The unfolded protein response and its relevance to connective tissue diseases

por Boot-Handford, Raymond P., Briggs, Michael D.
Publicado 2009

Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene

por Forouhan, Mitra, Sonntag, Stephan, Boot-Handford, Raymond P
Publicado 2018

PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes

por Soul, Jamie, Hardingham, Timothy E., Boot-Handford, Raymond P., Schwartz, Jean-Marc
Publicado 2015

Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress without Triggering the Unfolded Protein Response

por Kung, Louise H. W., Rajpar, M. Helen, Briggs, Michael D., Boot-Handford, Raymond P.
Publicado 2012

Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

por Kung, Louise H. W., Rajpar, M. Helen, Preziosi, Richard, Briggs, Michael D., Boot-Handford, Raymond P.
Publicado 2015

The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio

por Huxley-Jones, Julie, Clarke, Toni-Kim, Beck, Christine, Toubaris, George, Robertson, David L, Boot-Handford, Raymond P
Publicado 2007

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family

por Ewan, Richard, Huxley-Jones, Julie, Mould, A Paul, Humphries, Martin J, Robertson, David L, Boot-Handford, Raymond P
Publicado 2005

Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation

por Bell, Peter A, Piróg, Katarzyna A, Fresquet, Maryline, Thornton, David J, Boot-Handford, Raymond P, Briggs, Michael D
Publicado 2012

A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia

por Piróg, Katarzyna A., Jaka, Oihane, Katakura, Yoshihisa, Meadows, Roger S., Kadler, Karl E., Boot-Handford, Raymond P., Briggs, Michael D.
Publicado 2010

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

por Gualeni, Benedetta, Rajpar, M. Helen, Kellogg, Aaron, Bell, Peter A., Arvan, Peter, Boot-Handford, Raymond P., Briggs, Michael D.
Publicado 2013

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

por Hartley, Claire L., Edwards, Sarah, Mullan, Lorna, Bell, Peter A., Fresquet, Maryline, Boot-Handford, Raymond P., Briggs, Michael D.
Publicado 2013

Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia

por Piróg, Katarzyna A., Irman, Andreja, Young, Siobhan, Halai, Poonam, Bell, Peter A., Boot-Handford, Raymond P., Briggs, Michael D.
Publicado 2014

Collagen XXVII Organises the Pericellular Matrix in the Growth Plate

por Plumb, Darren A., Ferrara, Laila, Torbica, Tanja, Knowles, Lynnette, Mironov, Aleksandr, Kadler, Karl E., Briggs, Michael D., Boot-Handford, Raymond P.
Publicado 2011

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

por Kung, Louise H. W., Mullan, Lorna, Soul, Jamie, Wang, Ping, Mori, Kazutoshi, Bateman, John F., Briggs, Michael D., Boot-Handford, Raymond P.
Publicado 2019

Identification of multiple integrin β1 homologs in zebrafish (Danio rerio)

por Mould, A Paul, McLeish, Jennifer A, Huxley-Jones, Julie, Goonesinghe, Alexander C, Hurlstone, Adam FL, Boot-Handford, Raymond P, Humphries, Martin J
Publicado 2006

Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

por Cameron, Trevor L., Bell, Katrina M., Tatarczuch, Liliana, Mackie, Eleanor J., Rajpar, M. Helen, McDermott, Ben T., Boot-Handford, Raymond P., Bateman, John F.
Publicado 2011

A Novel Form of Chondrocyte Stress is Triggered by a COMP Mutation Causing Pseudoachondroplasia

por Suleman, Farhana, Gualeni, Benedetta, Gregson, Hannah J, Leighton, Matthew P, Piróg, Katarzyna A, Edwards, Sarah, Holden, Paul, Boot-Handford, Raymond P, Briggs, Michael D
Publicado 2012

Arhgap28 Is a RhoGAP that Inactivates RhoA and Downregulates Stress Fibers

por Yeung, Ching-Yan Chloé, Taylor, Susan H., Garva, Richa, Holmes, David F., Zeef, Leo A., Soininen, Raija, Boot-Handford, Raymond P., Kadler, Karl E.
Publicado 2014

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

por Bell, Peter A., Wagener, Raimund, Zaucke, Frank, Koch, Manuel, Selley, Julian, Warwood, Stacey, Knight, David, Boot-Handford, Raymond P., Thornton, David J., Briggs, Michael D.
Publicado 2013

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

por Cameron, Trevor L., Bell, Katrina M., Gresshoff, Irma L., Sampurno, Lisa, Mullan, Lorna, Ermann, Joerg, Glimcher, Laurie H., Boot-Handford, Raymond P., Bateman, John F.
Publicado 2015