Mechanisms of Isoform Specific Rap2 Signaling during Enterocytic Brush Border Formation

por Bruurs, Lucas J. M., Bos, Johannes L.
Publicado 2014

Rap1 signaling in endothelial barrier control

por Pannekoek, Willem-Jan, Post, Anneke, Bos, Johannes L
Publicado 2014

Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions

por Pannekoek, Willem-Jan, Vliem, Marjolein J., Bos, Johannes L.
Publicado 2018

The PDZ Domain of the Guanine Nucleotide Exchange Factor PDZGEF Directs Binding to Phosphatidic Acid during Brush Border Formation

por Consonni, Sarah V., Brouwer, Patricia M., van Slobbe, Eleonora S., Bos, Johannes L.
Publicado 2014

Evolution of the TOR Pathway

por van Dam, Teunis J. P., Zwartkruis, Fried J. T., Bos, Johannes L., Snel, Berend
Publicado 2011

Rap1 and Rap2 Antagonistically Control Endothelial Barrier Resistance

por Pannekoek, Willem-Jan, Linnemann, Jelena R., Brouwer, Patricia M., Bos, Johannes L., Rehmann, Holger
Publicado 2013

A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization

por Bruurs, Lucas J. M., Zwakenberg, Susan, van der Net, Mirjam C., Zwartkruis, Fried J., Bos, Johannes L.
Publicado 2017

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization

por Bruurs, Lucas J. M., van der Net, Mirjam C., Zwakenberg, Susan, Zwartkruis, Fried J. T., Bos, Johannes L.
Publicado 2018

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β(2)-adrenergic receptor

por Rangarajan, Savithri, Enserink, Jorrit M., Kuiperij, H. Bea, de Rooij, Johan, Price, Leo S., Schwede, Frank, Bos, Johannes L.
Publicado 2003

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation

por Ross, Sarah H., Spanjaard, Emma, Post, Anneke, Vliem, Marjolein J., Kristyanto, Hendy, Bos, Johannes L., de Rooij, Johan
Publicado 2012

CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition

por Post, Jasmin B., Hami, Nizar, Mertens, Alexander E.E., Elfrink, Suraya, Bos, Johannes L., Snippert, Hugo J.G.
Publicado 2019

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity

por Gloerich, Martijn, Vliem, Marjolein J., Prummel, Esther, Meijer, Lars A.T., Rensen, Marije G.A., Rehmann, Holger, Bos, Johannes L.
Publicado 2011

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size

por Bruurs, Lucas J. M., van der Net, Mirjam C., Zwakenberg, Susan, Rosendahl Huber, Axel K. M., Post, Anneke, Zwartkruis, Fried J., Bos, Johannes L.
Publicado 2018

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

por Reedquist, Kris A., Ross, Ewan, Koop, Elianne A., Wolthuis, Rob M.F., Zwartkruis, Fried J.T., van Kooyk, Yvette, Salmon, Mike, Buckley, Christopher D., Bos, Johannes L.
Publicado 2000

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

por Bruurs, Lucas J.M., Donker, Lisa, Zwakenberg, Susan, Zwartkruis, Fried J., Begthel, Harry, Knisely, A.S., Posthuma, George, van de Graaf, Stan F.J., Paulusma, Coen C., Bos, Johannes L.
Publicado 2015

Structure-Guided Design of Selective Epac1 and Epac2 Agonists

por Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N., Hadders, Michael A., Wienk, Hans, Ellenbroek, Johanne H., de Koning, Eelco J. P., Bos, Johannes L., Herberg, Friedrich W., Genieser, Hans-Gottfried, Janssen, Richard A. J., Rehmann, Holger
Publicado 2015

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

por Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Publicado 2016

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling

por Ponsioen, Bas, Post, Jasmin B., des Amorie, Julian R. Buissant, Laskaris, Dimitrios, van Ineveld, Ravian L., Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F., Vries, Rob G.J., Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B., Trusolino, Livio, Bos, Johannes L., Snippert, Hugo J.G.
Publicado 2021