Use of microarray hybrid capture and next-generation sequencing to identify the anatomy of a transgene

por DuBose, Amanda J., Lichtenstein, Stephen T., Narisu, Narisu, Bonnycastle, Lori L., Swift, Amy J., Chines, Peter S., Collins, Francis S.
Publicado 2013

Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

por Stančáková, Alena, Kuulasmaa, Teemu, Paananen, Jussi, Jackson, Anne U., Bonnycastle, Lori L., Collins, Francis S., Boehnke, Michael, Kuusisto, Johanna, Laakso, Markku
Publicado 2009

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours

por Grenko, Caleb M., Bonnycastle, Lori L., Taylor, Henry J., Yan, Tingfen, Swift, Amy J., Robertson, Catherine C., Narisu, Narisu, Erdos, Michael R., Collins, Francis S., Taylor, D. Leland
Publicado 2023

Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men

por Stančáková, Alena, Paananen, Jussi, Soininen, Pasi, Kangas, Antti J., Bonnycastle, Lori L., Morken, Mario A., Collins, Francis S., Jackson, Anne U., Boehnke, Michael L., Kuusisto, Johanna, Ala-Korpela, Mika, Laakso, Markku
Publicado 2011

Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis

por Taylor, Henry J., Hung, Yu-Han, Narisu, Narisu, Erdos, Michael R., Kanke, Matthew, Yan, Tingfen, Grenko, Caleb M., Swift, Amy J., Bonnycastle, Lori L., Sethupathy, Praveen, Collins, Francis S., Taylor, D. Leland
Publicado 2023

Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose

por Li, Xia, Shu, Yu-Hsiang, Xiang, Anny H., Trigo, Enrique, Kuusisto, Johanna, Hartiala, Jaana, Swift, Amy J., Kawakubo, Miwa, Stringham, Heather M., Bonnycastle, Lori L., Lawrence, Jean M., Laakso, Markku, Allayee, Hooman, Buchanan, Thomas A., Watanabe, Richard M.
Publicado 2009

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits

por Hudaiberdiev, Sanjarbek, Taylor, D. Leland, Song, Wei, Narisu, Narisu, Bhuiyan, Redwan M., Taylor, Henry J., Tang, Xuming, Yan, Tingfen, Swift, Amy J., Bonnycastle, Lori L., Consortium, DIAMANTE, Chen, Shuibing, Stitzel, Michael L., Erdos, Michael R., Ovcharenko, Ivan, Collins, Francis S.
Publicado 2023

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

por Stančáková, Alena, Civelek, Mete, Saleem, Niyas K., Soininen, Pasi, Kangas, Antti J., Cederberg, Henna, Paananen, Jussi, Pihlajamäki, Jussi, Bonnycastle, Lori L., Morken, Mario A., Boehnke, Michael, Pajukanta, Päivi, Lusis, Aldons J., Collins, Francis S., Kuusisto, Johanna, Ala-Korpela, Mika, Laakso, Markku
Publicado 2012

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

por Bonnycastle, Lori L., Chines, Peter S., Hara, Takashi, Huyghe, Jeroen R., Swift, Amy J., Heikinheimo, Pirkko, Mahadevan, Jana, Peltonen, Sirkku, Huopio, Hanna, Nuutila, Pirjo, Narisu, Narisu, Goldfeder, Rachel L., Stitzel, Michael L., Lu, Simin, Boehnke, Michael, Urano, Fumihiko, Collins, Francis S., Laakso, Markku
Publicado 2013

Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men

por Mahendran, Yuvaraj, Vangipurapu, Jagadish, Cederberg, Henna, Stančáková, Alena, Pihlajamäki, Jussi, Soininen, Pasi, Kangas, Antti J., Paananen, Jussi, Civelek, Mete, Saleem, Niyas K., Pajukanta, Päivi, Lusis, Aldons J., Bonnycastle, Lori L., Morken, Mario A., Collins, Francis S., Mohlke, Karen L., Boehnke, Michael, Ala-Korpela, Mika, Kuusisto, Johanna, Laakso, Markku
Publicado 2013

Tissue-specific alternative splicing of TCF7L2

por Prokunina-Olsson, Ludmila, Welch, Cullan, Hansson, Ola, Adhikari, Neeta, Scott, Laura J., Usher, Nicolle, Tong, Maurine, Sprau, Andrew, Swift, Amy, Bonnycastle, Lori L., Erdos, Michael R., He, Zhi, Saxena, Richa, Harmon, Brennan, Kotova, Olga, Hoffman, Eric P., Altshuler, David, Groop, Leif, Boehnke, Michael, Collins, Francis S., Hall, Jennifer L.
Publicado 2009

Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes

por Gaulton, Kyle J., Willer, Cristen J., Li, Yun, Scott, Laura J., Conneely, Karen N., Jackson, Anne U., Duren, William L., Chines, Peter S., Narisu, Narisu, Bonnycastle, Lori L., Luo, Jingchun, Tong, Maurine, Sprau, Andrew G., Pugh, Elizabeth W., Doheny, Kimberly F., Valle, Timo T., Abecasis, Gonçalo R., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., Boehnke, Michael, Mohlke, Karen L.
Publicado 2008

SARS-CoV-2 infection induces beta cell transdifferentiation

por Tang, Xuming, Uhl, Skyler, Zhang, Tuo, Xue, Dongxiang, Li, Bo, Vandana, J. Jeya, Acklin, Joshua A., Bonnycastle, Lori L., Narisu, Narisu, Erdos, Michael R., Bram, Yaron, Chandar, Vasuretha, Chong, Angie Chi Nok, Lacko, Lauretta A., Min, Zaw, Lim, Jean K., Borczuk, Alain C., Xiang, Jenny, Naji, Ali, Collins, Francis S., Evans, Todd, Liu, Chengyang, tenOever, Benjamin R., Schwartz, Robert E., Chen, Shuibing
Publicado 2021

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

por Yin, Xianyong, Bose, Debraj, Kwon, Annie, Hanks, Sarah C., Jackson, Anne U., Stringham, Heather M., Welch, Ryan, Oravilahti, Anniina, Fernandes Silva, Lilian, Locke, Adam E., Fuchsberger, Christian, Service, Susan K., Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Morrison, Jean, Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Collins, Francis S., Mohlke, Karen L., Scott, Laura J., Fauman, Eric B., Burant, Charles, Boehnke, Michael, Laakso, Markku, Wen, Xiaoquan
Publicado 2022

Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci

por Service, Susan K., Teslovich, Tanya M., Fuchsberger, Christian, Ramensky, Vasily, Yajnik, Pranav, Koboldt, Daniel C., Larson, David E., Zhang, Qunyuan, Lin, Ling, Welch, Ryan, Ding, Li, McLellan, Michael D., O'Laughlin, Michele, Fronick, Catrina, Fulton, Lucinda L., Magrini, Vincent, Swift, Amy, Elliott, Paul, Jarvelin, Marjo-Riitta, Kaakinen, Marika, McCarthy, Mark I., Peltonen, Leena, Pouta, Anneli, Bonnycastle, Lori L., Collins, Francis S., Narisu, Narisu, Stringham, Heather M., Tuomilehto, Jaakko, Ripatti, Samuli, Fulton, Robert S., Sabatti, Chiara, Wilson, Richard K., Boehnke, Michael, Freimer, Nelson B.
Publicado 2014

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

por Scott, Laura J., Erdos, Michael R., Huyghe, Jeroen R., Welch, Ryan P., Beck, Andrew T., Wolford, Brooke N., Chines, Peter S., Didion, John P., Narisu, Narisu, Stringham, Heather M., Taylor, D. Leland, Jackson, Anne U., Vadlamudi, Swarooparani, Bonnycastle, Lori L., Kinnunen, Leena, Saramies, Jouko, Sundvall, Jouko, Albanus, Ricardo D'Oliveira, Kiseleva, Anna, Hensley, John, Crawford, Gregory E., Jiang, Hui, Wen, Xiaoquan, Watanabe, Richard M., Lakka, Timo A., Mohlke, Karen L., Laakso, Markku, Tuomilehto, Jaakko, Koistinen, Heikki A., Boehnke, Michael, Collins, Francis S., Parker, Stephen C. J.
Publicado 2016

Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

por Brotman, Sarah M., El-Sayed Moustafa, Julia S., Guan, Li, Broadaway, K. Alaine, Wang, Dongmeng, Jackson, Anne U., Welch, Ryan, Currin, Kevin W., Tomlinson, Max, Vadlamudi, Swarooparani, Stringham, Heather M., Roberts, Amy L., Lakka, Timo A., Oravilahti, Anniina, Silva, Lilian Fernandes, Narisu, Narisu, Erdos, Michael R., Yan, Tingfen, Bonnycastle, Lori L., Raulerson, Chelsea K., Raza, Yasrab, Yan, Xinyu, Parker, Stephen C.J., Kuusisto, Johanna, Pajukanta, Päivi, Tuomilehto, Jaakko, Collins, Francis S., Boehnke, Michael, Love, Michael I., Koistinen, Heikki A., Laakso, Markku, Mohlke, Karen L., Small, Kerrin S., Scott, Laura J.
Publicado 2023

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

por Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael
Publicado 2022

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

por Perry, John R.B., Weedon, Michael N., Langenberg, Claudia, Jackson, Anne U., Lyssenko, Valeriya, Sparsø, Thomas, Thorleifsson, Gudmar, Grallert, Harald, Ferrucci, Luigi, Maggio, Marcello, Paolisso, Giuseppe, Walker, Mark, Palmer, Colin N.A., Payne, Felicity, Young, Elizabeth, Herder, Christian, Narisu, Narisu, Morken, Mario A., Bonnycastle, Lori L., Owen, Katharine R., Shields, Beverley, Knight, Beatrice, Bennett, Amanda, Groves, Christopher J., Ruokonen, Aimo, Jarvelin, Marjo Riitta, Pearson, Ewan, Pascoe, Laura, Ferrannini, Ele, Bornstein, Stefan R., Stringham, Heather M., Scott, Laura J., Kuusisto, Johanna, Nilsson, Peter, Neptin, Malin, Gjesing, Anette P., Pisinger, Charlotta, Lauritzen, Torsten, Sandbaek, Annelli, Sampson, Mike, Zeggini, MAGIC, Ele, Lindgren, Cecilia M., Steinthorsdottir, Valgerdur, Thorsteinsdottir, Unnur, Hansen, Torben, Schwarz, Peter, Illig, Thomas, Laakso, Markku, Stefansson, Kari, Morris, Andrew D., Groop, Leif, Pedersen, Oluf, Boehnke, Michael, Barroso, Inês, Wareham, Nicholas J., Hattersley, Andrew T., McCarthy, Mark I., Frayling, Timothy M.
Publicado 2010

Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis

por Tenney, Alan P., Di Gioia, Silvio Alessandro, Webb, Bryn D., Chan, Wai-Man, de Boer, Elke, Garnai, Sarah J., Barry, Brenda J., Ray, Tammy, Kosicki, Michael, Robson, Caroline D., Zhang, Zhongyang, Collins, Thomas E., Gelber, Alon, Pratt, Brandon M., Fujiwara, Yuko, Varshney, Arushi, Lek, Monkol, Warburton, Peter E., Van Ryzin, Carol, Lehky, Tanya J., Zalewski, Christopher, King, Kelly A., Brewer, Carmen C., Thurm, Audrey, Snow, Joseph, Facio, Flavia M., Narisu, Narisu, Bonnycastle, Lori L., Swift, Amy, Chines, Peter S., Bell, Jessica L., Mohan, Suresh, Whitman, Mary C., Staffieri, Sandra E., Elder, James E., Demer, Joseph L., Torres, Alcy, Rachid, Elza, Al-Haddad, Christiane, Boustany, Rose-Mary, Mackey, David A., Brady, Angela F., Fenollar-Cortés, María, Fradin, Melanie, Kleefstra, Tjitske, Padberg, George W., Raskin, Salmo, Sato, Mario Teruo, Orkin, Stuart H., Parker, Stephen C. J., Hadlock, Tessa A., Vissers, Lisenka E. L. M., van Bokhoven, Hans, Jabs, Ethylin Wang, Collins, Francis S., Pennacchio, Len A., Manoli, Irini, Engle, Elizabeth C.
Publicado 2023