Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic targ...

por Perl, Andras, Hanczko, Robert, Lai, Zhi-Wei, Oaks, Zachary, Kelly, Ryan, Borsuk, Rebecca, Asara, John M., Phillips, Paul E.
Publicado 2015

mTOR activation triggers proinflammatory expansion of IL-4-producing and necrosis-prone double-negative T cells, precedes flares, and serves as target for treatment in patients wit...

por Lai, Zhi-Wei, Borsuk, Rebecca, Shadakshari, Ashwini, Yu, Jianghong, Dawood, Maha, Garcia, Ricardo, Francis, Lisa, Tily, Hajra, Bartos, Adam, Faraone, Stephen V, Phillips, Paul, Perl, Andras
Publicado 2014