Protein Crystallography in Vaccine Research and Development

por Malito, Enrico, Carfi, Andrea, Bottomley, Matthew J.
Publicado 2015

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

por Bottomley, Matthew J., Thomson, Jason, Harwood, Catherine, Leigh, Irene
Publicado 2019

Self-assembling protein nanoparticles in the design of vaccines

por López-Sagaseta, Jacinto, Malito, Enrico, Rappuoli, Rino, Bottomley, Matthew J.
Publicado 2015

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

por Rappuoli, Rino, Bottomley, Matthew J., D’Oro, Ugo, Finco, Oretta, De Gregorio, Ennio
Publicado 2016

Application of Operational Tolerance Signatures Are Limited by Variability and Type of Immunosuppression in Renal Transplant Recipients: A Cross-Sectional Study

por Bottomley, Matthew J., Chen, Mian, Fuggle, Sue, Harden, Paul N., Wood, Kathryn J.
Publicado 2016

The COVID-19 Pandemic Is Associated with Reduced Survival after Pancreatic Ductal Adenocarcinoma Diagnosis: A Single-Centre Retrospective Analysis

por Madge, Oliver, Brodey, Alexandra, Bowen, Jordan, Nicholson, George, Sivakumar, Shivan, Bottomley, Matthew J.
Publicado 2022

Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-T...

por Bottomley, Matthew J., Harden, Paul N., Wood, Kathryn J., Hester, Joanna, Issa, Fadi
Publicado 2022

Safety and pharmacokinetic profile of apixaban in end‐stage renal disease: A real‐world analysis

por Tseng, Chen I., Roddick, Alistair J., Bottomley, Matthew J., Shapiro, Susan, Udayaraj, Udaya
Publicado 2022

Apo, Zn(2+)-bound and Mn(2+)-bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius

por Abate, Francesca, Malito, Enrico, Cozzi, Roberta, Lo Surdo, Paola, Maione, Domenico, Bottomley, Matthew J.
Publicado 2014

In Vivo Gene Expression Profiling of Staphylococcus aureus during Infection Informs Design of Stemless Leukocidins LukE and -D as Detoxified Vaccine Candidates

por Haag, Andreas F., Liljeroos, Lassi, Donato, Paolo, Pozzi, Clarissa, Brignoli, Tarcisio, Bottomley, Matthew J., Bagnoli, Fabio, Delany, Isabel
Publicado 2023

Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

por López-Sagaseta, Jacinto, Beernink, Peter T., Bianchi, Federica, Santini, Laura, Frigimelica, Elisabetta, Lucas, Alexander H., Pizza, Mariagrazia, Bottomley, Matthew J.
Publicado 2018

Research engagement by British early-career practitioners in nephrology: a multidisciplinary survey

por Bottomley, Matthew J, Beckwith, Hannah, McMahon, Aisling, Nation, Michael, Wheeler, David C, Greenwood, Sharlene, Hughes, Jeremy, Sheerin, Neil S
Publicado 2022

Structure and Assembly of Group B Streptococcus Pilus 2b Backbone Protein

por Cozzi, Roberta, Malito, Enrico, Lazzarin, Maddalena, Nuccitelli, Annalisa, Castagnetti, Andrea, Bottomley, Matthew J., Margarit, Immaculada, Maione, Domenico, Rinaudo, C. Daniela
Publicado 2015

An observational study of patient characteristics and mortality following hypoglycemia in the community

por Elwen, Francesca R, Huskinson, Alice, Clapham, Linda, Bottomley, Matthew J, Heller, Simon R, James, Cathryn, Abbas, Afroze, Baxter, Paul, Ajjan, Ramzi A
Publicado 2015

Neisseria meningitidis factor H binding protein bound to monoclonal antibody JAR5: implications for antibody synergy

por Malito, Enrico, Lo Surdo, Paola, Veggi, Daniele, Santini, Laura, Stefek, Heather, Brunelli, Brunella, Luzzi, Enrico, Bottomley, Matthew J., Beernink, Peter T., Scarselli, Maria
Publicado 2016

Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096

por Veggi, Daniele, Malito, Enrico, Lo Surdo, Paola, Pansegrau, Werner, Rippa, Valentina, Wahome, Newton, Savino, Silvana, Masignani, Vega, Pizza, Mariagrazia, Bottomley, Matthew J.
Publicado 2022

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

por Org, Tõnis, Chignola, Francesca, Hetényi, Csaba, Gaetani, Massimiliano, Rebane, Ana, Liiv, Ingrid, Maran, Uko, Mollica, Luca, Bottomley, Matthew J, Musco, Giovanna, Peterson, Pärt
Publicado 2008

Structural Basis for Group B Streptococcus Pilus 1 Sortases C Regulation and Specificity

por Cozzi, Roberta, Prigozhin, Daniil, Rosini, Roberto, Abate, Francesca, Bottomley, Matthew J., Grandi, Guido, Telford, John L., Rinaudo, C. Daniela, Maione, Domenico, Alber, Tom
Publicado 2012

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

por Liguori, Alessia, Malito, Enrico, Lo Surdo, Paola, Fagnocchi, Luca, Cantini, Francesca, Haag, Andreas F., Brier, Sébastien, Pizza, Mariagrazia, Delany, Isabel, Bottomley, Matthew J.
Publicado 2016

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody

por Maritan, Martina, Veggi, Daniele, Cozzi, Roberta, Dello Iacono, Lucia, Bartolini, Erika, Lo Surdo, Paola, Maruggi, Giulietta, Spraggon, Glen, Bottomley, Matthew J., Malito, Enrico
Publicado 2018