Particle MCMC algorithms and architectures for accelerating inference in state-space models()

por Mingas, Grigorios, Bottolo, Leonardo, Bouganis, Christos-Savvas
Publicado 2017

WGBSSuite: simulating whole-genome bisulphite sequencing data and benchmarking differential DNA methylation analysis tools

por Rackham, Owen J. L., Dellaportas, Petros, Petretto, Enrico, Bottolo, Leonardo
Publicado 2015

Multi-tissue Analysis of Co-expression Networks by Higher-Order Generalized Singular Value Decomposition Identifies Functionally Coherent Transcriptional Modules

por Xiao, Xiaolin, Moreno-Moral, Aida, Rotival, Maxime, Bottolo, Leonardo, Petretto, Enrico
Publicado 2014

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age

por Inshaw, Jamie R. J., Walker, Neil M., Wallace, Chris, Bottolo, Leonardo, Todd, John A.
Publicado 2017

A computationally efficient Bayesian seemingly unrelated regressions model for high-dimensional quantitative trait loci discovery

por Bottolo, Leonardo, Banterle, Marco, Richardson, Sylvia, Ala-Korpela, Mika, Järvelin, Marjo-Riitta, Lewin, Alex
Publicado 2021

EPISPOT: An epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies

por Ruffieux, Hélène, Fairfax, Benjamin P., Nassiri, Isar, Vigorito, Elena, Wallace, Chris, Richardson, Sylvia, Bottolo, Leonardo
Publicado 2021

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

por Zuber, Verena, Gill, Dipender, Ala-Korpela, Mika, Langenberg, Claudia, Butterworth, Adam, Bottolo, Leonardo, Burgess, Stephen
Publicado 2020

MethylCal: Bayesian calibration of methylation levels

por Ochoa, Eguzkine, Zuber, Verena, Fernandez-Jimenez, Nora, Bilbao, Jose Ramon, Clark, Graeme R, Maher, Eamonn R, Bottolo, Leonardo
Publicado 2019

ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration

por Bottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Langley, Sarah R., Petretto, Enrico, Tiret, Laurence, Tregouet, David, Richardson, Sylvia
Publicado 2011

Leveraging genetic data to elucidate the relationship between Covid-19 and ischemic stroke

por Zuber, Verena, Cameron, Alan, Myserlis, Evangelos P., Bottolo, Leonardo, Fernandez-Cadenas, Israel, Burgess, Stephen, Anderson, Christopher D., Dawson, Jesse, Gill, Dipender
Publicado 2021

Leveraging Genetic Data to Elucidate the Relationship Between COVID‐19 and Ischemic Stroke

por Zuber, Verena, Cameron, Alan, Myserlis, Evangelos P., Bottolo, Leonardo, Fernandez‐Cadenas, Israel, Burgess, Stephen, Anderson, Christopher D., Dawson, Jesse, Gill, Dipender
Publicado 2021

MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

por Lewin, Alex, Saadi, Habib, Peters, James E., Moreno-Moral, Aida, Lee, James C., Smith, Kenneth G. C., Petretto, Enrico, Bottolo, Leonardo, Richardson, Sylvia
Publicado 2016

Leptin-Mediated Changes in the Human Metabolome

por Lawler, Katherine, Huang-Doran, Isabel, Sonoyama, Takuhiro, Collet, Tinh-Hai, Keogh, Julia M, Henning, Elana, O’Rahilly, Stephen, Bottolo, Leonardo, Farooqi, I Sadaf
Publicado 2020

A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation

por Rackham, Owen J. L., Langley, Sarah R., Oates, Thomas, Vradi, Eleni, Harmston, Nathan, Srivastava, Prashant K., Behmoaras, Jacques, Dellaportas, Petros, Bottolo, Leonardo, Petretto, Enrico
Publicado 2017

New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach

por Petretto, Enrico, Bottolo, Leonardo, Langley, Sarah R., Heinig, Matthias, McDermott-Roe, Chris, Sarwar, Rizwan, Pravenec, Michal, Hübner, Norbert, Aitman, Timothy J., Cook, Stuart A., Richardson, Sylvia
Publicado 2010

Molecular characterisation of 36 multilocus imprinting disturbance (MLID) patients: a comprehensive approach

por Bilo, Larissa, Ochoa, Eguzkine, Lee, Sunwoo, Dey, Daniela, Kurth, Ingo, Kraft, Florian, Rodger, Fay, Docquier, France, Toribio, Ana, Bottolo, Leonardo, Binder, Gerhard, Fekete, György, Elbracht, Miriam, Maher, Eamonn R., Begemann, Matthias, Eggermann, Thomas
Publicado 2023

Metabolic effects of bezafibrate in mitochondrial disease

por Steele, Hannah, Gomez‐Duran, Aurora, Pyle, Angela, Hopton, Sila, Newman, Jane, Stefanetti, Renae J, Charman, Sarah J, Parikh, Jehill D, He, Langping, Viscomi, Carlo, Jakovljevic, Djordje G, Hollingsworth, Kieren G, Robinson, Alan J, Taylor, Robert W, Bottolo, Leonardo, Horvath, Rita, Chinnery, Patrick F
Publicado 2020

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease

por Levin, Michael G., Zuber, Verena, Walker, Venexia M., Klarin, Derek, Lynch, Julie, Malik, Rainer, Aday, Aaron W., Bottolo, Leonardo, Pradhan, Aruna D., Dichgans, Martin, Chang, Kyong-Mi, Rader, Daniel J., Tsao, Philip S., Voight, Benjamin F., Gill, Dipender, Burgess, Stephen, Damrauer, Scott M.
Publicado 2021

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

por Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan
Publicado 2021

Genotype, extrapyramidal features, and severity of variant ataxia‐telangiectasia

por Schon, Katherine, van Os, Nienke J.H., Oscroft, Nicholas, Baxendale, Helen, Scoffings, Daniel, Ray, Julian, Suri, Mohnish, Whitehouse, William P., Mehta, Puja R., Everett, Natasha, Bottolo, Leonardo, van de Warrenburg, Bart P., Byrd, Philip J., Weemaes, Corry, Willemsen, Michel A., Tischkowitz, Marc, Taylor, A. Malcolm, Hensiek, Anke E.
Publicado 2019