Viral evasion and subversion of pattern-recognition receptor signalling

por Bowie, Andrew G., Unterholzner, Leonie
Publicado 2008

PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells

por Massa, Davide, Baran, Marcin, Bengoechea, Jose A., Bowie, Andrew G.
Publicado 2020

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores

por Guy, Coralie, Baran, Marcin, Ribó-Molina, Pau, van den Hoogen, Bernadette G., Bowie, Andrew G.
Publicado 2023

Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

por Musilova, Jana, Mulcahy, Michelle E., Kuijk, Marieke M., McLoughlin, Rachel M., Bowie, Andrew G.
Publicado 2019

Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication

por Singh, Saravjeet, O’Reilly, Sophie, Gewaid, Hossam, Bowie, Andrew G., Gautier, Virginie, Worrall, D. Margaret
Publicado 2022

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

por Cox, Donal J., Field, Robert H., Williams, David G., Baran, Marcin, Bowie, Andrew G., Cunningham, Colm, Dunne, Aisling
Publicado 2015

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

por Leow-Dyke, Sophie, Allen, Charlotte, Denes, Adam, Nilsson, Olov, Maysami, Samaneh, Bowie, Andrew G, Rothwell, Nancy J, Pinteaux, Emmanuel
Publicado 2012

Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

por Gu, Lili, Casserly, David, Brady, Gareth, Carpenter, Susan, Bracken, Adrian P., Fitzgerald, Katherine A., Unterholzner, Leonie, Bowie, Andrew G.
Publicado 2022

Alum Activates the Bovine NLRP3 Inflammasome

por Harte, Ciaran, Gorman, Aoife L., McCluskey, S., Carty, Michael, Bowie, Andrew G., Scott, C. J., Meade, Kieran G., Lavelle, Ed C.
Publicado 2017

SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

por Finnegan, Laura K., Chadderton, Naomi, Kenna, Paul F., Palfi, Arpad, Carty, Michael, Bowie, Andrew G., Millington-Ward, Sophia, Farrar, G. Jane
Publicado 2022

SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

por Gibbons, Luke, Ozaki, Ema, Greene, Chris, Trappe, Anne, Carty, Michael, Coppinger, Judith A., Bowie, Andrew G., Campbell, Matthew, Doyle, Sarah L.
Publicado 2022

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

por Unterholzner, Leonie, Sumner, Rebecca P., Baran, Marcin, Ren, Hongwei, Mansur, Daniel S., Bourke, Nollaig M., Randow, Felix, Smith, Geoffrey L., Bowie, Andrew G.
Publicado 2011

Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

por Stack, Julianne, Haga, Ismar R., Schröder, Martina, Bartlett, Nathan W., Maloney, Geraldine, Reading, Patrick C., Fitzgerald, Katherine A., Smith, Geoffrey L., Bowie, Andrew G.
Publicado 2005

Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

por Mansur, Daniel S., Maluquer de Motes, Carlos, Unterholzner, Leonie, Sumner, Rebecca P., Ferguson, Brian J., Ren, Hongwei, Strnadova, Pavla, Bowie, Andrew G., Smith, Geoffrey L.
Publicado 2013

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

por Dunphy, Gillian, Flannery, Sinéad M., Almine, Jessica F., Connolly, Dympna J., Paulus, Christina, Jønsson, Kasper L., Jakobsen, Martin R., Nevels, Michael M., Bowie, Andrew G., Unterholzner, Leonie
Publicado 2018

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

por Feriotti, Claudia, Sá-Pessoa, Joana, Calderón-González, Ricardo, Gu, Lili, Morris, Brenda, Sugisawa, Ryoichi, Insua, Jose L., Carty, Michael, Dumigan, Amy, Ingram, Rebecca J., Kissenpfening, Adrien, Bowie, Andrew G., Bengoechea, José A.
Publicado 2022

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

por Almine, Jessica F., O'Hare, Craig A. J., Dunphy, Gillian, Haga, Ismar R., Naik, Rangeetha J., Atrih, Abdelmadjid, Connolly, Dympna J., Taylor, Jordan, Kelsall, Ian R., Bowie, Andrew G., Beard, Philippa M., Unterholzner, Leonie
Publicado 2017

Novel Strategies for Targeting Innate Immune Responses to Influenza

por Shirey, Kari Ann, Lai, Wendy, Patel, Mira C., Pletneva, Lioubov M., Pang, Catherine, Kurt-Jones, Evelyn, Lipsky, Michael, Roger, Thierry, Calandra, Thierry, Tracey, Kevin, Al-Abed, Yousef, Bowie, Andrew G., Fasano, Alessio, Dinarello, Charles, Gusovsky, Fabian, Blanco, Jorge C.G., Vogel, Stefanie N.
Publicado 2016

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

por Muñoz-Wolf, Natalia, Ward, Ross W., Hearnden, Claire H., Sharp, Fiona A., Geoghegan, Joan, O’Grady, Katie, McEntee, Craig P., Shanahan, Katharine A., Guy, Coralie, Bowie, Andrew G., Campbell, Matthew, Roces, Carla.B., Anderluzzi, Giulia, Webb, Cameron, Perrie, Yvonne, Creagh, Emma, Lavelle, Ed C.
Publicado 2023

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

por Sisquella, Xavier, Ofir-Birin, Yifat, Pimentel, Matthew A., Cheng, Lesley, Abou Karam, Paula, Sampaio, Natália G., Penington, Jocelyn Sietsma, Connolly, Dympna, Giladi, Tal, Scicluna, Benjamin J., Sharples, Robyn A., Waltmann, Andreea, Avni, Dror, Schwartz, Eli, Schofield, Louis, Porat, Ziv, Hansen, Diana S., Papenfuss, Anthony T., Eriksson, Emily M., Gerlic, Motti, Hill, Andrew F., Bowie, Andrew G., Regev-Rudzki, Neta
Publicado 2017