Current proteomics methods applicable to dissecting the DNA damage response

por Muralidharan, Monita, Krogan, Nevan J, Bouhaddou, Mehdi, Kim, Minkyu
Publicado 2023

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma

por Jones, DeAnalisa C., Scanteianu, Adriana, DiStefano, Matthew, Bouhaddou, Mehdi, Birtwistle, Marc R.
Publicado 2018

Network inference from perturbation time course data

por Sarmah, Deepraj, Smith, Gregory R., Bouhaddou, Mehdi, Stern, Alan D., Erskine, James, Birtwistle, Marc R.
Publicado 2022

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array

por Koch, Rick J., Barrette, Anne Marie, Stern, Alan D., Hu, Bin, Bouhaddou, Mehdi, Azeloglu, Evren U., Iyengar, Ravi, Birtwistle, Marc R.
Publicado 2018

Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

por Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje‐Christine
Publicado 2020

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

por Wang, Ruofan, Simoneau, Camille R., Kulsuptrakul, Jessie, Bouhaddou, Mehdi, Travisano, Katherine, Hayashi, Jennifer M., Carlson-Stevermer, Jared, Oki, Jennifer, Holden, Kevin, Krogan, Nevan J., Ott, Melanie, Puschnik, Andreas S.
Publicado 2020

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens

por Bouhaddou, Mehdi, Barrette, Anne Marie, Stern, Alan D., Koch, Rick J., DiStefano, Matthew S., Riesel, Eric A., Santos, Luis C., Tan, Annie L., Mertz, Alex E., Birtwistle, Marc R.
Publicado 2018

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling

por Erdem, Cemal, Mutsuddy, Arnab, Bensman, Ethan M., Dodd, William B., Saint-Antoine, Michael M., Bouhaddou, Mehdi, Blake, Robert C., Gross, Sean M., Heiser, Laura M., Feltus, F. Alex, Birtwistle, Marc R.
Publicado 2022

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

por Wang, Ruofan, Simoneau, Camille R., Kulsuptrakul, Jessie, Bouhaddou, Mehdi, Travisano, Katherine A., Hayashi, Jennifer M., Carlson-Stevermer, Jared, Zengel, James R., Richards, Christopher M., Fozouni, Parinaz, Oki, Jennifer, Rodriguez, Lauren, Joehnk, Bastian, Walcott, Keith, Holden, Kevin, Sil, Anita, Carette, Jan E., Krogan, Nevan J., Ott, Melanie, Puschnik, Andreas S.
Publicado 2021

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

por Mendiola, Andrew S., Yan, Zhaoqi, Dixit, Karuna, Johnson, Jeffrey R., Bouhaddou, Mehdi, Meyer-Franke, Anke, Shin, Min-Gyoung, Yong, Yu, Agrawal, Ayushi, MacDonald, Eilidh, Muthukumar, Gayathri, Pearce, Clairice, Arun, Nikhita, Cabriga, Belinda, Meza-Acevedo, Rosa, Alzamora, Maria del Pilar S., Zamvil, Scott S., Pico, Alexander R., Ryu, Jae Kyu, Krogan, Nevan J., Akassoglou, Katerina
Publicado 2023

A Comparison of mRNA Sequencing with Random Primed and 3′-Directed Libraries

por Xiong, Yuguang, Soumillon, Magali, Wu, Jie, Hansen, Jens, Hu, Bin, van Hasselt, Johan G. C., Jayaraman, Gomathi, Lim, Ryan, Bouhaddou, Mehdi, Ornelas, Loren, Bochicchio, Jim, Lenaeus, Lindsay, Stocksdale, Jennifer, Shim, Jaehee, Gomez, Emilda, Sareen, Dhruv, Svendsen, Clive, Thompson, Leslie M., Mahajan, Milind, Iyengar, Ravi, Sobie, Eric A., Azeloglu, Evren U., Birtwistle, Marc R.
Publicado 2017

Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

por Chan, Gary KL, Maisel, Samantha, Hwang, Yeonjoo C, Pascual, Bryan C, Wolber, Rebecca RB, Vu, Phuong, Patra, Krushna C, Bouhaddou, Mehdi, Kenerson, Heidi L, Lim, Huat C, Long, Donald, Yeung, Raymond S, Sethupathy, Praveen, Swaney, Danielle L, Krogan, Nevan J, Turnham, Rigney E, Riehle, Kimberly J, Scott, John D, Bardeesy, Nabeel, Gordan, John D
Publicado 2023

Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer

por Bouhaddou, Mehdi, Lee, Rex H., Li, Hua, Bhola, Neil E., O’Keefe, Rachel A., Naser, Mohammad, Zhu, Tian Ran, Nwachuku, Kelechi, Duvvuri, Umamaheswar, Olshen, Adam B., Roy, Ritu, Hechmer, Aaron, Bolen, Jennifer, Keysar, Stephen B., Jimeno, Antonio, Mills, Gordon B., Vandenberg, Scott, Swaney, Danielle L., Johnson, Daniel E., Krogan, Nevan J., Grandis, Jennifer R.
Publicado 2021

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

por Reuschl, Ann-Kathrin, Thorne, Lucy G., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Hiatt, Joseph, Soucheray, Margaret, Turner, Jane, Fabius, Jacqueline M., Nguyen, Gina T., Swaney, Danielle L., Rosales, Romel, White, Kris M., Avilés, Pablo, Kirby, Ilsa T., Melnyk, James E., Shi, Ying, Zhang, Ziyang, Shokat, Kevan M., García-Sastre, Adolfo, Jolly, Clare, Towers, Gregory J., Krogan, Nevan J.
Publicado 2021

A functional map of HIV-host interactions in primary human T cells

por Hiatt, Joseph, Hultquist, Judd F., McGregor, Michael J., Bouhaddou, Mehdi, Leenay, Ryan T., Simons, Lacy M., Young, Janet M., Haas, Paige, Roth, Theodore L., Tobin, Victoria, Wojcechowskyj, Jason A., Woo, Jonathan M., Rathore, Ujjwal, Cavero, Devin A., Shifrut, Eric, Nguyen, Thong T., Haas, Kelsey M., Malik, Harmit S., Doudna, Jennifer A., May, Andrew P., Marson, Alexander, Krogan, Nevan J.
Publicado 2022

Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

por Chong, Stephen Jun Fei, Zhu, Fen, Dashevsky, Olga, Mizuno, Rin, Lai, Jolin X.H., Hackett, Liam, Ryan, Christine E., Collins, Mary C., Iorgulescu, J. Bryan, Guièze, Romain, Penailillo, Johany, Carrasco, Ruben, Hwang, Yeonjoo C., Muñoz, Denise P., Bouhaddou, Mehdi, Lim, Yaw Chyn, Wu, Catherine J., Allan, John N., Furman, Richard R., Goh, Boon Cher, Pervaiz, Shazib, Coppé, Jean-Philippe, Mitsiades, Constantine S., Davids, Matthew S.
Publicado 2023

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

por White, Kris M., Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B., Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M., Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M., Krogan, Nevan J., García-Sastre, Adolfo
Publicado 2021

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

por Escalera, Alba, Gonzalez-Reiche, Ana S., Aslam, Sadaf, Mena, Ignacio, Laporte, Manon, Pearl, Rebecca L., Fossati, Andrea, Rathnasinghe, Raveen, Alshammary, Hala, van de Guchte, Adriana, Farrugia, Keith, Qin, Yiren, Bouhaddou, Mehdi, Kehrer, Thomas, Zuliani-Alvarez, Lorena, Meekins, David A., Balaraman, Velmurugan, McDowell, Chester, Richt, Jürgen A., Bajic, Goran, Sordillo, Emilia Mia, Dejosez, Marion, Zwaka, Thomas P., Krogan, Nevan J., Simon, Viviana, Albrecht, Randy A., van Bakel, Harm, García-Sastre, Adolfo, Aydillo, Teresa
Publicado 2022

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

por Thorne, Lucy G, Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Zuliani-Alvarez, Lorena, Polacco, Ben, Pelin, Adrian, Batra, Jyoti, Whelan, Matthew V.X., Ummadi, Manisha, Rojc, Ajda, Turner, Jane, Obernier, Kirsten, Braberg, Hannes, Soucheray, Margaret, Richards, Alicia, Chen, Kuei-Ho, Harjai, Bhavya, Memon, Danish, Hosmillo, Myra, Hiatt, Joseph, Jahun, Aminu, Goodfellow, Ian G., Fabius, Jacqueline M., Shokat, Kevan, Jura, Natalia, Verba, Klim, Noursadeghi, Mahdad, Beltrao, Pedro, Swaney, Danielle L., Garcia-Sastre, Adolfo, Jolly, Clare, Towers, Greg J., Krogan, Nevan J.
Publicado 2021

Evolution of enhanced innate immune evasion by SARS-CoV-2

por Thorne, Lucy G., Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Zuliani-Alvarez, Lorena, Polacco, Ben, Pelin, Adrian, Batra, Jyoti, Whelan, Matthew V. X., Hosmillo, Myra, Fossati, Andrea, Ragazzini, Roberta, Jungreis, Irwin, Ummadi, Manisha, Rojc, Ajda, Turner, Jane, Bischof, Marie L., Obernier, Kirsten, Braberg, Hannes, Soucheray, Margaret, Richards, Alicia, Chen, Kuei-Ho, Harjai, Bhavya, Memon, Danish, Hiatt, Joseph, Rosales, Romel, McGovern, Briana L., Jahun, Aminu, Fabius, Jacqueline M., White, Kris, Goodfellow, Ian G., Takeuchi, Yasu, Bonfanti, Paola, Shokat, Kevan, Jura, Natalia, Verba, Klim, Noursadeghi, Mahdad, Beltrao, Pedro, Kellis, Manolis, Swaney, Danielle L., García-Sastre, Adolfo, Jolly, Clare, Towers, Greg J., Krogan, Nevan J.
Publicado 2021