Lyso-glycosphingolipids: presence and consequences

por van Eijk, Marco, Ferraz, Maria J., Boot, Rolf G., Aerts, Johannes M.F.G.
Publicado 2020

Animal Models for the Study of Gaucher Disease

por Cabasso, Or, Kuppuramalingam, Aparna, Lelieveld, Lindsey, Van der Lienden, Martijn, Boot, Rolf, Aerts, Johannes M., Horowitz, Mia
Publicado 2023

Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions

por Kok, Ken, Zwiers, Kimberley C., Boot, Rolf G., Overkleeft, Hermen S., Aerts, Johannes M. F. G., Artola, Marta
Publicado 2021

Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages

por van der Lienden, Martijn J.C., Gaspar, Paulo, Boot, Rolf, Aerts, Johannes M.F.G., van Eijk, Marco
Publicado 2018

HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity

por van der Lienden, Martijn J. C., Aten, Jan, Boot, Rolf G., van Eijk, Marco, Aerts, Johannes M. F. G., Kuo, Chi‐Lin
Publicado 2022

Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

por Su, Qin, Schröder, Sybrin P., Lelieveld, Lindsey T., Ferraz, Maria J., Verhoek, Marri, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta, Kuo, Chi‐Lin
Publicado 2021

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

por Kallemeijn, Wouter W., Scheij, Saskia, Hoogendoorn, Sascha, Witte, Martin D., Herrera Moro Chao, Daniela, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M. F. G.
Publicado 2017

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

por Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T., Rowland, Rhianna J., van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado 2019

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.

por Lelieveld, Lindsey T., Gerhardt, Sophie, Maas, Saskia, Zwiers, Kimberley C., de Wit, Claire, Beijk, Ernst H., Ferraz, Maria J., Artola, Marta, Meijer, Annemarie H., Tudorache, Christian, Salvatori, Daniela, Boot, Rolf G., Aerts, Johannes M.F.G.
Publicado 2022

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

por van Rooden, Eva J., van Esbroeck, Annelot C. M., Baggelaar, Marc P., Deng, Hui, Florea, Bogdan I., Marques, André R. A., Ottenhoff, Roelof, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., van der Stelt, Mario
Publicado 2018

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

por Jiang, Jianbing, Kuo, Chi-Lin, Wu, Liang, Franke, Christian, Kallemeijn, Wouter W., Florea, Bogdan I., van Meel, Eline, van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2016

Correction to “Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes”

por Jiang, Jianbing, Kuo, Chi-Lin, Wu, Liang, Franke, Christian, Kallemeijn, Wouter W., Florea, Bogdan I., van Meel, Eline, van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2017

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

por Kramer, Gertjan, Wegdam, Wouter, Donker‐Koopman, Wilma, Ottenhoff, Roelof, Gaspar, Paulo, Verhoek, Marri, Nelson, Jessica, Gabriel, Tanit, Kallemeijn, Wouter, Boot, Rolf G., Laman, Jon D., Vissers, Johannes P.C., Cox, Timothy, Pavlova, Elena, Moran, Mary Teresa, Aerts, Johannes M., van Eijk, Marco
Publicado 2016

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

por Kytidou, Kassiani, Beenakker, Thomas J. M., Westerhof, Lotte B., Hokke, Cornelis H., Moolenaar, Geri F., Goosen, Nora, Mirzaian, Mina, Ferraz, Maria J., de Geus, Mark, Kallemeijn, Wouter W., Overkleeft, Herman S., Boot, Rolf G., Schots, Arjen, Bosch, Dirk, Aerts, Johannes M. F. G.
Publicado 2017

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

por Marques, André R. A., Aten, Jan, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Herrera Moro, Daniela, Claessen, Nike, Vinueza Veloz, María Fernanda, Zhou, Kuikui, Lin, Zhanmin, Mirzaian, Mina, Boot, Rolf G., De Zeeuw, Chris I., Overkleeft, Herman S., Yildiz, Yildiz, Aerts, Johannes M. F. G.
Publicado 2015

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

por Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.
Publicado 2021

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

por Herrera Moro Chao, Daniela, Kallemeijn, Wouter W., Marques, Andre R. A., Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C., Moeton, Martina, van Eijk, Marco, Boot, Rolf G., Kamphuis, Willem, Hol, Elly M., Aten, Jan, Overkleeft, Hermen S., Kalsbeek, Andries, Aerts, Johannes M. F. G.
Publicado 2015

Stabilization of Glucocerebrosidase by Active Site Occupancy

por Ben Bdira, Fredj, Kallemeijn, Wouter W., Oussoren, Saskia V., Scheij, Saskia, Bleijlevens, Boris, Florea, Bogdan I., van Roomen, Cindy P. A. A., Ottenhoff, Roelof, van Kooten, Marielle J. F. M., Walvoort, Marthe T. C., Witte, Martin D., Boot, Rolf G., Ubbink, Marcellus, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2017

Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies

por Aerts, Johannes M. F. G., Kallemeijn, Wouter W., Wegdam, Wouter, Joao Ferraz, Maria, van Breemen, Marielle J., Dekker, Nick, Kramer, Gertjan, Poorthuis, Ben J., Groener, Johanna E. M., Cox-Brinkman, Josanne, Rombach, Saskia M., Hollak, Carla E. M., Linthorst, Gabor E., Witte, Martin D., Gold, Henrik, van der Marel, Gijs A., Overkleeft, Herman S., Boot, Rolf G.
Publicado 2011

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

por Lahav, Daniël, Liu, Bing, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Wennekes, Tom, Ghisaidoobe, Amar T., Breen, Imogen, Ferraz, Maria J., Kuo, Chi-Lin, Wu, Liang, Geurink, Paul P., Ovaa, Huib, van der Marel, Gijsbert A., van der Stelt, Mario, Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado 2017