An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

por Rotunno, Melissa S., Bosco, Daryl A.
Publicado 2013

Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Substantially Stabilizes Proteins

por Gao, Jianmin, Bosco, Daryl A., Powers, Evan T., Kelly, Jeffery W.
Publicado 2009

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS

por Sama, Reddy Ranjith Kumar, Ward, Catherine L., Bosco, Daryl A.
Publicado 2014

Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatu...

por Kahriman, Aydan, Bouley, James, Smith, Thomas W., Bosco, Daryl A., Woerman, Amanda L., Henninger, Nils
Publicado 2021

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics

por Baron, Desiree M, Kaushansky, Laura J, Ward, Catherine L, Sama, Reddy Ranjith K, Chian, Ru-Ju, Boggio, Kristin J, Quaresma, Alexandre J C, Nickerson, Jeffrey A, Bosco, Daryl A
Publicado 2013

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

por Ju, Shulin, Tardiff, Daniel F., Han, Haesun, Divya, Kanneganti, Zhong, Quan, Maquat, Lynne E., Bosco, Daryl A., Hayward, Lawrence J., Brown, Robert H., Lindquist, Susan, Ringe, Dagmar, Petsko, Gregory A.
Publicado 2011

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

por Sama, Reddy Ranjith K., Fallini, Claudia, Gatto, Rodolfo, McKeon, Jeanne E., Song, Yuyu, Rotunno, Melissa S., Penaranda, Saul, Abdurakhmanov, Izrail, Landers, John E., Morfini, Gerardo, Brady, Scott T., Bosco, Daryl A.
Publicado 2017

Identification of Human Monoclonal Antibodies Specific for Human SOD1 Recognizing Distinct Epitopes and Forms of SOD1

por Broering, Teresa J., Wang, Hongyan, Boatright, Naomi K., Wang, Yang, Baptista, Katherine, Shayan, Gilda, Garrity, Kerry A., Kayatekin, Can, Bosco, Daryl A., Matthews, C. Robert, Ambrosino, Donna M., Xu, Zuoshang, Babcock, Gregory J.
Publicado 2013

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons

por Kumar, Meenakshi Sundaram, Fowler-Magaw, Megan E., Kulick, Daniel, Boopathy, Sivakumar, Gadd, Del Hayden, Rotunno, Melissa, Douthwright, Catherine, Golebiowski, Diane, Yusuf, Issa, Xu, Zuoshang, Brown, Robert H., Sena-Esteves, Miguel, O’Neil, Alison L., Bosco, Daryl A.
Publicado 2022

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

por Bosco, Daryl A., Morfini, Gerardo, Karabacak, N. Murat, Song, Yuyu, Gros-Louis, Francois, Pasinelli, Piera, Goolsby, Holly, Fontaine, Benjamin A., Lemay, Nathan, McKenna-Yasek, Diane, Frosch, Matthew P., Agar, Jeffery N., Julien, Jean-Pierre, Brady, Scott T., Brown, Robert H.
Publicado 2010

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

por Morfini, Gerardo A., Bosco, Daryl A., Brown, Hannah, Gatto, Rodolfo, Kaminska, Agnieszka, Song, Yuyu, Molla, Linda, Baker, Lisa, Marangoni, M. Natalia, Berth, Sarah, Tavassoli, Ehsan, Bagnato, Carolina, Tiwari, Ashutosh, Hayward, Lawrence J., Pigino, Gustavo F., Watterson, D. Martin, Huang, Chun-Fang, Banker, Gary, Brown, Robert H., Brady, Scott T.
Publicado 2013

Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

por Wu, Chi-Hong, Fallini, Claudia, Ticozzi, Nicola, Keagle, Pamela J., Sapp, Peter C., Piotrowska, Katarzyna, Lowe, Patrick, Koppers, Max, McKenna-Yasek, Diane, Baron, Desiree M., Kost, Jason E., Gonzalez-Perez, Paloma, Fox, Andrew D., Adams, Jenni, Taroni, Franco, Tiloca, Cinzia, Leclerc, Ashley Lyn, Chafe, Shawn C., Mangroo, Dev, Moore, Melissa J., Zitzewitz, Jill A., Xu, Zuo-Shang, van den Berg, Leonard H., Glass, Jonathan D., Siciliano, Gabriele, Cirulli, Elizabeth T., Goldstein, David B., Salachas, Francois, Meininger, Vincent, Rossoll, Wilfried, Ratti, Antonia, Gellera, Cinzia, Bosco, Daryl A., Bassell, Gary J., Silani, Vincenzo, Drory, Vivian E., Brown, Robert H., Landers, John E.
Publicado 2012