Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

por Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita V., Crowell, Susan R.
Publicado 2021

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

por Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew
Publicado 2022

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

por Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
Publicado 2011

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

por Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.
Publicado 2014

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

por Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
Publicado 2014

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

por Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A, Khawli, Leslie, Shen, Ben-Quan
Publicado 2014

Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice

por Dominguez, Sara L., Hegde, Ganapati V., Hanson, Jesse E., Xiang, Hong, Mandikian, Danielle, Boswell, C. Andrew, Chiu, Cecilia, Wu, Yan, Tsai, Siao Ping, Fleck, Daniel, Weber, Martin, Ngu, Hai, Scearce-Levie, Kimberly, Jackson, Erica L.
Publicado 2018

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging

por Mandikian, Danielle, Rafidi, Hanine, Adhikari, Pragya, Venkatraman, Priya, Nazarova, Lidia, Fung, Gabriel, Figueroa, Isabel, Ferl, Gregory Z., Ulufatu, Sheila, Ho, Jason, McCaughey, Cynthia, Lau, Jeffrey, Yu, Shang-Fan, Prabhu, Saileta, Sadowsky, Jack, Boswell, C. Andrew
Publicado 2018

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

por Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Publicado 2019

Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice

por Lombana, T. Noelle, Rajan, Sharmila, Zorn, Julie A., Mandikian, Danielle, Chen, Eugene C., Estevez, Alberto, Yip, Victor, Bravo, Daniel D., Phung, Wilson, Farahi, Farzam, Viajar, Sharon, Lee, Sophia, Gill, Avinash, Sandoval, Wendy, Wang, Jianyong, Ciferri, Claudio, Boswell, C. Andrew, Matsumoto, Marissa L., Spiess, Christoph
Publicado 2019

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

por Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T., Pillow, Thomas H., Phillips, Gail D., Rowntree, Rebecca K, Boswell, C. Andrew, Kozak, Katherine R., Polson, Andrew G., Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S., Agard, Nicholas J.
Publicado 2020