Chemical and Structural Strategies to Selectively Target mTOR Kinase

por Borsari, Chiara, De Pascale, Martina, Wymann, Matthias P.
Publicado 2021

Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology

por Borsari, Chiara, Trader, Darci J., Tait, Annalisa, Costi, Maria P.
Publicado 2020

Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability

por Borsari, Chiara, Keles, Erhan, Treyer, Andrea, De Pascale, Martina, Hebeisen, Paul, Hamburger, Matthias, Wymann, Matthias P.
Publicado 2021

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

por Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E
Publicado 2021

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety

por Borsari, Chiara, Rageot, Denise, Beaufils, Florent, Bohnacker, Thomas, Keles, Erhan, Buslov, Ivan, Melone, Anna, Sele, Alexander M., Hebeisen, Paul, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P.
Publicado 2019

Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives

por Galbiati, Andrea, Zana, Aureliano, Borsari, Chiara, Persico, Marco, Bova, Stefania, Tkachuk, Oleh, Corfu, Alexandra Ioana, Tamborini, Lucia, Basilico, Nicoletta, Fattorusso, Caterina, Bruno, Stefano, Parapini, Silvia, Conti, Paola
Publicado 2023

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

por Borsari, Chiara, Keles, Erhan, McPhail, Jacob A., Schaefer, Alexander, Sriramaratnam, Rohitha, Goch, Wojciech, Schaefer, Thorsten, De Pascale, Martina, Bal, Wojciech, Gstaiger, Matthias, Burke, John E., Wymann, Matthias P.
Publicado 2022

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

por Di Pisa, Flavio, Landi, Giacomo, Dello Iacono, Lucia, Pozzi, Cecilia, Borsari, Chiara, Ferrari, Stefania, Santucci, Matteo, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Moraes, Carolina B., Alcantara, Laura M., Fontana, Vanessa, Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Behrens, Birte, Pöhner, Ina, Wade, Rebecca C., Costi, Maria Paola, Mangani, Stefano
Publicado 2017

Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids

por Magoulas, George E., Afroudakis, Pantelis, Georgikopoulou, Kalliopi, Roussaki, Marina, Borsari, Chiara, Fotopoulou, Theano, Santarem, Nuno, Barrias, Emile, Tejera Nevado, Paloma, Hachenberg, Julia, Bifeld, Eugenia, Ellinger, Bernhard, Kuzikov, Maria, Fragiadaki, Irini, Scoulica, Effie, Clos, Joachim, Gul, Sheraz, Costi, Maria Paola, de Souza, Wanderley, Prousis, Kyriakos C., Cordeiro da Silva, Anabela, Calogeropoulou, Theodora
Publicado 2021

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

por Moraes, Carolina B., Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Calogeropoulou, Theodora, Prousis, Kyriakos C., Mangani, Stefano, Di Pisa, Flavio, Landi, Giacomo, Iacono, Lucia Dello, Pozzi, Cecilia, Freitas-Junior, Lucio H., dos Santos Pascoalino, Bruno, Bertolacini, Claudia P., Behrens, Birte, Keminer, Oliver, Leu, Jennifer, Wolf, Markus, Reinshagen, Jeanette, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Venturelli, Alberto, Wrigley, Stephen, Karunakaran, Deepa, Kebede, Bethlehem, Pöhner, Ina, Müller, Wolfgang, Panecka-Hofman, Joanna, Wade, Rebecca C., Fenske, Martina, Clos, Joachim, Alunda, José María, Corral, María Jesús, Uliassi, Elisa, Bolognesi, Maria Laura, Linciano, Pasquale, Quotadamo, Antonio, Ferrari, Stefania, Santucci, Matteo, Borsari, Chiara, Costi, Maria Paola, Gul, Sheraz
Publicado 2019