Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

por Adhikari, Pramisha, Xie, Bing, Semeano, Ana, Bonifazi, Alessandro, Battiti, Francisco O., Newman, Amy H., Yano, Hideaki, Shi, Lei
Publicado 2021

Novel and Potent Dopamine D(2) Receptor Go-Protein Biased Agonists

por Bonifazi, Alessandro, Yano, Hideaki, Guerrero, Adrian M., Kumar, Vivek, Hoffman, Alexander F., Lupica, Carl R., Shi, Lei, Newman, Amy Hauck
Publicado 2019

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D(3) Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders

por Bonifazi, Alessandro, Newman, Amy H., Keck, Thomas M., Gervasoni, Silvia, Vistoli, Giulio, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Quaglia, Wilma, Piergentili, Alessandro
Publicado 2021

Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus

por Del Bello, Fabio, Bonifazi, Alessandro, Giorgioni, Gianfabio, Piergentili, Alessandro, Sabbieti, Maria Giovanna, Agas, Dimitrios, Dell’Aera, Marzia, Matucci, Rosanna, Górecki, Marcin, Pescitelli, Gennaro, Vistoli, Giulio, Quaglia, Wilma
Publicado 2020

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

por Bhat, Shreyas, Guthrie, Daryl A., Kasture, Ameya, El-Kasaby, Ali, Cao, Jianjing, Bonifazi, Alessandro, Ku, Therese, Giancola, JoLynn B., Hummel, Thomas, Freissmuth, Michael, Newman, Amy Hauck
Publicado 2020

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

por Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Publicado 2020

Highly Potent and Selective Dopamine D(4) Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma

por Pavletić, Pegi, Semeano, Ana, Yano, Hideaki, Bonifazi, Alessandro, Giorgioni, Gianfabio, Piergentili, Alessandro, Quaglia, Wilma, Sabbieti, Maria Giovanna, Agas, Dimitrios, Santoni, Giorgio, Pallini, Roberto, Ricci-Vitiani, Lucia, Sabato, Emanuela, Vistoli, Giulio, Del Bello, Fabio
Publicado 2022

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

por Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Publicado 2016

Cross-talk between alpha(1D)-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation

por Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Liberati, Sonia, Cardinali, Claudio, Farfariello, Valerio, Tomassoni, Daniele, Quaglia, Wilma, Piergentili, Alessandro, Bonifazi, Alessandro, Del Bello, Fabio, Santoni, Matteo, Mammana, Gabriele, Servi, Lucilla, Filosa, Alessandra, Gismondi, Angela, Santoni, Giorgio
Publicado 2014

Dopamine D(4) Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

por Keck, Thomas M., Free, R. Benjamin, Day, Marilyn M., Brown, Sonvia L., Maddaluna, Michele S., Fountain, Griffin, Cooper, Charles, Fallon, Brooke, Holmes, Matthew, Stang, Christopher T., Burkhardt, Russell, Bonifazi, Alessandro, Ellenberger, Michael P., Newman, Amy H., Sibley, David R., Wu, Chun, Boateng, Comfort A.
Publicado 2019

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

por Boateng, Comfort A., Nilson, Ashley N., Placide, Rebekah, Pham, Mimi L., Jakobs, Franziska M., Boldizsar, Noelia, McIntosh, Scot, Stallings, Leia S., Korankyi, Ivana V., Kelshikar, Shreya, Shah, Nisha, Panasis, Diandra, Muccilli, Abigail, Ladik, Maria, Maslonka, Brianna, McBride, Connor, Sanchez, Moises Ximello, Akca, Ebrar, Alkhatib, Mohammad, Saez, Julianna, Nguyen, Catherine, Kurtyan, Emily, DePierro, Jacquelyn, Crowthers, Raymond, Brunt, Dylan, Bonifazi, Alessandro, Newman, Amy Hauck, Rais, Rana, Slusher, Barbara S., Free, R. Benjamin, Sibley, David R., Stewart, Kent D., Wu, Chun, Hemby, Scott E., Keck, Thomas M.
Publicado 2023