, Zhou, Yifan, Cordes, Stefan F., Krouse, Allen, Metzger, Mark, Donahue, Robert E., Lu, Rong, Dunbar, Cynthia E.
Publicado 2020

Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques

por Abraham, Diana M., Lozano, Richard J., Guitart, Xavi, Liang, Jialiu A., Mortlock, Ryland D., Espinoza, Diego A., Fan, Xing, Krouse, Allen, Bonifacino, Aylin, Hong, So Gun, Singh, Komudi, Tisdale, John F., Wu, Chuanfeng, Dunbar, Cynthia E.
Publicado 2022

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity

por Yabe, Idalia M., Truitt, Lauren L., Espinoza, Diego A., Wu, Chuanfeng, Koelle, Samson, Panch, Sandhya, Corat, Marcus A.F., Winkler, Thomas, Yu, Kyung-Rok, Hong, So Gun, Bonifacino, Aylin, Krouse, Allen, Metzger, Mark, Donahue, Robert E., Dunbar, Cynthia E.
Publicado 2018

Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

por Srivastava, Sandeep K., Truitt, Lauren L., Wu, Chuanfeng, Glaser, Adam, Nolan, Daniel J., Ginsberg, Michael, Espinoza, Diego A., Koelle, Samson, Yabe, Idalia M., Yu, Kyung-Rok, Hong, Sogun, Sellers, Stephanie, Krouse, Allen, Bonifacino, Aylin, Metzger, Mark, Dagur, Pradeep K., Donahue, Robert E., Dunbar, Cynthia E., Panch, Sandhya R.
Publicado 2021

Preclinical evaluation for engraftment of CD34(+) cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models

por Uchida, Naoya, Li, Linhong, Nassehi, Tina, Drysdale, Claire M., Yapundich, Morgan, Gamer, Jackson, Haro-Mora, Juan J., Demirci, Selami, Leonard, Alexis, Bonifacino, Aylin C., Krouse, Allen E., Linde, N. Seth, Allen, Cornell, Peshwa, Madhusudan V., De Ravin, Suk See, Donahue, Robert E., Malech, Harry L., Tisdale, John F.
Publicado 2021

Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation

por Essawi, Khaled, Hakami, Waleed, Naeem Khan, Muhammad Behroz, Martin, Reid, Zeng, Jing, Chu, Rebecca, Uchida, Naoya, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Blobel, Gerd A., Gerdemann, Ulrike, Kean, Leslie S., Maitland, Stacy A., Wolfe, Scot A., Metais, Jean-Yves, Gottschalk, Stephen, Bauer, Daniel E., Tisdale, John F., Demirci, Selami
Publicado 2023

Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model

por Uchida, Naoya, Stasula, Ulana, Demirci, Selami, Germino-Watnick, Paula, Hinds, Malikiya, Le, Anh, Chu, Rebecca, Berg, Alexander, Liu, Xiong, Su, Ling, Wu, Xiaolin, Krouse, Allen E., Linde, N. Seth, Bonifacino, Aylin, Hong, So Gun, Dunbar, Cynthia E., Lanieri, Leanne, Bhat, Anjali, Palchaudhuri, Rahul, Bennet, Bindu, Hoban, Megan, Bertelsen, Kirk, Olson, Lisa M., Donahue, Robert E., Tisdale, John F.
Publicado 2023

Forced enhancer-promoter rewiring to alter gene expression in animal models

por Peslak, Scott A., Demirci, Selami, Chandra, Vemika, Ryu, Byoung, Bhardwaj, Saurabh K., Jiang, Jing, Rupon, Jeremy W., Throm, Robert E., Uchida, Naoya, Leonard, Alexis, Essawi, Khaled, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Ferrara, Francesca, Wielgosz, Matthew, Abdulmalik, Osheiza, Hamagami, Nicole, Germino-Watnick, Paula, Le, Anh, Chu, Rebecca, Hinds, Malikiya, Weiss, Mitchell J., Tong, Wei, Tisdale, John F., Blobel, Gerd A.
Publicado 2023