Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

por Pierrat, Olivier A., Strisovsky, Kvido, Christova, Yonka, Large, Jonathan, Ansell, Keith, Bouloc, Nathalie, Smiljanic, Ela, Freeman, Matthew
Publicado 2010

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

por Chapman, Timothy M., Bouloc, Nathalie, Buxton, Roger S., Chugh, Jasveen, Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Smerdon, Stephen J., Taylor, Debra L., Whalley, David
Publicado 2012

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

por Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M., Ansell, Keith H., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2014

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

por Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2013

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

por Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Whalley, David, Chapman, Tim, Bouloc, Nathalie, Chugh, Jasveen, Nott, Timothy J., Patel, Dony, Spivey, Vicky L., Kettleborough, Catherine A., Bryans, Justin S., Taylor, Debra L., Smerdon, Stephen J., Buxton, Roger S.
Publicado 2011

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

por Ansell, Keith H., Jones, Hayley M., Whalley, David, Hearn, Alisdair, Taylor, Debra L., Patin, Emmanuel C., Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W., Green, Judith L., Holder, Anthony A.
Publicado 2014

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

por Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.
Publicado 2017