An efficient and versatile synthesis of GlcNAcstatins—potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

por Borodkin, Vladimir S., van Aalten, Daan M.F.
Publicado 2010

Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

por Pathak, Shalini, Dorfmueller, Helge C., Borodkin, Vladimir S., van Aalten, Daan M.F.
Publicado 2008

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

por Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, van Aalten, Daan M. F.
Publicado 2009

Human OGA binds substrates in a conserved peptide recognition groove

por Schimpl, Marianne, Schüttelkopf, Alexander W., Borodkin, Vladimir S., van Aalten, Daan M. F.
Publicado 2010

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

por Schimpl, Marianne, Borodkin, Vladimir S., Gray, Lindsey J., van Aalten, Daan M.F.
Publicado 2012

A Structural and Biochemical Model of Processive Chitin Synthesis

por Dorfmueller, Helge C., Ferenbach, Andrew T., Borodkin, Vladimir S., van Aalten, Daan M. F.
Publicado 2014

Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors

por Rafie, Karim, Gorelik, Andrii, Trapannone, Riccardo, Borodkin, Vladimir S., van Aalten, Daan M. F.
Publicado 2018

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

por Pathak, Shalini, Borodkin, Vladimir S, Albarbarawi, Osama, Campbell, David G, Ibrahim, Adel, van Aalten, Daan MF
Publicado 2012

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats

por Rafie, Karim, Raimi, Olawale, Ferenbach, Andrew T., Borodkin, Vladimir S., Kapuria, Vaibhav, van Aalten, Daan M. F.
Publicado 2017

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

por Gorelik, Andrii, Galan Bartual, Sergio, Borodkin, Vladimir S., Varghese, Joby, Ferenbach, Andrew T., van Aalten, Daan M. F.
Publicado 2019

Substrate and product analogues as human O-GlcNAc transferase inhibitors

por Dorfmueller, Helge C., Borodkin, Vladimir S., Blair, David E., Pathak, Shalini, Navratilova, Iva, van Aalten, Daan M. F.
Publicado 2010

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes

por Kapuria, Vaibhav, Röhrig, Ute F., Bhuiyan, Tanja, Borodkin, Vladimir S., van Aalten, Daan M.F., Zoete, Vincent, Herr, Winship
Publicado 2016

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

por Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, Zheng, Xiaowei, Kime, Robert, Read, Kevin D., van Aalten, Daan M.F.
Publicado 2010

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

por Borodkin, Vladimir S., Schimpl, Marianne, Gundogdu, Mehmet, Rafie, Karim, Dorfmueller, Helge C., Robinson, David A., vanAalten, Daan M. F.
Publicado 2014

The conserved threonine-rich region of the HCF-1(PRO) repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities

por Kapuria, Vaibhav, Röhrig, Ute F., Waridel, Patrice, Lammers, Fabienne, Borodkin, Vladimir S., van Aalten, Daan M. F., Zoete, Vincent, Herr, Winship
Publicado 2018

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

por Raimi, Olawale G., Hurtado-Guerrero, Ramon, Borodkin, Vladimir, Ferenbach, Andrew, Urbaniak, Michael D., Ferguson, Michael A. J., van Aalten, Daan M. F.
Publicado 2020

Structural insights into mechanism and specificity of O-GlcNAc transferase

por Clarke, Andrew J, Hurtado-Guerrero, Ramon, Pathak, Shalini, Schüttelkopf, Alexander W, Borodkin, Vladimir, Shepherd, Sharon M, Ibrahim, Adel F M, van Aalten, Daan M F
Publicado 2008

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

por Pravata, Veronica M., Muha, Villo, Gundogdu, Mehmet, Ferenbach, Andrew T., Kakade, Poonam S., Vandadi, Vasudha, Wilmes, Ariane C., Borodkin, Vladimir S., Joss, Shelagh, Stavridis, Marios P., van Aalten, Daan M. F.
Publicado 2019

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

por Schimpl, Marianne, Zheng, Xiaowei, Borodkin, Vladimir S., Blair, David E., Ferenbach, Andrew T., Schüttelkopf, Alexander W., Navratilova, Iva, Aristotelous, Tonia, Albarbarawi, Osama, Robinson, David A., Macnaughtan, Megan A., van Aalten, Daan M.F.
Publicado 2012