Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases

por Bowerman, Melissa
Publicado 2020

ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets

por Coque, Emmanuelle, Raoul, Cédric, Bowerman, Mélissa
Publicado 2014

The Relationship between Body Composition, Fatty Acid Metabolism and Diet in Spinal Muscular Atrophy

por Watson, Katherine S., Boukhloufi, Imane, Bowerman, Melissa, Parson, Simon H.
Publicado 2021

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

por Bowerman, Melissa, Murray, Lyndsay M, Boyer, Justin G, Anderson, Carrie L, Kothary, Rashmi
Publicado 2012

Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis

por Bowerman, Melissa, Vincent, Thierry, Scamps, Frédérique, Perrin, Florence E., Camu, William, Raoul, Cédric
Publicado 2013

Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology

por Bowerman, Melissa, Michalski, John-Paul, Beauvais, Ariane, Murray, Lyndsay M., DeRepentigny, Yves, Kothary, Rashmi
Publicado 2014

Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA)

por Šoltić, Darija, Bowerman, Melissa, Stock, Joanne, Shorrock, Hannah K., Gillingwater, Thomas H., Fuller, Heidi R.
Publicado 2018

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides

por Selvakumaran, Jamuna, Ursu, Simona, Bowerman, Melissa, Lu-Nguyen, Ngoc, Wood, Matthew J., Malerba, Alberto, Yáñez-Muñoz, Rafael J.
Publicado 2023

Therapeutic strategies for spinal muscular atrophy: SMN and beyond

por Bowerman, Melissa, Becker, Catherina G., Yáñez-Muñoz, Rafael J., Ning, Ke, Wood, Matthew J. A., Gillingwater, Thomas H., Talbot, Kevin
Publicado 2017

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

por Ahlskog, Nina, Hayler, Daniel, Krueger, Anja, Kubinski, Sabrina, Claus, Peter, Hammond, Suzan M., Wood, Matthew J. A., Yáñez-Muñoz, Rafael J., Bowerman, Melissa
Publicado 2020

Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

por Winkelsas, Audrey M., Grunseich, Christopher, Harmison, George G., Chwalenia, Katarzyna, Rinaldi, Carlo, Hammond, Suzan M., Johnson, Kory, Bowerman, Melissa, Arya, Sukrat, Talbot, Kevin, Wood, Matthew J., Fischbeck, Kenneth H.
Publicado 2021

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/−) spinal muscular atrophy mice

por Brown, Sharon J, Šoltić, Darija, Synowsky, Silvia A, Shirran, Sally L, Chilcott, Ellie, Shorrock, Hannah K, Gillingwater, Thomas H, Yáñez-Muñoz, Rafael J, Schneider, Bernard, Bowerman, Melissa, Fuller, Heidi R
Publicado 2023

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

por Meijboom, Katharina E., Volpato, Viola, Monzón-Sandoval, Jimena, Hoolachan, Joseph M., Hammond, Suzan M., Abendroth, Frank, de Jong, Olivier G., Hazell, Gareth, Ahlskog, Nina, Wood, Matthew J.A., Webber, Caleb, Bowerman, Melissa
Publicado 2021

Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice

por Walter, Lisa M, Koch, Christiane E, Betts, Corinne A, Ahlskog, Nina, Meijboom, Katharina E, van Westering, Tirsa L E, Hazell, Gareth, Bhomra, Amarjit, Claus, Peter, Oster, Henrik, Wood, Matthew J A, Bowerman, Melissa
Publicado 2018

A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN

por Rademacher, Sebastian, Detering, Nora T., Schüning, Tobias, Lindner, Robert, Santonicola, Pamela, Wefel, Inga-Maria, Dehus, Janina, Walter, Lisa M., Brinkmann, Hella, Niewienda, Agathe, Janek, Katharina, Varela, Miguel A., Bowerman, Melissa, Di Schiavi, Elia, Claus, Peter
Publicado 2020

Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

por Meijboom, Katharina E., Sutton, Emma R., McCallion, Eve, McFall, Emily, Anthony, Daniel, Edwards, Benjamin, Kubinski, Sabrina, Tapken, Ines, Bünermann, Ines, Hazell, Gareth, Ahlskog, Nina, Claus, Peter, Davies, Kay E., Kothary, Rashmi, Wood, Matthew J. A., Bowerman, Melissa
Publicado 2022

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

por Walter, Lisa M., Deguise, Marc-Olivier, Meijboom, Katharina E., Betts, Corinne A., Ahlskog, Nina, van Westering, Tirsa L.E., Hazell, Gareth, McFall, Emily, Kordala, Anna, Hammond, Suzan M., Abendroth, Frank, Murray, Lyndsay M., Shorrock, Hannah K., Prosdocimo, Domenick A., Haldar, Saptarsi M., Jain, Mukesh K., Gillingwater, Thomas H., Claus, Peter, Kothary, Rashmi, Wood, Matthew J.A., Bowerman, Melissa
Publicado 2018

Abnormal fatty acid metabolism is a core component of spinal muscular atrophy

por Deguise, Marc‐Olivier, Baranello, Giovanni, Mastella, Chiara, Beauvais, Ariane, Michaud, Jean, Leone, Alessandro, De Amicis, Ramona, Battezzati, Alberto, Dunham, Christopher, Selby, Kathryn, Warman Chardon, Jodi, McMillan, Hugh J., Huang, Yu‐Ting, Courtney, Natalie L., Mole, Alannah J., Kubinski, Sabrina, Claus, Peter, Murray, Lyndsay M., Bowerman, Melissa, Gillingwater, Thomas H., Bertoli, Simona, Parson, Simon H., Kothary, Rashmi
Publicado 2019

Dystrophin involvement in peripheral circadian SRF signalling

por Betts, Corinne A, Jagannath, Aarti, van Westering, Tirsa LE, Bowerman, Melissa, Banerjee, Subhashis, Meng, Jinhong, Falzarano, Maria Sofia, Cravo, Lara, McClorey, Graham, Meijboom, Katharina E, Bhomra, Amarjit, Lim, Wooi Fang, Rinaldi, Carlo, Counsell, John R, Chwalenia, Katarzyna, O’Donovan, Elizabeth, Saleh, Amer F, Gait, Michael J, Morgan, Jennifer E, Ferlini, Alessandra, Foster, Russell G, Wood, Matthew JA
Publicado 2021