Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli

por Konczal, Jennifer, Bower, Justin, Gray, Christopher H.
Publicado 2019

Implementation of an AI-assisted fragment-generator in an open-source platform

por Bilsland, Alan E., Pugliese, Angelo, Bower, Justin
Publicado 2022

Fragment‐based drug discovery—the importance of high‐quality molecule libraries

por Bon, Marta, Bilsland, Alan, Bower, Justin, McAulay, Kirsten
Publicado 2022

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

por Gray, Christopher H., Konczal, Jennifer, Mezna, Mokdad, Ismail, Shehab, Bower, Justin, Drysdale, Martin
Publicado 2017

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks()()

por Bilsland, Alan E., Pugliese, Angelo, Liu, Yu, Revie, John, Burns, Sharon, McCormick, Carol, Cairney, Claire J., Bower, Justin, Drysdale, Martin, Narita, Masashi, Sadaie, Mahito, Keith, W. Nicol
Publicado 2015

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

por Unbekandt, Mathieu, Croft, Daniel R, Crighton, Diane, Mezna, Mokdad, McArthur, Duncan, McConnell, Patricia, Schüttelkopf, Alexander W, Belshaw, Simone, Pannifer, Andrew, Sime, Mairi, Bower, Justin, Drysdale, Martin, Olson, Michael F
Publicado 2014

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling

por Yelland, Tamas, Garcia, Esther, Parry, Charles, Kowalczyk, Dominika, Wojnowska, Marta, Gohlke, Andrea, Zalar, Matja, Cameron, Kenneth, Goodwin, Gillian, Yu, Qing, Zhu, Peng-Cheng, ElMaghloob, Yasmin, Pugliese, Angelo, Archibald, Lewis, Jamieson, Andrew, Chen, Yong Xiang, McArthur, Duncan, Bower, Justin, Ismail, Shehab
Publicado 2022

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

por Francis, Stuart, Croft, Daniel, Schüttelkopf, Alexander W., Parry, Charles, Pugliese, Angelo, Cameron, Ken, Claydon, Sophie, Drysdale, Martin, Gardner, Claire, Gohlke, Andrea, Goodwin, Gillian, Gray, Christopher H., Konczal, Jennifer, McDonald, Laura, Mezna, Mokdad, Pannifer, Andrew, Paul, Nikki R., Machesky, Laura, McKinnon, Heather, Bower, Justin
Publicado 2019