Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments

por Loo, Lit-Hsin, Bougen-Zhukov, Nicola Michelle, Tan, Wei-Ling Cecilia
Publicado 2017

Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking

por Brew, Tom, Bougen-Zhukov, Nicola, Mitchell, Wilson, Decourtye, Lyvianne, Schulpen, Emily, Nouri, Yasmin, Godwin, Tanis, Guilford, Parry
Publicado 2021

E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

por Decourtye-Espiard, Lyvianne, Bougen-Zhukov, Nicola, Godwin, Tanis, Brew, Tom, Schulpen, Emily, Black, Michael A., Guilford, Parry
Publicado 2021

E-Cadherin-Deficient Cells Are Sensitive to the Multikinase Inhibitor Dasatinib

por Bougen-Zhukov, Nicola, Decourtye-Espiard, Lyvianne, Mitchell, Wilson, Redpath, Kieran, Perkinson, Jacqui, Godwin, Tanis, Black, Michael A., Guilford, Parry
Publicado 2022

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

por Bougen-Zhukov, Nicola, Nouri, Yasmin, Godwin, Tanis, Taylor, Megan, Hakkaart, Christopher, Single, Andrew, Brew, Tom, Permina, Elizabeth, Chen, Augustine, Black, Michael A., Guilford, Parry
Publicado 2019

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

por Godwin, Tanis D., Kelly, S. Thomas, Brew, Tom P., Bougen-Zhukov, Nicola M., Single, Andrew B., Chen, Augustine, Stylianou, Cassie E., Harris, Lawrence D., Currie, Sophie K., Telford, Bryony J., Beetham, Henry G., Evans, Gary B., Black, Michael A., Guilford, Parry J.
Publicado 2018